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© 2024 Nick Jikomes
Description
Whether food, drugs or ideas, what you consume influences who you become. Learn directly from the best scientists & thinkers alive today about how your mind-body reacts to what you feed it.
The weekly M&M podcast features conversations with the most interesting scientists, thinkers, and technology entrepreneurs alive today.
Not medical advice.
At M&M, we are interested in trying to figure out how things work, not affirming our existing beliefs. We prefer consulting primary rather than secondary sources and independent rather than institutional voices. If we encounter uncomfortable truths or the evidence suggests unfashionable ideas may be valid, so be it.
As the host, my aim is to help you better understand how the body & mind work by curating & synthesizing information in a way that yields science-based insights that you can choose to use or disregard in your own life. Taking ownership of your health starts with taking ownership of your information diet.
I am motivated to connect the dots and distill general principles from what I learn, preferring to ask questions and play devil’s advocate to debating or incessantly pushing my own viewpoint.
My beliefs:
- Taking ownership of your health starts with taking ownership of your information diet.
- All knowledge is provisional and we must work hard to prevent ourselves from becoming attached to our favorite ideas & preferred conclusions.
- Wisdom comes from an iterative, trial-and-error process of learning and unlearning. Letting go of pre-conceived notions can be painful, but pain is information.
Sometimes modern discoveries teach us we must unlearn received wisdom. Other times, modern information overload & historical chauvinism cause us to forget ancient wisdom which stills applies. The framework for learning that I embody is inspired by three Ancient Greek maxims inscribed in the Temple of Apollo at Delphi:
- “Γνῶθι σεαυτόν” (Know thyself)
- “Μηδὲν ἄγαν” (Nothing in excess)
- “Ἐγγύα πάρα δ Ἄτα” (Certainty brings insanity)
156 Episodes
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About the guest: Eske Willerslev, PhD is an evolutionary biologist and Professor of evolution at both the University of Copenhagen and University of Cambridge.Episode summary: Nick and Dr. Willerslev discuss: human evolution out of Africa; the origins of modern Europeans; hunter gatherers, early farmers, and pastoralists; genetics of human disease risk; evolution of diet & metabolism; evolution of light skin color; and more.*This content is never meant to serve as medical advice.Support the Show.All episodes (audio & video), show notes, transcripts, and more at the M&M Substack Try Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase.Try SiPhox Health—Affordable, at-home bloodwork w/ a comprehensive set of key health marker. Use code TRIKOMES for a 10% discount.Try the Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for $50 off.Learn all the ways you can support my efforts
1About the guest: Georgia Ede, MD is a psychiatrist and author of, "Change Your Diet, Change Your Mind: A Powerful Plan to Improve Mood, Overcome Anxiety, And Protect Memory for a Lifetime of Optimal Mental Health."Episode summary: Nick and Dr. Ede discuss: glucose vs. ketones for brain energy; metabolic health & insulin resistance; animal vs. plant-based foods; nutrients, anti-nutrients & plant toxins; ketogenic, carnivore & plant-based diets; carbohydrates & processed foods; treating bipolar disorder, schizophrenia & psychiatric illness with diet; and more.*This content is never meant to serve as medical advice.Support the showAll episodes (audio & video), show notes, transcripts, and more at the M&M Substack Try Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase.Try SiPhox Health—Affordable, at-home bloodwork w/ a comprehensive set of key health marker. Use code TRIKOMES for a 10% discount.Try the Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for $50 off.Learn all the ways you can support my efforts
About the guest: Ryan Vandrey, PhD is a Professor of Psychiatry & Behavioral Sciences at Johns Hopkins University, where his lab studies the behavioral pharmacology of cannabis (marijuana), nicotine/tobacco, and other substances.Episode summary: Nick and Dr. Vandrey discuss: marijuana; cannabinoids like THC; terpenes like limonene, myrcene, and pinene; the entourage effect; anxiety and other side effects of cannabis consumption; and more.*This content is never meant to serve as medical advice.Support the Show.All episodes (audio & video), show notes, transcripts, and more at the M&M Substack Try Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase.Try SiPhox Health—Affordable, at-home bloodwork w/ a comprehensive set of key health marker. Use code TRIKOMES for a 10% discount.Try the Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for $50 off.Learn all the ways you can support my efforts
