EP31 – Propofol TCI Pharmacokinetics with Dr Anthony | CT10
Description
Happy New Year! I’m joined today with a very special guest and current primary exam examiner Dr Anthony. In this episode we take a in depth look at the Pharmacokinetics of Propofol TCI. Anthony has curated this talk over multiple years and starts of by explaining the main equations you should know (05:35 ). We then integrate these equations into the classic Propofol Cp vs Time graph (11:52 ). This leads us on to talking about the compartment model (20:11 ) and how this applies to the ‘Marsh’ TCI model (23:25 ). To help understand the concepts of rate constants (k) Anthony uses his bucket analogy (27:27 ). Then we apply this knowledge to understand effect site targeting (Ce) and run through some examples of differences in age (41:30 ) and weight (66:05 ). Finally, we finish with a brief look at the ‘Eleveld’ Model and the concept of Keo (72:40 ). A huge thank you to Anthony and as always if you have any feedback let me know.
Sources/Credit:
All equations/graphs/diagrams/tables – Miller’s Anesthesia 10th Edition 2025
All TCI calculations – simtiva.app
End Episode Song – “The Volatiles”
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