DiscoverThe Curbsiders Internal Medicine Podcast#214 COVID Cakes 3: Llamas, Remdesivir, Strokes, Predicting the Future, and More!
#214 COVID Cakes 3: Llamas, Remdesivir, Strokes, Predicting the Future, and More!

#214 COVID Cakes 3: Llamas, Remdesivir, Strokes, Predicting the Future, and More!

Update: 2020-05-18
Share

Description

Elevate your critical appraisal skills as we review the first RCT of remdesivir and share the latest and greatest COVID-19 stories including: Llama antibodies, Stroke statistics, Future Waves, Exit Strategies and Awake Proning. We’re joined by everyone’s favorite Curbsider/internist/epidemiologist, Rahul Ganatra MD MPH (@rbganatra). Rahul provides critical appraisal of the newest randomized control trial (RCT) on remdesivir from the Lancet, and gives us a lesson on why statistical power is so important to consider. We also share updates on strokes, awake proning, pandemic predictions, and we reveal another reason to love llamas (besides those luscious lashes). Llama mia, here we go again!

 

Show Notes | Subscribe | Spotify | Swag! | Top Picks | Mailing List | thecurbsiders@gmail.com | CME!

 

 

Credits

  • Written and Produced by: Sarah P. Roberts MPH, Rahul Ganatra MD, MPH, Emi Okamoto MD, Paul Williams MD and Matthew Watto MD
  • Cover Art: Beth Garbitelli
  • Hosts: Sarah P. Roberts MPH, Matthew Watto MD, Paul Williams MD, Rahul Ganatra MD MPH, Emi Okamoto MD   
  • Editor: Matthew Watto MD (written materials); Clair Morgan of nodderly.com

 

 

Sponsors

We are excited to announce that the Curbsiders are now partnering with VCU Health Continuing Education to offer continuing education credits for physicians and other healthcare professionals. Check out curbsiders.vcuhealth.org for more information.

 

Time Stamps

  • 00:00 Intro
  • 02:10 Fun animal facts: Llama antibodies
  • 09:10 Remdesivir RCT by Wang et al
  • 12:40 Power and Sample Size
  • 16:32 Baseline Characteristics, Results and Author’s conclusions
  • 19:15 Rahul’s conclusions: How chance and bias effected the results
  • 24:00 Right censoring; Viral load and timing of antivirals
  • 30:30 Final thoughts on Remdesivir RCT by Wang et al; Looking ahead to the NIAID (ACTT) trial
  • 33:53 Are patients really having less strokes and heart attacks?
  • 38:20 Awake proning
  • 43:30 Paul teaches us not to use the term “happy hypoxemic”
  • 45:00 CIDRAP viewpoint on future waves and exit strategies
  • 50:22 Outro

 

Goal

Listeners will hone their skills in critical appraisal as they update themselves on all things COVID-19

 

Learning objectives

After listening to this episode listeners will...

  1. Critically appraise recent research on remdesivir as a treatment for COVID-19
  2. Recognize the consequences of COVID-19 on strokes
  3. Discuss the potential benefits of proning for COVID-19 patients
  4. Describe different scenarios likely for the pandemic’s future

 

 

Disclosures

The Curbsiders report no relevant financial disclosures. 

 

 

Citation

Ganatra R, Okamoto E, Williams P, Roberts SP, Watto MF. “#214 COVID Cakes 3: Llamas, Remdesivir, Strokes, Predicting the Future, and More!”. The Curbsiders Internal Medicine Podcast. https://thecurbsiders.com/episode-list May 18, 2020.

Comments 
Download from Google Play
Download from App Store
00:00
00:00
x

0.5x

0.8x

1.0x

1.25x

1.5x

2.0x

3.0x

Sleep Timer

Off

End of Episode

5 Minutes

10 Minutes

15 Minutes

30 Minutes

45 Minutes

60 Minutes

120 Minutes

#214 COVID Cakes 3: Llamas, Remdesivir, Strokes, Predicting the Future, and More!

#214 COVID Cakes 3: Llamas, Remdesivir, Strokes, Predicting the Future, and More!