Overcoming drug resistance and targeting critical pathways: Dr Larry Norton – Memorial Sloan-Kettering Cancer Center, New Yor
Update: 2012-05-29
Description
Dr Larry Norton talks to ecancer about drug resistance and targeting pathways at IMPAKT 2012 in Brussels, May 2012.
Dr Norton states that cancer research is at the point where the understanding of cancer is enough to start driving towards eradication of the disease.
While numerous pathways have been identified, there are only about ten critical pathways. Dr Norton is currently working on applying mathematics to the problem of using more than one drug in a complementary system.
The difficulty in intelligent dosing with targeted therapy is finding a balance in treatment. If treated too intensely, resistance will develop quicker, therefore treatment needs to be slow paced in order to overcome and, in some cases, prevent resistance.
Dr Norton states that cancer research is at the point where the understanding of cancer is enough to start driving towards eradication of the disease.
While numerous pathways have been identified, there are only about ten critical pathways. Dr Norton is currently working on applying mathematics to the problem of using more than one drug in a complementary system.
The difficulty in intelligent dosing with targeted therapy is finding a balance in treatment. If treated too intensely, resistance will develop quicker, therefore treatment needs to be slow paced in order to overcome and, in some cases, prevent resistance.
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