I start this podcast by describing Memorial Day in America, then tie this idea into what is happening in the equine veterinary profession. I only dwell on this briefly because there are more upbeat things to discuss, such as the Klotho protein.

The Klotho protein was discovered from an experimental failure and found in all animals. This protein, made up of one thousand amino acids, is primarily produced by the kidneys. A portion of it is then released from the cell, acting as a hormone that can influence cells in distant locations, including the brain.

Klotho affects platelets, causing them to release PF4, one of many platelet factors. PF4 stimulates the brain's synapses in 4 hours, causing a profound increase in cognitive functions lasting for 19 days or more after administering it to mice and primates. The hope is that giving this protein will reduce or eliminate cognitive decline, dementia, and Alzheimer's disease in humans.

An even more exciting result is the reduction of "all-cause mortality" in mice and primates after raising the amounts of Klotho. Could this also be true in horses? The best way to increase Klotho is exercise, which causes a 30% increase. Feeding adequate amounts of high-quality protein may also help increase Klotho.

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