ASNet Primer on Psychopharmacology (part-4)
Update: 2012-10-06
Description
Repeated administration of addictive drugs can result in changes in brain physiology mediating the drug's effects. Tolerance, dependence, and withdrawal reactions are three important distinguishing features often produced by chronic drug administration. This presentation describes these basic neuroadaptive effects and discusses how they are interrelated. Specific examples of physiological dependence and withdrawal reactions from opioids and psychomotor stimulants are discussed. The brief overview of neuroadaptive effects produced by addictive drugs concludes by introducing the concept of sensitization whereby cocaine's effects get stronger (not weaker) across repeated tests with the same drug dosage.
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