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This Week in Virology

Author: Vincent Racaniello

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TWiV is a weekly netcast about viruses - the kind that make you sick. Professors Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler and science writer Alan Dove and guests deconstruct viruses, how they cause illness, and dissect the latest research.
336 Episodes
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Jon Yewdell returns to explain studies on detection of antibodies and T cell epitopes in patients who have recovered from COVID-19. Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker Guest: Jon Yewdell Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode T cell targets in COVID-19 patients (Cell) SARS-CoV-2 seroconversion in humans (Nat Med) Convergent antibody responses to SARS-CoV-2 infection (bioRxiv) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv
Raul Rabadan joins TWiV to explain the use of computational biology to demonstrate how recombination and mutation led to emergence of SARS-CoV-2. Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker Guest: Raul Rabadan Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Rabadan Laboratory Understanding Coronavirus (Amazon) Topological Data Analysis for Genomics and Evolution (Amazon) Recombination and mutation shaped SARS-CoV-2 (bioRxiv) Bat CoV with cleavage site insertion (Curr Biol) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv
From the Nipah Virus International Conference in Singapore, Vincent speaks with meeting participants about the history of the first Nipah virus outbreak, lessons learned from Hendra virus, surveillance of bats for viruses, and the development of a vaccine. Hosts: Vincent Racaniello Guests: John Mackenzie, Jon Epstein, Eun-Chung Park, and Linfa Wang Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv
TWiV 617: Coronavirus Times

TWiV 617: Coronavirus Times

2020-05-2402:34:453

Daniel Griffin provides a clinical update on COVID-19, then we review TETRIS by Paterson NJ, modeling the effects of intervention in the US on cases and deaths, mixing PCR and serology data, and much more, including listener email. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Playing tennis safely (USTA) Scientists denounce end to CoV grant (NY Times) ASMBMB denounces end to CoV grant (pdf) For TETRIS, turn to Paterson NJ (NY Times) NJ Dept of Health (image credit) Differential effects of intervention timing (medRxiv and NY Times) Texas to stop combining test results (Statesman) How could CDC make that mistake? (Atlantic) The Pandemic and Information Network (Columbia Journ Rev) Helmet and tent (Science) New song, old melody (Cell Host Microbe) Letters read on TWiV 617 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv
Vincent, Kathy and Rich discuss COVID-19 research paper overload, Moderna's mRNA vaccine Phase I results, increase of ACE2 RNA by cigarette smoke, and answer listener questions. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Drowning in COVID-19 papers (Science) CORD-19 2019 NCRC AI powered literature review SciSight Graphical guide to CoV vaccines (Nature) Moderna Phase I results Liposomes and lipid nanoparticles (Exelead) Cigarette smoke increases ACE2 (Dev Cell) Letters read on TWiV 616 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv
Vincent speaks with Peter Daszak, President of EcoHealth Alliance, a global nonprofit organization dedicated to protecting wildlife and public health from the emergence of disease. Hosts: Vincent Racaniello Guests: Peter Daszak Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Intro music is by Ronald Jenkees. 20% off The Invisible ABCs for TWiV listeners! Use promo code: ABC20 at checkout. Send your virology questions and comments to twiv@microbe.tv
Daniel Griffin provides a clinical update on COVID-19, then we review results showing requirement for the furin site in the SARS-CoV-2 spike for replication, US state vaccine exemptions, concerns with a rapid diagnostic test, and answers to listener questions. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Triple therapy for COVID-19 (Lancet) Virology podcast goes viral (Thalia Gigerenzer) Paul Stays Home (pdf) Multibasic cleavage site essential for SARS-CoV-2 infection (Mol Cell) Mumbai engulfed by CoV (NY Times) All must be vaccinated (Stat) FDA concerns with Abbott test (FDA) How US lost 6 weeks (BBC) Image credit Letters read on TWiV 614 20% off The Invisible ABCs for TWiV listeners! Use promo code: ABC20 at checkout. Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv
Vincent, Kathy and Rich explain the Jenner Institute's SARS-CoV-2 vaccine, the NIH decision to stop the Remdesivir study, and answer listener questions. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode COVID-19 brings out dark side of science (Mother Jones, Wired) Jenner Institute COVID-19 vaccine (BioSpace) Recombineering (Nucleic Acids Res) Vaccines lecture (YouTube) ChAdOx1 MERS vaccines protects NHP (Lancet Inf Dis) Chimpanzee adenovirus vector (PLoS One) Ad-MERS vaccine protects monkeys (NIH) Rapid COVID-19 vaccine development (Science) Strategic approach to COVID-19 vaccines (Science) NIH decision to stop remdesivir study (Stat) 80,000 flu deaths this winter (Stat) Science and singing (YouTube) COVID-19 at choir practice (Emerg Inf Dis) 20% off The Invisible ABCs for TWiV listeners! Use promo code: ABC20 at checkout. Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv
From the Nipah Virus International Conference in Singapore, Vincent speaks with Richard Hatchett, CEO of CEPI, about its mission to stimulate and accelerate the development of vaccines against emerging infectious diseases. Hosts: Vincent Racaniello Guests: Richard Hatchett and Linfa Wang Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv
TWiV 611: Corona and crowns

