Were it not for the eventual verdict of the Court of Appeal, Holmes vs Poeton may well have been a landmark case for Parkies. Or so claims the (ex) Judge, Nicholas Mostyn, who serves as the guide in today's episode, where the Movers & Shakers look into some thorny questions: what causes Parkinson's? And who, if anyone, is to blame? Our guide is Professor Yoav Ben-Shlomo from the University of Bristol, who dissects the evidence – from controversial twin studies to a contaminated Marine encampment – and delivers his verdict on the balance of probability.

This episode was generously sponsored by Purdy & Figg. For 50% off your first starter kit, as well as a free bottle for life and cloth, click here.

Presented by Rory Cellan-Jones, Gillian Lacey-Solymar, Mark Mardell, Paul Mayhew-Archer, Sir Nicholas Mostyn and Jeremy Paxman.

Produced and edited by Nick Hilton for Podot.

Sound mixing by Ewan Cameron.

Music by Alex Stobbs.

Artwork by Till Lukat.

PR by Sally Jones.

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