Exploring Deep Brain Stimulation & Cognitive Function with Dr. David Blake | Neurostimulation Podcast

Join Michael Passmore, clinical associate professor in Psychiatry at the University of British Columbia, as he hosts Dr. David Blake, professor of neuroscience and regenerative medicine at Augusta University. In this episode, they delve into Dr. Blake's groundbreaking research on deep brain stimulation (DBS) and its effects on aging, cognitive function, and neuroplasticity. They discuss the latest findings presented at the 2025 Brain Stimulation Conference in Kobe, Japan, exploring the impact of DBS on neurotrophic markers in cerebrospinal fluid. This fascinating conversation unravels the potential of DBS in treating age-related cognitive decline, Alzheimer's disease, and broader applications such as Parkinson's disease and other neurocognitive disorders. Tune in to discover how Dr. Blake's interdisciplinary approach could revolutionize neurotherapeutics.

Blake Lab: https://www.augusta.edu/mcg/dnrm/faculty/blakelab.php

Cortical acetylcholine response to deep brain stimulation of the basal forebrain - Brain Stimulation Jan/Feb 2025 (Open access full text)

https://www.brainstimjrnl.com/article/S1935-861X(24)00979-3/fulltext

Intermittent stimulation of the basal forebrain improves working memoryin aged nonhuman primates Jan/Feb 2025 (Abstract)

https://www.brainstimjrnl.com/article/S1935-861X(24)00735-6/fulltext

Synchron: https://synchron.com

ECoG (Electrocorticography): https://en.wikipedia.org/wiki/Electrocorticography#:~:text=Electrocorticography%20(ECoG)%2C%20a%20type,activity%20from%20the%20cerebral%20cortex.

00:00 Introduction to the Neurostimulation Podcast

01:11 Sponsor and Guest Introduction

01:43 Deep Brain Stimulation Research Overview

04:04 Discussion with Dr. David Blake

06:27 Dr. Blake's Research and Findings

22:10 Future Directions and Applications

40:14 Brain-Computer Interfaces and Neuromodulation

45:10 Advice for Aspiring Neuroscientists

48:54 Conclusion and Farewell