TWiV 611: Corona and crowns

2020-05-1002:26:291

Daniel Griffin provides a weekly clinical update on COVID-19, then Michael Schmidt discusses how dentistry can be safely practiced during a pandemic, followed by answers to listener questions. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guests: Daniel Griffin and Michael Schmidt Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode OSHA guidance for dentistry COVID0-19 challenges for dentistry (J Dent Res) COVID-19 and dentistry (Int J Env Res Pub Health) Mouthrinses for dentistry (J Clin Med) Disingenuous plandemic documentary (Big Think) Letters read on TWiV 611 Image credit Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv
TWiV 610: Coronavirus FAQ

TWiV 610: Coronavirus FAQ

2020-05-0701:39:161

The TWiV team summarizes serology-based tests for SARS-CoV-2, lack of effect of ACE inhibitors or ARBs on COVID-19 severity, and answers listener questions. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode FDA revises statement on antibody tests (FDA) Serology-based tests for SARS-CoV-2 (Center for Health Security) ACE inhibitors, ARBs not linked to COVID-19 severity (Mehra study, Mancia study, Reynolds study) Global COVID-19 CFR (CEBM) Debunking transmission mutation: TWiEVO 55 Letters read on TWiV 610 Image credit Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv
Susan Weiss recalls some of her 40 years of research on coronaviruses, including mouse hepatitis virus, MERS-CoV, and now SARS-CoV-2. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Susan Weiss Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Coronaviruses by Susan Weiss (YouTube) Forty years with coronaviruses (JEM) No credible evidence that SARS-CoV-2 came from a lab (Emerg Micr Infect) CoV and antagonism of RNAse L (mBio) Exoribonuclease needed for MHV innate antagonism (J Virol) RNAse L and ADAR (eLife) Emerging viruses respiratory award (Amer Lung Assoc) Image credit Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv
Daniel Griffin updates the clinical situation with COVID-19 patients, followed by analysis of the remedesivir clinical trial results, and answers listener questions. Hosts: Vincent Racaniello and Rich Condit Guest: Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Pulmonary embolism in COVID-19 (Emerg Inf Dis) Patch Study Remdesivir in adults with severe COVID-19 (Lancet) ACTT remdesivir trial (NIAID) Commentary on remdesivir trials (Lancet) FDA expected to issue remdesivir EUA (Contaigon Live) Recovered COVID-19 patients wrong (Korea Herald) Letters read on TWiV 608 Image credit Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv
Jeff Shaman returns to TWiV to explain why more SARS-CoV-2 testing and contact tracing is needed to stop the pandemic, and provide insights on immunity and reinfection from seasonal CoVs, the problems with antibody tests, and what to expect in the coming months. Hosts: Vincent Racaniello and Rich Condit Guest: Jeff Shaman Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode COVID-19 findings and simulations (Shaman Lab) Reconciling diverse estimates of infection rates (pdf) Undocumented SARS-CoV-2 infections (Science) Simulations of SARS-CoV-2 spread (pdf) Repeated infections with diverse CoV (pdf) Letters read on TWiV 606 Image credit Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv
