When Infections Inflame the Mind: Lyme, MS, and the Gut–Brain Connection

Dr. Darin Ingels connects the dots between chronic infections (like Lyme), the gut–brain axis, and neuroinflammation—explaining “leaky gut/leaky brain,” vagus-nerve signaling, mast-cell activation, and why mood, brain fog, and sleep often shift with immune activity. He shares practical supports—from joy practices to potent, targeted herbs—and how to vet supplement quality for safety and results.

Key takeaways:

Leaky gut and “leaky brain” often travel together; restoring gut function improves brain function.

The vagus nerve can transmit gut signals that open the blood–brain barrier and drive neuro-inflammation.

In Lyme and MS, immune cross-reactivity and mast-cell activation can inflame brain and nerves, contributing to anxiety, depression, OCD, and brain fog.

Joy and regulation tools matter: music, humor, nature, and realistic activity resets help shift mental state on hard days.

Herbal medicine is multi-targeted: combinations can modulate inflammation, immunity, hormones, and circulation—often at low doses with strong effects.

Adaptogens to balance stress/cortisol: eleuthero (Siberian ginseng), rhodiola, holy basil, Ashwagandha—choose by symptom pattern (e.g., “tired-and-wired”).

Sleep supports: lemon balm, chamomile, passionflower, kava, California poppy; nutrients like magnesium and 5-HTP/L-tryptophan help with staying asleep.

Pain/inflammation options: highly bioavailable curcumin, Boswellia (frankincense), white willow bark, and devil’s claw (Harpagophytum).

Quality matters: look for GMP certification and third-party testing; request Certificates of Analysis; be cautious with heat-exposed or counterfeit online products.

Forms and safety: tinctures, capsules, teas, glycerites—many herbs are GRAS with low toxicity when sourced and dosed correctly.

Conclusion: Integrative mental health isn’t brain-only; it’s gut, immune, nerves, and daily rhythms working together. With clearer roots (infection, mast cells, barrier integrity) and practical tools (tailored herbs, joyful resets, vetted supplements), you can calm neuro-inflammation and support steadier mood, sleep, and cognition, step by step.

Host Bio:

Dr. Melissa Mondala is a triple specialist in family medicine, lifestyle medicine, and integrative/primary care psychiatry. She is double board certified in family medicine and lifestyle medicine, completed her family medicine residency and Lifestyle Medicine Fellowship at Loma Linda University Health, and earned her MD from Chicago Medical School along with master’s degrees in Health Administration and Biomedical Science. Dr. Mondala is co-founder of Dr. Lifestyle in Newport Beach, where she provides direct primary care, integrative mental health, and lifestyle-based prevention for patients locally and via telehealth.

She has served as core faculty in Preventive/Lifestyle Medicine at Loma Linda University and has contributed to national education in lifestyle medicine. She also co-hosts the Autoimmune Alchemy podcast with Dr. Micah Yu and leads the Integrative Mental Health Summit, bringing root-cause strategies for anxiety, mood, and brain health to a wider audience. Her approach blends diagnostics and conventional care with nutrition, sleep, movement, stress tools, and community to help patients reduce inflammation and build long-term resilience.