The history of giant cell arteritis: Infections, injections and the man who couldn't wear a hat
Update: 2025-11-25
Description
What does a goiter and syphilis have in common with the first descriptions of giant cell arteritis? Join us as we dive into the history of the most common type of vasculitis!
- Intro 0:13
- GCA at ACR 2025 00:30
- How Brown has approached framing this episode 1:01
- A primer leading us to GCA 3:15
- Let's get to the story 4:02
- The man who couldn't wear a hat 4:57
- Dr. Bayard Horton's 7:40
- A tangent on cluster headaches 8:27
- Let's get back to GCA 13:16
- The first temporal artery biopsy 14:28
- Vision loss and other puzzle pieces of GCA 16:27
- What about jaw claudication? 21:15
- Could GCA be transmissible? Injecting ground temporal arteries into healthy volunteers 24:13
- Oxygen? Histamines? Adrenal cortical extract? Looking for GCA treatments 26:55
- Steroids and GCA 28:40
- A quote from the 1959 Mayo Clinic Board of Governors 32:24
- Extracranial involvement in GCA 33:24
- When did we recognize aorta involvement? Syphilis enters the picture 35:08
- A recap of the history of GCA 41:25
- Thanks for listening 42:19
We'd love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum.
References:
Boes CJ, Cephalalgia. 2007;doi:10.1111/j.1468-2982.2007.01238.x
Cummer CL, et al. JAMA. 1912;doi:10.1001/jama.1912.04270080101004
Horton BT, Proc Cent SOC Clin Res. 1946
Sproul EE, et al. Am J Pathol. 1937;PMID: 19970328
Disclosures: Brown reports no relevant financial disclosures.
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