00:00:00 Introduction de l'épisode sur le jeûne avec Axel
00:01:15 Présentation d'Axel Sedano, diététicien
00:02:30 Définition du jeûne
00:04:00 Types de jeûne expliqués
00:06:45 Popularité du jeûne intermittent
00:09:00 Impact du repas sauté dans le jeûne intermittent
00:11:30 Effets similaires du jeûne et de la restriction calorique
00:13:45 Jeûne pour raisons religieuses ou idéologiques
00:15:00 Autophagie et nettoyage cellulaire
00:18:30 Détoxification et jeûne: faits et mythes
00:21:00 Approches basées sur des preuves pour la santé du foie
00:23:00 Effets du jeûne intermittent sur la santé métabolique
00:26:00 Impact du jeûne sur la perte de poids et l'exercice
00:29:00 Jeûne et gain musculaire
00:31:30 Jeûne et santé digestive
00:34:00 Impact du jeûne sur le microbiome
00:36:30 Jeûne et vieillissement
00:38:00 Jeûne et cancer: tolérance à la chimiothérapie
00:41:00 Effet Warburg et cellules tumorales
00:44:00 Recommandations médicales pour le jeûne
00:46:00 Sources fiables d'information sur le jeûne
00:48:00 Dangers du jeûne et pratiques sectaires
00:50:00 Recommandations de lecture et suivi d'Axel



Retrouvez Axel sur instagram :
https://www.instagram.com/sedanoaxel/







Resources :



1) Risque des Cures de jeûne et emprise sectaire :



Afis Science - Association française pour l’information scientifique. (2015.). https://www.afis.org/Cures-detox-intox
Bras, L. (2021, August 4). Jeûne extrême, crudivorisme. . . Les pratiques sectaires santé et bien-être en forte augmentation. Ouest-France.fr. https://www.ouest-france.fr/societe/crudivorisme-jeune-extreme-les-pratiques-sectaires-sante-et-bien-etre-en-forte-augmentation-09290636-f437-11eb-be44-3c3b5e3aae9e
Laurent, S. (2023, January 14). Un naturopathe promoteur du jeûne mis en examen pour « homicide involontaire ». Le Monde.fr. https://www.lemonde.fr/societe/article/2023/01/13/un-naturopathe-promoteur-du-jeune-mis-en-examen-pour-homicide-involontaire_6157797_3224.html





2) Études et méta-analyses sur la perte de poids et les marqueurs cardio-métaboliques :



Allaf, M., Elghazaly, H., Mohamed, O. G., Fareen, M. F. K., Zaman, S., Salmasi, A., Tsilidis, K., & Dehghan, A. (2021). Intermittent fasting for the prevention of cardiovascular disease. Cochrane Library, 2021(3). https://doi.org/10.1002/14651858.cd013496.pub2
Chen, J., Lu, L. W., Ge, Q., Feng, D., Yu, J., Liu, B., Zhang, R., Zhang, X., Ouyang, C., & Chen, F. (2021). Missing puzzle pieces of time-restricted-eating (TRE) as a long-term weight-loss strategy in overweight and obese people? A systematic review and meta-analysis of randomized controlled trials. Critical Reviews in Food Science and Nutrition, 63(15), 2331–2347. https://doi.org/10.1080/10408398.2021.1974335
Schroor, M. M., Joris, P. J., Plat, J., & Mensink, R. P. (2023). Effects of Intermittent Energy Restriction Compared with Those of Continuous Energy Restriction on Body Composition and Cardiometabolic Risk Markers – A Systematic Review and Meta-Analysis of Randomized Controlled Trials in Adults. Advances in Nutrition, 100130. https://doi.org/10.1016/j.advnut.2023.10.003



Silverii, G. A., Cresci, B., Benvenuti, F., Santagiuliana, F., Rotella, F., & Mannucci, E. (2023). Effectiveness of intermittent fasting for weight loss in individuals with obesity: A meta-analysis of randomized controlled trials. Nutrition Metabolism and Cardiovascular Diseases, 33(8), 1481–1489.
https://doi.org/10.1016/j.numecd.2023.05.005





