Will RNA based tests form the basis for cancer screening and monitoring? Elizabeth Tracey reports
Update: 2025-10-13
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RNA is easier to detect and points toward cancer activity better than DNA testing, a recent study concludes. Johns Hopkins Kimmel Cancer Center director William Nelson says there’s an even more accurate method on the horizon.
Nelson: Will RNA sequencing provide a better avenue in some way for cancer screening or for disease monitoring? My hunch is that it may not be the optimal one for cancer monitoring. What appears to be doing that in better sense now are the so-called ultra high sensitive sequencing approaches. This is an idea where you get your cancer you get its DNA sequenced in its entirety and then you build a test for an individual that has many, many mutations these are very, very sensitive. :31
Nelson says studies utilizing this approach are underway for both colorectal and breast cancers, and he suspects validation in the near future. At Johns Hopkins, I’m Elizabeth Tracey.
Nelson: Will RNA sequencing provide a better avenue in some way for cancer screening or for disease monitoring? My hunch is that it may not be the optimal one for cancer monitoring. What appears to be doing that in better sense now are the so-called ultra high sensitive sequencing approaches. This is an idea where you get your cancer you get its DNA sequenced in its entirety and then you build a test for an individual that has many, many mutations these are very, very sensitive. :31
Nelson says studies utilizing this approach are underway for both colorectal and breast cancers, and he suspects validation in the near future. At Johns Hopkins, I’m Elizabeth Tracey.
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