Repurposed Miracles: David Fajgenbaum on Saving Lives — Armchair Expert
Update: 2025-11-26
Description
When a doctor becomes a patient, curiosity can rewrite treatment possibilities. This condensed version distills a 2-hour Armchair Expert conversation into 6 minutes, with hosts Dax Shepard and Monica Padman interviewing physician-scientist David Fajgenbaum about using existing drugs to treat rare, life-threatening conditions. Learn how Fajgenbaum’s own battle led to identifying mTOR hyperactivity and treating it with sirolimus, the three-step blueprint for drug repurposing (read the literature, unite experts, validate with patient samples), and how Every Cure uses AI and a biomedical knowledge graph to prioritize promising drug-disease matches. Key takeaways include practical examples (POEMS, angiosarcoma, cerebral folate deficiency), the role of biomarkers, the limits of pharma incentives for generics, and strategies for clinical translation. Keywords: drug repurposing, rare disease, sirolimus, Every Cure, AI, knowledge graph, biomarkers. Listen now to get the key ideas in minutes.
Comments
In Channel
Download from Google Play
Download from App Store
United States00:00
00:00
x
