1. Dive into a fascinating pathology case! View our compatible YouTube channel (https://youtu.be/xPQ9w1L2Sjg?si=vfaXom7Q27RkblOU). We explore a subtotal colectomy specimen with an unusual presentation of Crohn's disease. Unlike typical cases with skip lesions, this one features a focused area of disease with distinct pseudopolyps, stricturing, and wall thickening. This challenges the traditional understanding of Crohn's distribution, highlighting the importance of careful macroscopic evaluation. We delve into the key differences between Crohn's disease and ulcerative colitis (UC), examining clinical, macroscopic, and microscopic features, including transmural inflammation and the presence of granulomas. This video offers crucial insights for medical students, pathology residents, and practicing pathology professionals, emphasizing diagnostic skills and clinical correlation. Learn about the grossing procedure, including sectioning and sampling techniques for IBD cases.

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