Join us for an in-depth conversation with William V. Giannobile, interviewed by Sejal Thacker, as he reflects on his key publication, Platelet-derived growth factor stimulates bone fill and rate of attachment level gain. Giannobile discusses the groundbreaking development of recombinant human platelet-derived growth factors (PDGFs) and their pivotal role in oral tissue regeneration. He traces PDGF's journey from discovery to clinical application, sharing insights into the science, trials and regulatory steps that brought this innovation to patients. From early tissue culture studies to regenerative therapies for periodontal disease, Giannobile details the research process and rigorous trials required to develop safe and effective treatments. This is a must for anyone interested in the latest developments in oral tissue regeneration!