The cholinergic contribution to freezing of gait in Parkinson’s disease

Update: 2025-08-11

Description

In this episode, host Dr. Michele Matarazzo interviews Dr. Nicolaas Bohnen about his team’s recent study using FEOBV PET to investigate cholinergic deficits in Parkinson’s disease patients with dopa-unresponsive freezing of gait (FOG). The results reveal a distinct pattern of cortical cholinergic denervation that may underlie this challenging and poorly treatable symptom. Dr. Bohnen discusses the implications for subtyping FOG, the role of cholinergic systems in higher-order motor control, and the potential for cholinergic-targeted therapies.

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The cholinergic contribution to freezing of gait in Parkinson’s disease

#box-pro-ellipsis-175967573367966{-webkit-line-clamp:2;}The cholinergic contribution to freezing of gait in Parkinson’s disease

The cholinergic contribution to freezing of gait in Parkinson’s disease

The cholinergic contribution to freezing of gait in Parkinson’s disease