Pat Mayo, Tyler Tamboline, and John Breslin of 4for4 DFS Fantasy break down the best 2025 NFL Week 16 DraftKings picks, lineups, and DFS strategy to help you build winning rosters. We cover ownership projections, game stacks, top plays, fades, and Underdog Pick’em picks for Week 16. Whether you’re entering GPPs or cash games, this guide has you covered.

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Show Index

00:00 Intro

2:30 SLATE OVER OVERVIEW

4:01 OPTIMAL + ARZ/ATL

27:49 DET/PIT

34:07 NYJ/NO

46:11 MIN/NYG

50:29 HOU

57:02 DAL/LAC

1:01:09 MIA/CIN
 

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