Sun, M., Yao, W., Wang, X., Gao, S., Varady, K. A., Forslund, S. K., Zhang, M., Shi, Z., Cao, F., Zou, B., Sun, M., Liu, K., Bao, Q., Xu, J., Qin, X., Xiao, Q., Wu, L., Zhao, Y., Zhang, D., . . . Gong, T. (2024). Intermittent fasting and health outcomes: an umbrella review of systematic reviews and meta-analyses of randomised controlled trials. EClinicalMedicine, 70, 102519. https://doi.org/10.1016/j.eclinm.2024.102519
Sutton, E. F., Beyl, R., Early, K. S., Cefalu, W. T., Ravussin, E., & Peterson, C. M. (2018). Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes. Cell Metabolism, 27(6), 1212-1221.e3. https://doi.org/10.1016/j.cmet.2018.04.010
Varady, K. A., Cienfuegos, S., Ezpeleta, M., & Gabel, K. (2022). Clinical application of intermittent fasting for weight loss: progress and future directions. Nature Reviews Endocrinology, 18(5), 309–321. https://doi.org/10.1038/s41574-022-00638-x
Xie, Y., Zhou, K., Shang, Z., Bao, D., & Zhou, J. (2024). The Effects of Time-Restricted Eating on Fat Loss in Adults with Overweight and Obese Depend upon the Eating Window and Intervention Strategies: A Systematic Review and Meta-Analysis. Nutrients, 16(19), 3390. https://doi.org/10.3390/nu16193390





3) Meta-analyses sur le jeûne et le stress oxydatif et l’inflammation:



Mohr, A. E., McEvoy, C., Sears, D. D., Arciero, P. J., & Sweazea, K. L. (2021). Impact of intermittent fasting regimens on circulating markers of oxidative stress in overweight and obese humans: A systematic review of randomized controlled trials. Advances in Redox Research, 3, 100026. https://doi.org/10.1016/j.arres.2021.100026
Turner, L., Charrouf, R., Martínez-Vizcaíno, V., Hutchison, A., Heilbronn, L. K., & Fernández-Rodríguez, R. (2023). The effects of time-restricted eating versus habitual diet on inflammatory cytokines and adipokines in the general adult population: a systematic review with meta-analysis. American Journal of Clinical Nutrition, 119(1), 206–220. https://doi.org/10.1016/j.ajcnut.2023.10.009
Wang, X., Yang, Q., Liao, Q., Li, M., Zhang, P., Santos, H. O., Kord-Varkaneh, H., & Abshirini, M. (2020). Effects of intermittent fasting diets on plasma concentrations of inflammatory biomarkers: A systematic review and meta-analysis of randomized controlled trials. Nutrition, 79–80, 110974. https://doi.org/10.1016/j.nut.2020.110974





4) Études sur le sport à jeun et sur la prise de muscle :



Keenan, S., Cooke, M. B., & Belski, R. (2020). The Effects of Intermittent Fasting Combined with Resistance Training on Lean Body Mass: A Systematic Review of Human Studies. Nutrients, 12(8), 2349. https://doi.org/10.3390/nu12082349
Keenan, S. J., Cooke, M. B., Hassan, E. B., Chen, W. S., Sullivan, J., Wu, S. X., El-Ansary, D., Imani, M., & Belski, R. (2022). Intermittent fasting and continuous energy restriction result in similar changes in body composition and muscle strength when combined with a 12 week resistance training program. European Journal of Nutrition, 61(4), 2183–2199. https://doi.org/10.1007/s00394-022-02804-3
Tinsley, G. M., Moore, M. L., Graybeal, A. J., Paoli, A., Kim, Y., Gonzales, J. U., Harry, J. R., VanDusseldorp, T. A., Kennedy, D. N., & Cruz, M. R. (2019). Time-restricted feeding plus resistance training in active females: a randomized trial. American Journal of Clinical Nutrition, 110(3), 628–640. https://doi.org/10.1093/ajcn/nqz126
Tremblay, A., Simoneau, J., & Bouchard, C. (1994). Impact of exercise intensity on body fatness and skeletal muscle metabolism. Metabolism, 43(7), 814–818. https://doi.org/10.1016/0026-0495(94)90259-3
Schoenfeld, B. J., Aragon, A. A., Wilborn, C. D., Krieger, J. W., & Sonmez, G. T. (2014). Body composition changes associated with fasted versus non-fasted aerobic exercise. Journal of the International Society of Sports Nutrition, 11(1). https://doi.org/10.1186/s12970-014-0054-7



