In today's episode of Tripping Over Love, we sit down with Dr. John Krystal—Chair of Psychiatry at Yale and one of the pioneers behind ketamine's use in treating depression.

If you've ever wondered how ketamine actually works, why it's so different from SSRIs, what happened with MDMA's FDA rejection, or whether esketamine is truly better than IV ketamine…this is the episode.

Dr. Krystal explains:

How ketamine became the first rapid-acting antidepressant
Why it works when nothing else does
The real difference between IV ketamine and esketamine (Spravato)
How few people with treatment-resistant depression actually receive ketamine
Why supervised clinical use is essential
What the future of mental health treatment looks like (next-gen ketamine & non-hallucinogenic psychedelics)

We also talk openly about our own mental health journeys—including how ketamine changed Keith's life and inspired the founding of a ketamine-assisted therapy clinic.

This episode blends science, safety, personal experience, and the emerging landscape of psychedelic medicine.

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