Daniel Griffin provides his weekly update on the COVID-19 clinical situation, followed by our discussion of tests of an inactivated vaccine, results of serological surveys, an inhibitor of the cell protease needed for virus entry, and answers to listener questions. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Guest: Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Inactivated SARS-CoV-2 vaccine protects monkeys (bioRxiv) Saliva is more sensitve than nasopharyngeal swab (medRxiv) NY serological survey results (NY Times) FDA caveats on serological tests (FDA) Federal guidelines on when to open When to open: Roadmap, blog, video explainer Blocking TMPRSS2 blocks SARS-CoV-2 infection (Cell) Lawmakers want human challenge studies (Science) Letters read on TWiV 606 Image credit Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv
Ralph Baric, Mark Heise and Nat Moorman discuss their non-profit initiative READDI, Rapidly Emerging Antiviral Drug Discovery Initiative, to start making drugs now for the next pandemic virus. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Guests: Ralph Baric, Mark Heise, and Nat Moorman Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode READDI.org CEPI DNDi Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv
Kostya Chumakov discusses the hypothesis that oral poliovirus vaccine can provide non-specific protection against many other viruses, and might prevent infection with SARS-CoV-2. Host: Vincent Racaniello Guest: Kostya Chumakov Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Nonpathogenic enteroviruses to prevent human disease (pdf) OPV for COVID-19 (pdf) Enteroviruses to prevent human infections (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv
Daniel Griffin provides his weekly update on the COVID-19 clinical situation, followed by results of seroprevalence studies, analysis of CpG dinucleotide frequencies in the SARS-CoV-2 genome, and answers to listener questions. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode CpG frequency in SARS-CoV-2 genome (Mol Biol Evol) SARS-CoV-2 screening before delivery (NEJM) SARS-CoV-2 seroprevalence in Santa Clara (medRxiv) SARS-CoV-2 seroprevalence in homeless shelter (NEPR) Letters read on TWiV 603 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv
Stanley Perlman joins TWiV to discuss immune responses to coronaviruses, including seasonal CoV, MERS, SARS, and SARS-CoV-2, including prospects for a vaccine. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Stanley Perlman Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Perlman Laboratory An Iowa Caucus of Viruses (TWiV 538) Anti-SARS-CoV spike IgG and acute lung injury (JCI Insight) T cell responses to respiratory CoV (Immunol Res) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv
Coronavirus expert Christian Drosten joins Vincent to provide a view from Germany on COVID-19 and SARS-CoV-2. Host: Vincent Racaniello Guest: Christian Drosten Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Das Coronavirus podcast Identification of SARS-CoV in Germany (NEJM) 29 nt deletion in genome of SARS-CoV (Sci Rep) 382 nt deletion in genome of SARS-CoV-2 (bioRxiv) Virological assessment of COVID-19 patients (Nature) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv
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Comments (2)

Melissa Telfer

Love your show! I've been listening for almost a decade and as I travel through university in my final year I can actually understand what you're talking about lol. Is it possible to have some of the papers referred to in the talk linked in the show notes? Keep up the super work!

Apr 10th
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Cheryl McDonald Wensing

TWIV, TWIEVO, TWIP, TWIM, are all, by far the best podcasts I've ever found. The perfect blend of knowledge and personable comradery. I wish there was a history pod cast as expertly crafted!

Nov 27th
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