Methotrexate and the COVID Vaccine -WARNING

Methotrexate and the COVID Vaccine -WARNING

Update: 2021-08-29


 As per the link above, individuals taking the drug methotrexate experience an up to 62% reduced rate of an immunological response when given a mRNA Covid-19 vaccination like to Pfizer and Moderna vaccines.  This finding suggests that patients on methotrexate may need alternate vaccination strategies such as additional doses of vaccine, dose modification of methotrexate or even a temporary discontinuation of this drug.

In this podcast, Joel Nowak from Cancer ABCs, who is taking methotrexate, after having is booster shot of the Moderna vaccine was informed by his doctor that he should have not received the injection without having made a modification in his methotrexate.   Joel talks about his frustration and anger that he was not informed about this complication when the research was first published, three months prior to his receiving his Covid-19 booster shot.  

 Joel shared his current plan to discontinue taking methotrexate and hope that the booster will still create some antigen effect.  He will follow up in a few weeks and check his antigen level (blood test) and then if he hasn't received an adequate result go on a campaign to obtain an additional Covid vaccination booster while still remaining off methotrexate.

Joel’s story should serve as a warning to anyone taking methotrexate that they need to discuss this issue with their doctors prior to having a mRNA Covid-19 vaccination.  

Cancer ABCs would like to thank its podcast sponsors for their support of this podcast program.  Our sponsors include:

  • Myovant/Pfizer
  • Foundation Medicine
  • Bayer 
  • Dendreon
Support the show (
In Channel
Download from Google Play
Download from App Store








Sleep Timer


End of Episode

5 Minutes

10 Minutes

15 Minutes

30 Minutes

45 Minutes

60 Minutes

120 Minutes

Methotrexate and the COVID Vaccine -WARNING

Methotrexate and the COVID Vaccine -WARNING

Joel Nowak Cancer ABCs