About the guest: Matt Kaeberlein, PhD is a Professor of at the University of Washington and CEO of OptiSpan. His research focuses on the biology of aging and longevity.Episode summary: Nick and Dr. Kaeberlein discuss: the biology of aging; mTOR, FGF1, growth & metabolism; sirtuins, NAD & NMN; longevity drugs like metformin & rapamycin; facts & myths about longevity molecules like resveratrol & taurine; controversies in aging research related to prominent Harvard researcher David Sinclair; epigenetic clocks; healthspan & lifespan; and more.*This content is never meant to serve as medical advice.Support the Show.All episodes (audio & video), show notes, transcripts, and more at the M&M Substack Try Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase.Try SiPhox Health—Affordable, at-home bloodwork w/ a comprehensive set of key health marker. Use code TRIKOMES for a 10% discount.Try the Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for $50 off.Learn all the ways you can support my efforts
About the guest: Mark Bear, PhD is a Professor of Neuroscience at MIT, where his lab studies the visual system, neuroplasticity, and the pathophysiology of amblyopia and visual impairments.Episode summary: Nick and Dr. Bear discuss: the visual system in the brain, from the retina to visual cortex; critical periods of brain development; mechanisms of neuroplasticity; metaplasticity; amblyopia and visual impairments; ketamine & psychedelics; and more.*This content is never meant to serve as medical advice.Support the Show.All episodes (audio & video), show notes, transcripts, and more at the M&M Substack Try Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase.Try SiPhox Health—Affordable, at-home bloodwork w/ a comprehensive set of key health marker. Use code TRIKOMES for a 10% discount.Try the Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for $50 off.Learn all the ways you can support my efforts
About the guest: Kevin McKernan is the Chief Science Officer at Medicinal genomics and has been working the the biotechnology sector and conducting genomics research going back to his involvement in the Human Genome Project.Episode summary: Nick and Kevin discuss: basics of DNA and RNA biology; mRNA vaccines and how they work compared to traditional vaccines; the mRNA vaccine manufacturing process; DNA contamination in the Pfizer and Modern mRNA vaccines for COVID; the SARS-CoV-2 spike protein; vaccine side effects; ivermectin and hydroxychloroquine; and more.*This content is never meant to serve as medical advice.Support the Show.All episodes (audio & video), show notes, transcripts, and more at the M&M Substack Try Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase.Try SiPhox Health—Affordable, at-home bloodwork w/ a comprehensive set of key health marker. Use code TRIKOMES for a 10% discount.Try the Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for $50 off.Learn all the ways you can support my efforts
About the guest: Luc van Loon, PhD is a Professor of Physiology of Exercise and Nutrition and Head of the M3-research group at the Department of Human Biology at Maastricht University. His lab focuses on the skeletal muscle adaptive response to physical (in)activity, the impact of nutrition on metabolism, and related topics.Episode summary: Nick and Dr. van Loon discuss: amino acid biology; branched chain amino acids like leucine; atypical amino acids like taurine; muscle growth & muscle biology; dietary protein and plant vs. animal protein sources; resistance training and anabolic growth; the limits of dietary protein on muscle growth; and more.*This content is never meant to serve as medical advice.Support the Show.All episodes (audio & video), show notes, transcripts, and more at the M&M Substack Try Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase.Try SiPhox Health—Affordable, at-home bloodwork w/ a comprehensive set of key health marker. Use code TRIKOMES for a 10% discount.Try the Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for $50 off.Learn all the ways you can support my efforts
About the guest: Tommaso Di Ianni, PhD is an Assistant Professor in the Departments of Psychiatry & Behavioral Sciences and Radiology & Biomedical Imaging at the University of California, San Francisco. His lab uses ultrasound technology and deep learning to study the brain.Episode summary: Nick and Dr. Di Ianni discuss: the current state of scientific understanding of ketamine; S-ketamine vs. R-ketamine isomers; the antidepressant effects of ketamine; ketamine's known mechanisms of action; sex-dependent effects of ketamine action in the brain; involvement of the opioid system in ketamine's effects; addiction; and more.*This content is never meant to serve as medical advice.Support the showAll episodes (audio & video), show notes, transcripts, and more at the M&M Substack Try Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase.Try SiPhox Health—Affordable, at-home bloodwork w/ a comprehensive set of key health marker. Use code TRIKOMES for a 10% discount.Try the Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for $50 off.Learn all the ways you can support my efforts
