What happens when a music executive’s precision meets a life-changing diagnosis?

In this candid episode of All Talk Oncology, Kenny Perkins sits down with Mathew Knowles—music executive, author of The DNA of Achievers, and male breast cancer survivor. A tiny sign on a white T-shirt (nipple discharge) led Mathew to insist on a mammogram, a Stage 1A diagnosis, surgery, and the discovery of a BRCA2 variant. Drawing on his 20-year background in medical imaging, he breaks down early detection, building a winning care team, and why he now lives by quarterly labs, therapy, movement, and joy. From COVID-era anxiety to laughter-filled nights with his wife, Mathew shares the mindset shifts and habits that helped him rebuild a life he loves—one mindful walk and measured plate at a time.

• Men get breast cancer: the overlooked red flags (nipple discharge) and why Mathew demanded a mammogram


• BRCA2 explained: risk implications for men (melanoma, pancreatic, prostate, male breast cancer) and for women (breast, gynecologic)


• Diagnosed at Stage 1A: survival odds, surgery, and five years on Tamoxifen


• From isolation to a care team: oncologist, therapist, spiritual support—and why isolation increases risk


• COVID anxiety & mental health: therapy to confront fear of dying and regain balance


• Diet, weight loss (~40 lbs), and daily 2-mile brisk walks—“cancer loves obesity”


• Portion control and practical nutrition: measuring plates, lighter foods, consistent habits


• Quarterly labs for peace of mind (not just annual checkups); self-advocacy with your clinicians


• “Look out the window”: stillness, nature, laughter, and marriage strengthened through survivorship


• Family history & genetics: why genetic testing + knowing your lineage should start early

Men’s health advocacy: PSA tests, breaking cultural conditioning, and getting over outdated fears

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