Dans cette 69e baladodiffusion, les Drs Luc Lanthier et Alexandre Mutchmore discutent de remplacement valvulaire aortique percutané chez les sujets avec sténose aortique sévère asymptomatique, en plus de réviser la littérature médicale de janvier et février 2025.

Quiz clinique (2 min 25), présentation principale (2 min 50), critique (31 min 59), retour sur le cas clinique (45 min 38), autres articles (46 min 23), réponse au quiz clinique (49 min 40)

Référence principale :

Genereux P, Schwartz A, Oldemeyer JB, Pibarot P, Cohen DJ, Blanke P, et al. Transcatheter Aortic-Valve Replacement for Asymptomatic Severe Aortic Stenosis. N Engl J Med. 2025;392(3):217-27. PubMed PMID: 39466903.

Articles associés : 

Rubino F, Cummings DE, Eckel RH, Cohen RV, Wilding JPH, Brown WA, et al. Definition and diagnostic criteria of clinical obesity. Lancet Diabetes Endocrinol. 2025;13(3):221-62. PubMed PMID: 39824205.

Blankenberg S. Asymptomatic Severe Aortic-Valve Stenosis – To Wait or Not to Wait. N Engl J Med. 2025;392(3):278-9. PubMed PMID: 39813648.

Kang DH, Park SJ, Lee SA, Lee S, Kim DH, Kim HK, et al. Early Surgery or Conservative Care for Asymptomatic Aortic Stenosis. N Engl J Med. 2020;382(2):111-9. PubMed PMID: 31733181.

Banovic M, Putnik S, Penicka M, Doros G, Deja MA, Kockova R, et al. Aortic Valve Replacement Versus Conservative Treatment in Asymptomatic Severe Aortic Stenosis: The AVATAR Trial. Circulation. 2022;145(9):648-58. PubMed PMID: 34779220.

Genereux P, Banovic M, Kang DH, Giustino G, Prendergast BD, Lindman BR, et al. Aortic Valve Replacement vs Clinical Surveillance in Asymptomatic Severe Aortic Stenosis: A Systematic Review and Meta-Analysis. J Am Coll Cardiol. 2025;85(9):912-22. PubMed PMID: 39641732.

Loganath K, Craig NJ, Everett RJ, Bing R, Tsampasian V, Molek P, et al. Early Intervention in Patients With Asymptomatic Severe Aortic Stenosis and Myocardial Fibrosis: The EVOLVED Randomized Clinical Trial. JAMA. 2025;333(3):213-21. PubMed PMID: 39466640.

Vahanian A, Beyersdorf F, Praz F, Milojevic M, Baldus S, Bauersachs J, et al. 2021 ESC/EACTS Guidelines for the management of valvular heart disease. Eur Heart J. 2022;43(7):561-632. PubMed PMID: 34453165.

Otto CM, Nishimura RA, Bonow RO, Carabello BA, Erwin JP, 3rd, et al. 2020 ACC/AHA Guideline for the Management of Patients With Valvular Heart Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol. 2021;77(4):450-500. PubMed PMID: 33342587.

Autres articles d’intérêt récent : 

Packer M, Zile MR, Kramer CM, Baum SJ, Litwin SE, Menon V, et al. Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity. N Engl J Med. 2025;392(5):427-37. PubMed PMID: 39555826.

Feldman WB, Suissa S, Kesselheim AS, Avorn J, Russo M, Schneeweiss S, et al. Comparative effectiveness and safety of single inhaler triple therapies for chronic obstructive pulmonary disease: new user cohort study. BMJ. 2024;387:e080409. PubMed PMID: 39797646.

Piccini JP, Patel MR, Steffel J, Ferdinand K, Van Gelder IC, Russo AM, et al. Asundexian versus Apixaban in Patients with Atrial Fibrillation. N Engl J Med. 2025;392(1):23-32. PubMed PMID: 39225267.

Ruff CT, Patel SM, Giugliano RP, Morrow DA, Hug B, Kuder JF, et al. Abelacimab versus Rivaroxaban in Patients with Atrial Fibrillation. N Engl J Med. 2025;392(4):361-71. PubMed PMID: 39842011.

Ayus JC, Moritz ML, Fuentes NA, Mejia JR, Alfonso JM, Shin S, et al. Correction Rates and Clinical Outcomes in Hospitalized Adults With Severe Hyponatremia: A Systematic Review and Meta-Analysis. JAMA Intern Med. 2025;185(1):38-51. PubMed PMID: 39556338.

Jolly SS, d’Entremont MA, Lee SF, Mian R, Tyrwhitt J, Kedev S, et al. Colchicine in Acute Myocardial Infarction. N Engl J Med. 2025;392(7):633-42. PubMed PMID: 39555823.

Sapp JL, Tang ASL, Parkash R, Stevenson WG, Healey JS, Gula LJ, et al. Catheter Ablation or Antiarrhythmic Drugs for Ventricular Tachycardia. N Engl J Med. 2025;392(8):737-47. PubMed PMID: 39555820.

Group E-KC, Herrington WG, Staplin N, Agrawal N, Wanner C, Green JB, et al. Long-Term Effects of Empagliflozin in Patients with Chronic Kidney Disease. N Engl J Med. 2025;392(8):777-87. PubMed PMID: 39453837.

Fiorella D, Monteith SJ, Hanel R, Atchie B, Boo S, McTaggart RA, et al. Embolization of the Middle Meningeal Artery for Chronic Subdural Hematoma. N Engl J Med. 2025;392(9):855-64. PubMed PMID: 39565980.

Guides de pratique : 

American Diabetes Association Professional Practice C. Summary of Revisions: Standards of Care in Diabetes-2025. Diabetes Care. 2025;48(1 Suppl 1):S6-S13. PubMed PMID: 39651984.

Saukkonen JJ, Duarte R, Munsiff SS, Winston CA, Mammen MJ, Abubakar I, et al. Updates on the Treatment of Drug-Susceptible and Drug-Resistant Tuberculosis: An Official ATS/CDC/ERS/IDSA Clinical Practice Guideline. Am J Respir Crit Care Med. 2025;211(1):15-33. 

Gandhi RT, Landovitz RJ, Sax PE, Smith DM, Springer SA, Gunthard HF, et al. Antiretroviral Drugs for Treatment and Prevention of HIV in Adults: 2024 Recommendations of the International Antiviral Society-USA Panel. JAMA. 2025;333(7):609-28. PubMed PMID: 39616604.

Davis JPE, Lim JK, Francis FF, Ahn J. AGA Clinical Practice Update on Management of Portal Vein Thrombosis in Patients With Cirrhosis: Expert Review. Gastroenterology. 2025;168(2):396-404. PubMed PMID: 39708000.

Drazner MH, Bozkurt B, Cooper LT, Aggarwal NR, Basso C, et al. 2024 ACC Expert Consensus Decision Pathway on Strategies and Criteria for the Diagnosis and Management of Myocarditis: A Report of the American College of Cardiology Solution Set Ove