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Hype-othesis

Author: Hype-othesis

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College friends Cillian and Amandine, who are currently studying immunology and genetics, discuss their favourite things in science, especially biology. Join us as we tell each other about some of the interesting things we’ve learned over the years, ask (mostly) reasonable questions and when we don’t know the answers we make our best guess and… hype-othesise! Instagram: @hypeothesispod | Email: hypeothesispod@gmail.com
17 Episodes
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This week we talk about cancer: what it is, how it evolves and how we can treat it. 
In this episode Amandine talks about how gene expression is controlled at many different levels in the cell.  Gene expression is highly regulated in cells to make sure genes are only expressed when and where they're needed to keep everything running smoothly... and so that you don't grow a brain in your leg 
Adjuvants: what are they and why is Cillian obsessed with them? They are particularly important in cancer vaccines and vaccines against some of the more complex pathogens, but that’s just the beginning! 
How to Science

How to Science

2021-02-0858:19

This week we talk about some of the techniques used in cell biology! Ever wonder how that discovery was made? Maybe now you'll know (or maybe not lol).  We talk about mutagenesis studies, microscopy, the famous PCR, flow cytometry and ELISA! 
This week we talk about co-evolution including the evolution of the immune system, pollination and bats (which are even cooler than you think 🦇)
We're back! In this episode we cover one of our all-time favourite topics... EVOLUTION!!!   We talk about natural selection, speciation and the evolution of bright colours as poison signals!  We love this topic so much that we didn't get to cover everything we wanted to say, so stay tuned for Evolution Part 2!
You're just a vessel

You're just a vessel

2020-12-1659:10

This episode is all about the microbiome. That means we're talkin' poop pills, the immune system in your gut and if your microbiome might be able to affect your mood...
Life goes on

Life goes on

2020-12-0951:39

In this episode, we talk about where life came from and how it (might've) started.  From the building blocks to full-on eukaryotes! How life evolved in the sea, plants conquered the land and how energy might explain the origins of more complex lifeforms (like Manny the mammoth). 
In this episode, we talk about some of our favourite stories of scientific discoveries. From prion disease to the surprising role of the immune system in fat!Kuru documentary (that Amandine mentioned): 'Kuru: The Science and the Sorcery'Guardian article: https://www.theguardian.com/science/2009/feb/25/carleton-gajdusek-obituary
Smallpox who?

Smallpox who?

2020-11-3059:48

Tackling disease is one of the core goals of biological research and we've done a pretty good job so far. Smallpox who? However, the fight rages on. How are vaccines, antibiotics and monoclonal antibodies being used to tackle disease, and where do we go from here?(Was first broadcasted live on TrinityFM)
Animals can do some pretty funky things sometimes, but how do they learn to do these things? In this episode we're talking about how different animals learn, what they learn and maybe even why they learn. (Was first broadcasted live on TrinityFM)
You got cloned!

You got cloned!

2020-11-3058:12

Genitically modified organisms (GMOs), friend or foe? In the media, GMOs are often made out to be the bad guys, is there any truth to this? How are things genetically modified in the first place? Sit down, grab a bowl of golden rice, and let's get started!(Was first broadcasted live on TrinityFM)
What determines your sex? Why is the 'Y' chromosome so small? Does your sex make you better at fighting diseases? These are some of the questions we discussed in our very first episode. (This episode was first aired live on TrinityFM)
Sickness in the brain

Sickness in the brain

2021-06-2650:03

We’re back! This episode is about sickness in the brain. We talk about why you want to stay in bed when you’re sick, how inflammation can be involved in mood disorders and how Covid-19 can affect your brain. 
In this episode, we're joined by a very special guest, Miruna! We talk about glycosylation (adding sugars to molecules) and its role in the microbiome, immunology and cancer. 
This week we talk about the circadian rhythm, our natural body clock! We discuss how it works, the impact it has on our mood and health and why we should spend more time in the sun to keep our clocks in time!(Apologies for the clicking noise that's sometimes present when Cillian speaks in this episode!). 
The Philosophy of Science

The Philosophy of Science

2021-03-0801:05:15

Lace up those Docs, plop a big beret on your head and don a toga because we're talking about philosophy (of science to be exact). In this episode we talk about the philosophy of science with our very first guest Matthew!!! What is science? Can we trust scientific theories? Is science a social construct?
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