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Ecstasy Therapy: How MDMA became medicine

Ecstasy Therapy: How MDMA became medicine

Update: 2024-08-022
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This podcast delves into the world of MDMA-assisted therapy for PTSD, focusing on the experiences of veterans who have participated in clinical trials. The episode begins by introducing the topic of MDMA therapy and its potential legalization, highlighting the FDA's consideration of MDMA for psychotherapy and the growing support for this treatment, particularly from veterans. The podcast then features the personal stories of two veterans, Jonathan Lubbecki and Ari Pallavi, who participated in clinical trials for MDMA-assisted therapy. They share their struggles with PTSD, their experiences with traditional treatments, and the impact of MDMA therapy on their lives. The episode also discusses the history of MDMA and its association with the psychedelic movement, introducing MAPS (Multidisciplinary Association for Psychedelic Studies) and its founder, Rick Doblin, who advocates for the medicinal use of psychedelics. The podcast explains MAPS' strategy to gain FDA approval for MDMA therapy by focusing on veterans with PTSD. The podcast provides a detailed account of the MDMA therapy trial process, including the screening, intake, and therapy sessions. It describes the physical effects of MDMA and the therapeutic approach used in the trials. Jonathan Lubbecki's personal experience with the therapy is highlighted, emphasizing the sense of safety and emotional processing he experienced. The episode explores the placebo effect in MDMA therapy trials, with Ari Pallavi's experience raising questions about the effectiveness of the therapy and the role of expectations in the trial results. The podcast emphasizes the importance of the entire therapeutic process, including preparation, integration, and follow-up, in addition to the psychedelic experience itself. The podcast focuses on Jonathan Lubbecki's advocacy efforts to promote MDMA therapy for PTSD, highlighting his efforts to reach out to Republicans, who are more likely to be receptive to his message as a veteran. The episode discusses the challenges Jonathan Lubbecki faces in his advocacy work, including the historical association of psychedelics with the counterculture and the government's reluctance to approve MDMA therapy due to its past reputation. The podcast explores the debate surrounding decriminalization and its impact on MDMA therapy. Jonathan Lubbecki opposes decriminalization, arguing that it undermines the focus on medical use and potentially hinders the approval process for MDMA therapy. The episode examines the current state of MDMA therapy and its future prospects, highlighting the growing public support for psychedelics as medicine, the increasing number of PTSD patients seeking this treatment, and the potential for MDMA therapy to become a widely accepted medical intervention.

Outlines

00:00:00
MDMA-Assisted Therapy for PTSD and its Potential Legalization

This chapter introduces the topic of MDMA-assisted therapy for PTSD and its potential legalization. It highlights the FDA's consideration of MDMA for psychotherapy and the growing support for this treatment, particularly from veterans who have experienced its benefits.

00:02:15
Veterans' Experiences with MDMA-Assisted Therapy

This chapter delves into the personal stories of two veterans, Jonathan Lubbecki and Ari Pallavi, who participated in clinical trials for MDMA-assisted therapy. It explores their struggles with PTSD, their experiences with traditional treatments, and the impact of MDMA therapy on their lives.

00:05:35
The Psychedelic Renaissance, MAPS, and the Advocacy for MDMA Therapy

This chapter discusses the history of MDMA and its association with the psychedelic movement. It introduces MAPS (Multidisciplinary Association for Psychedelic Studies) and its founder, Rick Doblin, who advocates for the medicinal use of psychedelics. The chapter explains MAPS' strategy to gain FDA approval for MDMA therapy by focusing on veterans with PTSD.

00:07:47
The MDMA Therapy Trial Experience and its Impact on Veterans

This chapter provides a detailed account of the MDMA therapy trial process, including the screening, intake, and therapy sessions. It describes the physical effects of MDMA and the therapeutic approach used in the trials. Jonathan Lubbecki's personal experience with the therapy is highlighted, emphasizing the sense of safety and emotional processing he experienced.