5) Études sur les maladies digestives :



Études chez l’animal : 
Song, S., Bai, M., Ling, Z., Lin, Y., Wang, S., & Chen, Y. (2021). Intermittent administration of a fasting-mimicking diet reduces intestinal inflammation and promotes repair to ameliorate inflammatory bowel disease in mice. The Journal of Nutritional Biochemistry, 96, 108785. https://doi.org/10.1016/j.jnutbio.2021.108785



Rapport de cas chez l'homme et les MICI :
Roco-Videla, Á., Villota-Arcos, C., Pino-Astorga, C., Mendoza-Puga, D., Bittner-Ortega, M., & Corbeaux-Ascui, T. (2023). Intermittent Fasting and Reduction of Inflammatory Response in a Patient with Ulcerative Colitis. Medicina, 59(8), 1453. https://doi.org/10.3390/medicina59081453



6) Rapports et méta-analyses sur le jeûne et le cancer :



Clifton, K. K., X, C., MA, Fontana, L., & Peterson, L. L. (2021). Intermittent fasting in the prevention and treatment of cancer. CA a Cancer Journal for Clinicians, 71(6), 527–546. https://doi.org/10.3322/caac.21694
De Groot, S., Vreeswijk, M. P., Welters, M. J., Gravesteijn, G., Boei, J. J., Jochems, A., Houtsma, D., Putter, H., Van Der Hoeven, J. J., Nortier, J. W., Pijl, H., & Kroep, J. R. (2015). The effects of short-term fasting on tolerance to (neo) adjuvant chemotherapy in HER2-negative breast cancer patients: a randomized pilot study. BMC Cancer, 15(1). https://doi.org/10.1186/s12885-015-1663-5
Drexler, U., Dörfler, J., Von Grundherr, J., Erickson, N., & Hübner, J. (2022). Fasting during cancer treatment: a systematic review. Quality of Life Research, 32(5), 1427–1446. https://doi.org/10.1007/s11136-022-03300-1
NACRe. (2017). Rapport NACRe jeune regimes restrictifs cancer 2017. https://www.reseaunacre.eu/actualites/rapport-nacre-jeune-regimes-restrictifs-cancer-2017
Stringer, E. J., Cloke, R. W. G., Van Der Meer, L., Murphy, R. A., Macpherson, N. A., & Lum, J. J. (2024). The Clinical Impact of time-restricted eating on Cancer: A Systematic review. Nutrition Reviews. https://doi.org/10.1093/nutrit/nuae105



Études sur les régimes qui imittent le jeûne :
De Groot, S., Lugtenberg, R. T., Cohen, D., Welters, M. J. P., Ehsan, I., Vreeswijk, M. P. G., Smit, V. T. H. B. M., De Graaf, H., Heijns, J. B., Portielje, J. E. A., Van De Wouw, A. J., Imholz, A. L. T., Kessels, L. W., Vrijaldenhoven, S., Baars, A., Kranenbarg, E. M., Carpentier, M. D., Putter, H., Van Der Hoeven, J. J. M., . . . Kroep, J. R. (2020). Fasting mimicking diet as an adjunct to neoadjuvant chemotherapy for breast cancer in the m