Glyburide also goes by the brand names of Diabeta, Glynase, and Micronase. It is most commonly used in the treatment of patients with type 2 diabetes. The dosing range varies and is based on the patients blood glucose and the level of control needed. The treatment range is between 1.25-20 mg PO divided 1-2 times daily. Glyburide is given with meals. The mechanism of action lowers blood glucose through the stimulation of pancreatic beta cells. It is very important to note that the conventional and micronized tablets are not interchangeable. The comparison is approximately 1.25 mg to 0.75 mg. Common side effects are weight gain, epigastric discomfort, and blurred vision. The more serious side effects are a disulfiram-like reaction, hypoglycemia, and agranulocytosis.



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