On November 20, 2025 we met with Dr. Cristian Lasagna-Reeves to talk about tau protein, its normal function, and what is known about how it aggregates to form the tangles seen in a variety of neurodegenerative brain conditions. We discussed the problem of determining whether the aggregates were causes or effects of the disease process, and whether reducing expression of tau might be an effective treatment.

Guest:

Cristian Lasagna-Reeves, Associate Professor, Dept. of Neurology, Baylor College of Medicine

Participating:

George Perry, Department of Neuroscience, Developmental and Regenerative Biology, UT San Antonio

Hyoung-gon Lee, Department of Neuroscience, Developmental and Regenerative Biology, UT San Antonio

Host:

Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UT San Antonio

Thanks to Jim Tepper for original music