DiscoverCounselor Toolbox PodcastCBD In Treatment of Alzheimers, Addictions and Mood Disorders
CBD In Treatment of Alzheimers, Addictions and Mood Disorders

CBD In Treatment of Alzheimers, Addictions and Mood Disorders

Update: 2020-07-071
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CBD In Treatment of Alzheimers, Addictions and Mood Disorders

Instructor: Dr. Dawn-Elise Snipes LPC-MHSP, LMHC, CCDRC

Executive Director: AllCEUs

Host: Counselor Toolbox and Happiness Isn’t Brain Surgery Podcasts


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Continuing education Credits for this podcast are available at https://www.allceus.com/member/cart/index/product/id/1308/c/


CBD In Treatment of Alzheimer’s, Addictions and Mood Disorders

Dr. Dawn-Elise Snipes


Objectives

– CBD and Addiction

– CBD and mental health issues

– CBD and neurodegenerative issues

– CBD adverse events, toxicity and drug interactions


CBD and Substance Use Disorder

– Cannabidiol's Promise for Treatment of Substance Use Disorder

– Recent models implicate major brain circuits involved in reward saliency, motivation, and memory/learned associations in maintaining addiction (7). Critically, these circuits may largely be modulated by the endocannabinoid system (ECS)

– Endocannabinoid system (ECS) modulates dopamine

– Alcohol, Nicotine and THC all increase dopamine release via nerve terminals modulated by the ECS

– ECS (Including receptor CB1R) represents a necessary contributor toward cellular adaptations in the transition from recreational substance use to a use disorder

– ECS-mediated synaptic plasticity may facilitate emotional learning and memory processes increasing emotional response to substance-related cues

– Antagonism of CB1R reduces alcohol-induced sensitization and nicotine relapse

– CBD is non-rewarding, and acts on a number of receptor systems including the opioid, serotonergic and cannabinoid (CB1R antagonist) systems.

– Systemically administered CBD regulates mesolimbic DA activity, and potentially attenuate substance-induced dysregulation

– Treatment with CBD blocked the rewarding effects of morphine and heroin and prevented drug and stress-induced reinstatement of conditioned place preference (CPP) lasting up to 2 weeks post-administration


CBD and Alcoholism

– CBD reduces

– The overall level of alcohol intake

– Motivation for ethanol

– Anxiety

– Impulsivity

– Alcohol-related steatosis and fibrosis in the liver by reducing lipid accumulation, stimulating autophagy, modulating inflammation

– Oxidative stress, and by inducing death of activated hepatic stellate cells.

– Alcohol-related brain damage, preventing neuronal loss by its antioxidant and immunomodulatory properties.

Stimulant Use Disorders

– CBD has reversed

– Toxicity and seizures induced by cocaine

– Behavioural sensitization induced by amphetamines

– Motivation to self-administer cocaine and METH

– CBD also increased the extinction of cocaine- and amphetamine-induced conditioned place preference (CPP)

– Mechanisms involved in the protective effects of CBD on addiction to psychostimulant drugs include

– Prevention of drug-induced neuroadaptations

– Erasure of aberrant drug-memories

– Elimination of cognitive deficits induced by psychostimulant drugs

– Alleviation of mental disorders comorbid with psychostimulant abuse

Cannabis and Mental Health Disorders

– Anxiety, social anxiety , depression (esp anxiety related) reduction

– CBD has many additional targets within and beyond the endocannabinoid system, including activation of 5-HT receptors, –adrenoceptors and –opioid receptors

– CBD has opposite effects of THC in the Prefrontal Cortex and amygdala

– CBD, either as monotherapy or added to regular antipsychotic medication, improved symptoms in patients with schizophrenia, with promising effects in the early stages of illness

PTSD

– 91% experienced a decrease in PTSD symptom severity, as evidenced by a lower PCL-5 score at 8 weeks than at their initial baseline. T

Alzheimer’s and Dementia

– Cannabidiol (CBD) is a phytocannabinoid which is helpful as an anxioxidant to reduce oxidative stress, an anti-inflammatory and an agonist of dopamine and serotonin

– Alzheimer’s and Parkinson’s are both characterized by inflammation and oxidative stress.

– CBD is also helpful in patients with epilepsy, restless legs and multiple sclerosis

– CBD did not negatively alter cardiovascular parameters, body temperature, psychomotor, psychological functions, nor did it induce catalepsy (trance or seizure like state) like delta-9-THC

Alzheimer’s and Dementia

– Based on its pharmacology (Russo and Marcu, 2017),CBD may be useful for

– Agitation

– Anxiety

– Psychosis

– Aggression

– Depression

– Pain

– Neuroprotection

– Reduced A-plaque formation

Inflammation

– Pain

– Autoimmune

Cannabidiol Adverse Effects and Toxicity

– CBD AEs at doses higher than recommended for human consumption included

– Developmental toxicity

– Embryo-fetal mortality

– Central nervous system inhibition

– Neurotoxicity

– Hepatocellular injuries & hepatic abnormalities

– Spermatogenesis reduction

– Male reproductive system alterations

– Hypotension

– Diarrhea, vomiting

– Fatigue

CBD Adverse Effects

– Cannabis and CBD use are rising amongst pregnant women. An estimated 4% – 20% of 18- to 24-year-old pregnant women reported using cannabis products

– CBD inhibits embryo implantation and placenta development

– Prenatal cannabinoid exposure potentiates the teratogenic effects of alcohol increasing the risk of the development of FASDs and craniofacial malformations and eye defects

Cannabidiol Adverse Effects and Toxicity

– Drug-drug interactions

– Drugs with the grapefruit warning

– Steroids and corticosteroids (asthma, arthritis and inflammatory conditions)

– Statins (cholesterol)

– Calcium channel blockers (blood pressure)

– Antihistamines

– HIV antivirals & immune modulators

– Benzodiazepines

– Antidepressants medications and herbs (acting on serotonin or dopamine)

– Anticonvulsants (i.e. Clonazepam)

– Beta-blockers (blood pressure)

– Proton-pump inhibitors (stomach acid)

– Oral diabetic medications


Summary

– CBD is showing promise as an alternative or adjunctive treatment for a variety of ailments ranging from Alzheimer’s and Addiction to Parkinson’s and Schizophrenia.

– CBD does not have the psychogenic effects that THC does, however, THC has been found to be more effective at addressing some issues

– OTC CBD is nonstandardized so dosages, even from the same manufacturer, but in different lots may have different potencies

– CBD interacts with most medications, so it is vital to consult a physician prior to using it.

– Dosages of CBD in the literature varied widely.

– Currently there are a couple CBD based medications for the treatment of seizure disorder

– CBD oils also may have a trace of THC in them—again, in OTC formulations, it may be variable, but supposed to be less than 0.3%

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CBD In Treatment of Alzheimers, Addictions and Mood Disorders

CBD In Treatment of Alzheimers, Addictions and Mood Disorders

Charles Snipes