Week 1 of the 2025 NFL season has already set the stage for a thrilling year in fantasy football. Top players like Josh Allen, Derrick Henry, Christian McCaffrey, and breakout star Puka Nacua have earned valuable points, positioning themselves as early favorites this season. As we move into Week 2, fantasy football managers are keen to optimize their lineups with the best selections across all positions.

Quarterbacks continue to dominate conversations as Josh Allen's stellar performance puts him at the forefront of discussions, potentially leading fantasy managers to retain him high on their lists. Other reliable quarterbacks are also showcasing their capabilities, offering depth in this vital position.

For running backs, Derrick Henry and Christian McCaffrey have shown their worth, reaffirming their positions as top-tier picks. Their consistent performance in Week 1 provides a solid foundation for managers seeking reliable options. As the season progresses, these elite running backs will likely remain integral to any championship-contending fantasy team.

Wide receivers are equally essential, with new talents like Puka Nacua making significant waves. His exceptional debut has fantasy players eagerly watching his potential to become a prominent figure, adding valuable points to rosters. As usual, proven wide receivers remain indispensable, combining experience with the potential for explosive plays.

In terms of defense and special teams (DST), Eric Samulski from NBC Sports provides a comprehensive breakdown of Week 2 rankings. With strategic insights into defensive matchups, fantasy managers can identify potential streamers to improve their standings. As defenses can significantly impact weekly performance, selecting the right DST units is crucial for an edge over the competition.

Furthermore, PFF's Nathan Jahnke has provided rest-of-season fantasy football rankings, offering a holistic view post-Week 1. These rankings are crucial for managers seeking long-term strategies beyond immediate matchups, ensuring sustained success throughout the season.

As Week 2 approaches, fantasy football enthusiasts have the opportunity to refine their strategies, building on early performances and adjusting their rosters based on the latest insights. With each passing week, the rankings evolve, keeping players engaged and challenged in the ever-competitive world of fantasy football.