E642 | Lucanus Polagnoli & Stephanie Urbanski, Calm/ Storm: Digital Health, Not Hype - Building, Backing & Staying Calm Through the Cycle
Description
Welcome back to the EUVC Podcast, where we bring you the people and perspectives shaping European venture.
Today we’re joined by Lucanus Polagnoli (Founding Partner & CEO) and Stephanie Urbanski (Managing Director) of Calm/Storm — a specialist early-stage fund backing software-only digital health across Europe. Fresh off the close of Fund II, we dive into how they’ve evolved from a solo-GP experiment into a community-powered platform, why they keep the scope digital-only, and how they navigate regulation, AI and the post-COVID reality without losing the plot.
🎯 This Episode’s Themes
Same, same — but sharper: Fund II doubles down on pre-seed/seed, software-only digital health, with bigger checks and higher ownership.
Community as a product: 60+ “supporting partners” and 110+ LPs powering 100+ co-invests — founder-to-founder help on demand.
Specialist by design: Why digital health (no molecules, no hardware) lets a small fund move fast and add tangible value.
Regulation ≠ roadblock: In health, approvals can protect moats — if you have the patience and the cash plan.
AI without the buzzwords: Companion to clinicians, not a replacement; curated, longitudinal data beats generic LLM advice.
Europe’s moment (still): Later-stage money does show up now; e-prescriptions and rails are here; US health is just as complex.
Logo gravity matters: Follow-on quality (Sequoia, Balderton, Creandum et al.) is the strongest portfolio predictor.
⏱️ Here’s what’s covered
00:24 | Names & origins - how to say “Polagnoli” (and why words matter)
01:24 | Fund II - same stage/sector/geo; larger tickets (€400–500k initial), higher ownership, co-lead when conviction is high
03:30 | Supporting partners - 60+ founder-operators + LPs as an on-call help network
05:45 | Why Calm/Storm - the gap they saw in 2019; launching Feb 5, 2020, right before the pandemic wave
08:52 | Post-COVID reality - rails stayed (e-scripts, digital flows), tourists left; real followers now fund B/C rounds in Europe
11:08 | Longevity & prevention - out-of-pocket willingness, AI unlocking insights from dormant data
13:21 | Team split - Stefanie’s operator engine + community execution; Lucanus on strategy and navigation
16:10 | Why digital-only - software speed, small teams, low capex; pass on molecules/hardware for fund construction reasons
22:45 | Regulation as moat - ThinkSono’s 8-year climb on DVT ultrasound automation; Europe vs. US complexity myths
26:44 | AI in health - pattern recognition, prep and triage; risks of generic LLMs for personal diagnosis
31:10 | Adoption & incentives - public vs. private delivery, prevention economics, and Europe’s risk-capital bottleneck
36:26 | Where AI wins first - curated data, longitudinal monitoring, workflow copilots; the missing top-10 health app
42:58 | Community receipts - burnout averted, board-level engagements, LPs turning co-investors
45:27 | Portfolio & follow-ons - Nelly, Lindus, 9am Health; why “who picks you up” predicts outcomes
48:56 | Exit math & fund design - earlier liquidity via M&A/secondaries; co-lead over “winner-takes-all”; stay early-stage by choice























