“Although the patient is spending a little less time in the clinic, the administration actually requires the nurse to be at the chairside the entire time. This has allowed nurses to spend potentially uninterrupted time to sit and converse with the patients that they may not have had with an IV infusion. It’s been a wonderful unintentional outcome from the development of the large-volume subcutaneous injections,” Crystal Derosier, MSN, RN, OCN^®, clinical specialist at Dana-Farber Cancer Institute, in Boston, MA, told Jaime Weimer, MSN, RN, AGCNS-BS, AOCNS^®, manager of oncology nursing practice at ONS, during a conversation about administering high-volume subcutaneous injections in cancer care.

Music Credit: “Fireflies and Stardust” by Kevin MacLeod

Licensed under Creative Commons by Attribution 3.0 

Earn 0.5 contact hours of nursing continuing professional development (NCPD) by listening to the full recording and completing an evaluation at courses.ons.org by November 22, 2026. The planners and faculty for this episode have no relevant financial relationships with ineligible companies to disclose. ONS is accredited as a provider of nursing continuing professional development by the American Nurses Credentialing Center’s Commission on Accreditation.

Learning outcome: The learner will report an increase in knowledge related to the administration of high-volume subcutaneous injections.

Episode Notes 

• Complete this evaluation for free NCPD. 
• Oncology Nursing Podcast™ episodes:
  • Episode 326: Intramuscular Injections: The Oncology Nurse’s Role
  • Episode 285: Transarterial Chemoembolization: The Oncology Nurse’s Role
  • Episode 271: Intraventricular and Intrathecal Administration: The Oncology Nurse’s Role
  • Episode 265: Intravesical Administration: The Oncology Nurse’s Role
  • Episode 252: Intraperitoneal Administration: The Oncology Nurse’s Role
• ONS Voice articles:
  • Administration Considerations Amid the Large-Volume Subcutaneous Injection Revolution
  • FDA Approves Atezolizumab and Hyaluronidase-Tqjs for Subcutaneous Injection
  • Make Subcutaneous Administration More Comfortable for Your Patients
  • Oncology Drug Reference Sheet: Pertuzumab, Trastuzumab, and Hyaluronidase-Zzxf Subcutaneous Injection
  • ONS Voice Oncology Drug Reference Sheets
• ONS book: Access Device Guidelines: Recommendations for Nursing Practice and Education (Fourth Edition)
• ONS course: ONS/ONCC Chemotherapy Immunotherapy Certificate™
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