Alexander Disease Research Update – Episode #27: Genotype-phenotype association for 14 GFAP variants
Description
Albee Messing, Mel Feany, and Natasha Snider discuss the following recent publication:
Genotype-phenotype association for 14 GFAP variants in Alexander disease.
Neurology: Genetics. 11, e200270 (2025) [full text]
Send your questions and feedback to: amessing@wisc.edu
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1. Berman RF, Matson MR, Bachman AM, Lin N-H, Coyne S, Frelka A, et al. GFAP mutation and astrocyte dysfunction lead to a neurodegenerative profile with impaired synaptic plasticity and cognitive deficits in a rat model of Alexander disease. eNeuro:(in press) (2025)
PMID: 40064497
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J Vis Exp, 18, 55655 (2017)
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Cells, 12, 978 (2023)
A defined roadmap of radial glia and astrocyte differentiation from human pluripotent stem cells
Stem Cell Reports, 18, 1701-1720 (2023)
United States
