DiscoverHigh Intensity Health with Mike Mutzel, MSLongevity Drugs You Should Consider for Immune Health
Longevity Drugs You Should Consider for Immune Health

Longevity Drugs You Should Consider for Immune Health

Update: 2021-11-03
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Description

Metformin and Rapamycin, two popular longevity drugs, have been shown to support immune health in elderly and high-risk subjects as well as decrease mortality in persons infected with COVID-19.

We discuss the science and rationale for prophylactic blood sugar health support in non-diabetics for longevity and immune health. 

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Related Podcast: Latest Breakthroughs In the Biology of Aging with Matt Kaeberlein, PhD

 

Time Stamps:


0:00 intro
0:38 mTOR inhibitors
1:15 Low Side effect profile
2:19 Metformin and influenza
2:50 Metabolic and immune health are one in the same
3:15 Aging and Immune Competence
3:52 Microdosing mTOR inhibitors
4:31 Dog Aging Project
5:07 Aging and Immunity
6:10 T Cells are Essential
6:55 Metformin was initially helpful for Influenza
8:11 Why chronic inflammation is bad
9:39 Pulsing mTOR inhibitors
13:38 Electrolytes and Creatine
14:19 Drugs are not always bad
15:28 Poor blood sugar control is a problem
18:20 Metformin and B Vitamins
19:15 Metformin and C*19

 

Articles Mentioned:

Bischof, E., C Siow, R., Zhavoronkov, A., & Kaeberlein, M. (2021). The potential of rapalogs to enhance resilience against SARS-CoV-2 infection and reduce the severity of COVID-19. The Lancet Healthy Longevity, 2(2), e105–e111. http://doi.org/10.1016/S2666-7568(20)30068-4

 

Bramante, C. T., Buse, J., Tamaritz, L., Palacio, A., Cohen, K., Vojta, D., et al. (2021). Outpatient metformin use is associated with reduced severity of COVID-19 disease in adults with overweight or obesity. Journal of Medical Virology, 93(7), 4273–4279.

Kruglikov, I. L., Shah, M., Elife, P. S.,. (2020). Obesity and diabetes as comorbidities for COVID-19: Underlying mechanisms and the role of viral–bacterial interactions. Elifesciences.org.

metabolism, A. S. D.,. (2020). Metformin and COVID-19: from cellular mechanisms to reduced mortality. Nutrition, Metabolism and Cardiovascular Diseases. http://doi.org/10.1016/j.diabet.2020.07.006

 

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Longevity Drugs You Should Consider for Immune Health

Longevity Drugs You Should Consider for Immune Health