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JAMA Clinical Reviews

Author: JAMA Network

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Author interviews that explore the latest clinical reviews.
238 Episodes
Irritable bowel syndrome (IBS) is a clinical syndrome of vague abdominal pain and cramping associated with diarrhea or constipation. IBS is a diagnosis of exclusion, and a variety of treatments can improve its symptoms. Michael Camilleri, MD, professor of medicine at the Mayo Clinic, discusses recent advances in the diagnosis and management of IBS. Related Content: Diagnosis and Treatment of Irritable Bowel Syndrome
The Pfizer-BioNTech and Moderna COVID-19 mRNA vaccines are the first of many being tested for widespread use. Buddy Creech, MD, MPH, director of the Vanderbilt Vaccine Research Program, reviews these and other vaccines likely to become available, including products that use inactivated, protein subunit, and viral vector immunization strategies. Related Content: SARS-CoV-2 Vaccines
Advance Directives

Advance Directives


Advance directives (ADs) allow patients to express their medical treatment preferences. Patients with ADs are more likely to receive medical care concordant with their wishes and are less likely to die in the hospital than patients without them, but use remains low in the US. Maria Silvera, MD, a palliative care physician and associate professor of medicine at the University of Michigan, and Catherine Auriemma, MD, a fellow in pulmonary/critical care medicine at the University of Pennsylvania, discuss the importance of ADs and strategies to increase their uptake. Related Article: Completion of Advance Directives and Documented Care Preferences During the Coronavirus Disease 2019 (COVID-19) Pandemic
The CDC coordinated a massive effort to immunize nearly all nursing home and long-term care facility residents in the US against COVID-19 infection in the month after vaccine approval. Ruth Link-Gelles, PhD, MPH, CDC staff epidemiologist and Lieutenant Commander of the US Public Health Service Commissioned Corps, describes how. Related Article(s): First-Dose COVID-19 Vaccination Coverage Among Skilled Nursing Facility Residents and Staff Nursing Homes’ Next Test—Vaccinating Workers Against COVID-19
Highly effective B-cell therapies like rituximab and ofatumumab have changed the outlook for patients with multiple sclerosis (MS). Alexander Rae-Grant, MD, emeritus professor of neurology at the Cleveland Clinic Lerner College of Medicine, discusses recent advances in the diagnosis and treatment of MS. Related Article(s): Diagnosis and Treatment of Multiple Sclerosis Progress in Multiple Sclerosis Research
Many physicians are skeptical of structural racism, the idea that economic, educational, and other social systems preferentially disadvantage Black Americans and other communities of color. Mitchell Katz, MD, president and chief executive officer of NYC Health + Hospitals, the largest US public health care system, is an expert in health care delivery to disadvantaged populations. He explains how structural racism worsens health outcomes and what health systems can do to address it. Related: Racial and Ethnic Disparities in COVID-19 The Winter COVID-19 Surge in New York and Los Angeles Diversifying Medical Education Surgeon Creates Barrier-Free COVID-19 Testing Service for Philadelphia's Black Residents Taking a Closer Look at COVID-19, Health Inequities, and Racism Recalibrating the Use of Race in Medical Research Responding to COVID-19 With a Structurally Competent Health Care System
Natural experiments comparing coronavirus spread on ships and in hair salons with vs without face masks point to the importance of wearing masks for curbing SARS-CoV-2 spread. John T. Brooks, MD, chief medical officer of the CDC’s COVID-19 response team, reviews recently published epidemiologic data that reinforce the role of mask use for pandemic control. Related Article: Effectiveness of Mask Wearing to Control Community Spread of SARS-CoV-2
Philip Cohen, MD, associate clinical professor of internal medicine at UCLA, a primary care internist who also specializes in sports medicine, discusses the primary care management of osteoarthritis. Related Articles: Drugs for Osteoarthritis Diagnosis and Treatment of Hip and Knee Osteoarthritis
Immune checkpoint inhibitors have been a major breakthrough in cancer treatment but can have many serious adverse effects. Pankti Reid, MD, MPH, assistant professor of medicine in rheumatology at the University of Chicago, discusses the pathogenesis, diagnosis, and treatment of toxicities from immune checkpoint inhibitors as outlined by the 2019 NCCN guidelines. Related Article: Management of Immunotherapy-Related Toxicities in Patients Treated With Immune Checkpoint Inhibitor Therapy
Howard Reber, MD, emeritus professor of surgery at UCLA, discusses how to treat acute pancreatitis. Related Article(s): Acute Pancreatitis
Howard Reber, MD, emeritus professor of surgery at UCLA, discusses how to diagnose acute pancreatitis. Related Article(s): Acute Pancreatitis
Ethnic and racial minorities have been particularly hard hit with COVID-19 in some communities. Mitchell Katz, MD, president and chief executive officer of New York City Health + Hospitals, and former Los Angeles County health agency director, discusses this problem and what has been learned from COVID-19 that can help resolve the general problem of health care disparities. Related Article: Racial and Ethnic Health Disparities Related to COVID-19
Tobacco use is the leading cause of preventable disease and death in the world, but most attempts to quit are unsuccessful. Atul Jain, MD, assistant professor of medicine at Mayo College of Medicine, discusses new guidelines from the American Thoracic Society on pharmacologic management of tobacco cessation, including target population and deciding when to initiate. Related Article(s): Initiating Pharmacologic Treatment in Tobacco-Dependent Adults
Mitchell Katz, MD, president and chief executive officer of New York City Health + Hospitals, and former Los Angeles County health agency director, discusses causes, similarities, and differences between the spike of COVID-19 cases, hospitalizations, and deaths in the 2 cities. Related Article: Modernize Medical Licensing, and Credentialing, Too—Lessons From the COVID-19 Pandemic
Glaucoma is the most common cause of irreversible blindness in the world. Joshua Stein, MD, MS, associate professor of ophthalmology at the University of Michigan, reviews the diagnosis and treatment of glaucoma. Related Article: Glaucoma in Adults—Screening, Diagnosis, and Management
A new trial reports that a third of emergency department patients presenting with appendicitis admitted for oral antibiotic treatment had outcomes no different from those admitted for intravenous antibiotic treatment. Paulina Salminen, MD, PhD, professor of surgery at the University of Turku in Finland, discusses the findings. Related Article(s): Effect of Oral Moxifloxacin vs Intravenous Ertapenem Plus Oral Levofloxacin for Treatment of Uncomplicated Acute Appendicitis
Gregory Armstrong, MD, director of the Advanced Molecular Detection Program for the CDC, explains what is currently known about the new mutations of SARS-CoV-2. Related Article(s): Genetic Variants of SARS-CoV-2—What Do They Mean? Next-Generation Sequencing of Infectious Pathogens Next Generation Sequencing of Infectious Pathogens in Public Health and Clinical Practice Understanding SARS-CoV-2 Genetic Variants
Next-generation sequencing is a catchall term for new, high-throughput technologies that allow rapid sequencing of a full genome. It can be used to sequence a patient’s DNA in diagnosing a genetic disorder or characterizing a cancer, but it can also be used to sequence the genome of a pathogenic bacteria, virus, fungi, or parasites. In this JAMA clinical review podcast, we talk with authors Marta Gwinn, MD, MPH, and Gregory L. Armstrong, MD, from the CDC, about how next-generation sequencing of infectious pathogens is being implemented in clinical practice and in public health surveillance for infectious disease. Related Article(s): Next-Generation Sequencing of Infectious Pathogens Podcast originally published 2/14/19.
Tom Shimabukuro, MD, MPH, MBA, and Sara Mbaeyi, MD, MPH, from the CDC discuss rare allergic complications in patients who received the first dose of the Pfizer-BioNTech vaccine between December 14-23, 2020.
Patent foramen ovale (PFO) is an often overlooked cause of acute ischemic stroke. JAMA Associate Editor Jeffrey Saver, MD, professor of neurology at UCLA, discusses new recommendations from a 2020 AAN Practice Advisory about use of mechanical PFO closure and anticoagulant vs antiplatelet therapy to prevent subsequent strokes in patients with a PFO and an initial event. Related Article: Management of Patients With a Patent Foramen Ovale With History of Stroke or TIA
Comments (16)

