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Bringing Gamma Back, Again

Bringing Gamma Back, Again

Update: 2020-09-1171
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Description

Today, we return to the lab of neuroscientist Li-Huei Tsai, which brought us one of our favorite stories from four years ago - about the power of flashing lights on an Alzheimer’s-addled (mouse) brain. In this update, Li-Huei tells us about her team’s latest research, which now includes flashing sound, and ways in which light and sound together might retrieve lost memories. This new science is not a cure, and is far from a treatment, but it’s a finding so … simple, you won’t be able to shake it. Come join us for a lab visit, where we’ll meet some mice, stare at some light, and come face-to-face with the mystery of memory. We can promise you: by the end, you’ll never think the same way about Christmas lights again. Or jingle bells.


This update was reported by Molly Webster, and produced by Rachael Cusick. The original episode was produced by Annie McEwen, Matt Kielty, and Molly Webster, with help from Simon Adler. 


Special thanks to Ed Boyden, Cognito Therapeutics, Brad Dickerson, Karen Duff, Zaven Khachaturian, Michael Lutz, Kevin M. Spencer, and Peter Uhlhaas.


Support Radiolab by becoming a member today at Radiolab.org/donate.    


Molly's note about the image:


Those neon green things in the image are microglia, the brain’s immune cells, or, as we describe them in our episode, the janitor cells of the brain. Straight from MIT’s research files, this image shows microglia who have gotten light stimulation therapy (one can only hope in the flicker room). You can see their many, super-long tentacles, which would be used to feel out anything that didn’t belong in the brain. And then they’d eat it!


Further reading: 


Li-Huei and co’s gamma sound and light paperMulti-sensory Gamma Stimulation Ameliorates Alzheimer’s-Associated Pathology and Improves Cognition


 


Comments (5)

Anina

she told you how to pronounce her name, please make an effort to get it right

Oct 28th
Reply

hollarhooter

why don't we see this technology or at least some more research

Sep 22nd
Reply

David

I can't stand being talked to like a five year old. Except that's not fair, because I don't condescend to five year olds anywhere near as much as this podcast does. Im tired of the hosts pretending like they don't know anything, like what a neuron is. Who is this podcast for? What kind of person is interested in brain frequencies but needs an analogy to introduce, define, and explain what neurons are to them? I don't get it. I listen to hundreds of podcasts. None of them do this. Bizarre.

Sep 16th
Reply (1)

Paul Madrid

I wonder what would happen if they also tried the other senses 🤔

Sep 16th
Reply
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Bringing Gamma Back, Again

Bringing Gamma Back, Again

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