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Time Stamps:

00:00:08 - Background and Definitions

00:01:39 - Pathophysiology

00:03:22 - Admission Checklist

00:04:25 - HPI Intake

00:05:51 - Physical Exam

00:06:06 - Differential Diagnosis

00:06:38 - Plan - Workup and Treatment

00:08:54 - If You Remember Nothing Else

00:10:14 - Pearls - Etiology

00:11:00 - Pearls - Presentation and Diagnosis

00:13:07 - Pearls - Treatment

00:15:20 - Literature and Trials

00:15:56 - Wrap Up

Show Notes:

Gout Review (NEJM, 2022)STOP Gout Trial (NEJM, 2022) - allopurinol non-inferior to febuxostat for preventing flares and for reaching target urate concentrations at 48 weeks

CARES Trial (NEJM, 2018) suggested an increased risk of mortality in febuxostat from cardiac events, but a follow-up FAST Trial (Lancet, 2020) showed no difference compared to allopurinol - FDA still has a black box warning

Calcium Pyrophosphate Deposition Disease (CPPD) Review (NEJM, 2016)