tim jennings

I'm unsure why this podcast episode was published. The host spends the entirety of the episode fighting over the word racism because he thinks racism is illegal and doesn't exist anymore. That's very clearly not the case (we just had Trump as a president, BLM marches, and insane COVID-19 disparities) so maybe he's not the right guy to be hosting something related to structural racism? The guest was okay but because the host was so caught up on the racism word, they got nothing accomplished over 15 minutes and made a fool of themselves in the name of JAMA.

Mar 4th

Amirhossein Azari Jafari

that was such a wonderful story. I was on my cancer article while I was listening to this episode and honestly I shocked and it got me to think carefully. Dr. Stern, deep down in my heart, I wish u the best, Do not lose your hope and always be strong.

Aug 23rd

Lucy K

I guess this podcast got it totally wrong. Tunnel vision.

Apr 10th

Prasad Chalasani

Shockingly bad advice — “asymptomatic people don’t need to wear masks in a grocery store”. It’s been established that people shed virus for up to as much as a week before showing symptoms, if the develop them at all. This advice is doing a huge disservice, I urge you to fix this

Apr 6th
Reply (2)

zahra aghajanzadeh


Mar 21st

Jon Elliott

such crap. no mention of the well-known and understood cause and cure of CAD - DIET AND LIFESTYLE. No surprise that OMT has limited and minimal efficacy when the engine of CAD us left running.

Mar 8th

Nuage Laboratoire


Mar 1st

Yasmine C

Unprofessional behavior leads to complications?! who woulda thunk it?

Feb 28th

Christal Cooper

didn't ask for this movies

Feb 28th

Matt Bowen

God Bless the American Soldier

Nov 28th
Reply (1)

Nathan Birch

9 d

Jul 25th
Reply (1)

Rodrigo Py

Amazing, episode!

May 21st
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