Keywords

MDMA


MDMA, also known as ecstasy or molly, is a synthetic drug that produces feelings of euphoria, empathy, and increased energy. It is currently illegal in most countries but is being investigated for its potential therapeutic benefits, particularly for treating PTSD.

PTSD


PTSD (Post-Traumatic Stress Disorder) is a mental health condition that can develop after a traumatic event. Symptoms include flashbacks, nightmares, avoidance of triggers, and difficulty concentrating. MDMA-assisted therapy is being explored as a potential treatment for PTSD.

MAPS


MAPS (Multidisciplinary Association for Psychedelic Studies) is a non-profit organization dedicated to researching and advocating for the therapeutic use of psychedelics. They have been instrumental in conducting clinical trials for MDMA-assisted therapy for PTSD.

Psychedelic Renaissance


The Psychedelic Renaissance refers to the renewed interest in the therapeutic potential of psychedelics, including MDMA, LSD, and psilocybin. This movement is driven by scientific research, personal experiences, and a growing awareness of the limitations of traditional mental health treatments.

Veteran Suicide


Veteran suicide is a significant public health issue, with veterans experiencing higher rates of suicide than the general population. MDMA-assisted therapy is being explored as a potential intervention to reduce veteran suicide rates.

Placebo Effect


The placebo effect refers to the psychological and physiological benefits experienced by individuals who believe they are receiving a treatment, even if it is inactive. In MDMA therapy trials, the placebo effect can be a confounding factor, making it difficult to determine the true effectiveness of the drug.

FDA


The FDA (Food and Drug Administration) is a government agency responsible for regulating food, drugs, and medical devices in the United States. They are currently considering whether to approve MDMA for use in psychotherapy for PTSD.

Decriminalization


Decriminalization refers to the removal of criminal penalties for possession of a substance, while still maintaining some form of regulation. The debate over decriminalization of MDMA is complex, with some advocates arguing that it would increase access to the drug for therapeutic purposes, while others believe it could hinder the approval process for MDMA therapy.

Q&A

  • What are the potential benefits of MDMA-assisted therapy for PTSD?

    MDMA-assisted therapy has shown promise in reducing PTSD symptoms, particularly in veterans. It can help individuals process traumatic memories, reduce fear and anxiety, and increase feelings of empathy and connection.

  • How does MDMA therapy work?

    MDMA therapy involves taking MDMA under the guidance of trained therapists. The drug helps to reduce fear and anxiety, allowing individuals to access and process traumatic memories in a safe and supportive environment.

  • What are the risks associated with MDMA therapy?

    MDMA can cause side effects such as increased heart rate, blood pressure, and sweating. It is important to use MDMA under the supervision of qualified professionals to minimize risks.

  • What are the challenges to legalizing MDMA therapy?

    Legalizing MDMA therapy faces challenges related to its historical association with the counterculture, concerns about potential misuse, and the need for rigorous scientific evidence to support its effectiveness.

  • What is the role of the FDA in the legalization of MDMA therapy?

    The FDA is responsible for approving new drugs and therapies. They are currently reviewing the evidence for MDMA therapy and will ultimately decide whether to approve it for use in psychotherapy for PTSD.

  • What is the future of MDMA-assisted therapy?

    The future of MDMA therapy is uncertain, but there is growing support for its potential as a treatment for PTSD. Continued research, advocacy efforts, and public awareness are crucial for advancing the legalization and accessibility of this therapy.

Show Notes

Military veterans are unlikely collaborators with the psychedelic counterculture. The two groups’ efforts are being tested this month, when the FDA is poised to announce whether or not it’ll approve MDMA for PTSD.

This episode was reported and produced by Haleema Shah, edited by Lissa Soep and Matt Collette, fact-checked by Laura Bullard, engineered by Andrea Kristinsdottir and Rob Byers, and hosted by Sean Rameswaram. It’s the second in a series supported with a grant from the Ferriss–UC Berkeley Psychedelic Journalism Fellowship.

Transcript at vox.com/today-explained-podcast

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Ecstasy Therapy: How MDMA became medicine

Ecstasy Therapy: How MDMA became medicine

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