About the guest: Scott Zimmerman is an optical engineer and photobiology expertEpisode summary: Nick and Scott talk about: how light interacts with the body and affects our cells; melatonin as an antioxidant; how red & near-infrared light affect mitochondria; sunlight, fire light, and artificial light; incandescent light bulbs vs. LEDs; negative health effects of artificial light; sunscreen & makeup; red & near-infrared light therapy; the optical properties of the human body; and more.*This content is never meant to serve as medical advice.Support the Show.All episodes (audio & video), show notes, transcripts, and more at the M&M Substack Try Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase.Try SiPhox Health—Affordable, at-home bloodwork w/ a comprehensive set of key health marker. Use code TRIKOMES for a 10% discount.Try the Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for $50 off.Learn all the ways you can support my efforts
About the Guest: Bruce Blumberg, PhD is a Professor of Cell & Developmental Biology at UC-Irvine. HIs lab studies epigenetics, gene x environment interactions, hormones & endocrine disruptors, obesogens & environmental toxins, and more.Episode Summary: Nick and Dr. Blumberg discuss: Embryonic development; hormones and hormone receptors; estrogen & xenoestrogens; environmental toxins, obesogens, pesticides & contaminants; environmental causes of obesity; microplastics; how to avoid toxins in food & drinking water; and more.*This content is never meant to serve as medical advice.Support the Show.All episodes (audio & video), show notes, transcripts, and more at the M&M Substack Try Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase.Try SiPhox Health—Affordable, at-home bloodwork w/ a comprehensive set of key health marker. Use code TRIKOMES for a 10% discount.Try the Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for $50 off.Learn all the ways you can support my efforts
About the Guest: Clare Bryant, DVM is a Professor of Innate Immunity at Cambridge University. Her lab studies the innate immune system, pathogen detection, inflammation, and chronic disease.Episode Summary: Nick and Dr. Bryant discuss: mechanisms of inflammation; inflammasomes & fatty acids; infection & disease; innate vs. adaptive immunity; chronic inflammation; allergies & allergens; the evolution of the immune system; anti-inflammatory effects of fasting; and more.*This content is never meant to serve as medical advice.Support the Show.All episodes (audio & video), show notes, transcripts, and more at the M&M Substack Try Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase.Try SiPhox Health—Affordable, at-home bloodwork w/ a comprehensive set of key health marker. Use code TRIKOMES for a 10% discount.Try the Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for $50 off.Learn all the ways you can support my efforts
Dr. Guillaume (Will) de Lartigue is a neuroscientist at the Monell Chemical Senses Center. His lab studies the neurobiology of eating, including how the vagus nerve senses internal stimuli in the gut. They discuss: gut-brain communication; the vagus nerve; gut hormones like leptin & GLP-1; weight loss drugs like Ozempic; glucose vs. fructose vs. non-caloric sweeteners; how the vagus nerve connects the gut to the dopamine reward system in the brain; the sensation of fats and sugars in the gut; food addiction & obesity; and more.More M&M content about diet & metabolism: https://substack.com/search/diet%20metabolism?focusedPublicationId=513528&searching=focused_postsSupport the Show.All episodes (audio & video), show notes, transcripts, and more at the M&M Substack Try Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase.Try SiPhox Health—Affordable, at-home bloodwork w/ a comprehensive set of key health marker. Use code TRIKOMES for a 10% discount.Try the Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for $50 off.Learn all the ways you can support my efforts
Dr. Nicolas Glynos received his PhD in Molecular & Integrative Physiology from the University of Michigan, where he studied the psychedelic drug DMT in the mammalian brain. They discuss: the history of DMT research; the use of DMT in ayahuasca; whether DMT is found endogenously in animals; why plants produce DMT; pineal gland, DMT & melatonin; the latest research looking at the presence and effects of DMT in the brain; and more.More M&M content about psychedelics: https://substack.com/search/psychedelics?focusedPublicationId=513528&searching=focused_posts#psychedelics #DMT #science #neuroscience #podcast #serotoninSupport the Show.All episodes (audio & video), show notes, transcripts, and more at the M&M Substack Try Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase.Try SiPhox Health—Affordable, at-home bloodwork w/ a comprehensive set of key health marker. Use code TRIKOMES for a 10% discount.Try the Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for $50 off.Learn all the ways you can support my efforts
About the Guest: Terrence Deacon, PhD is a Professor in the department of Anthropology at UC-Berkeley. He has written many papers and multiple books about the evolution of human language, origins of consciousness, and related topics.Episode Summary: Nick and Dr. Deacon discuss various aspects of biological evolution, from natural vs. sexual selection to gene duplication and the consequences of domestication; the domestication of dogs and songbirds; human vs. non-human forms of vocal communication; ritual behavior & the origins symbolic cognition; artificial intelligence & large language models (LLMs); and more.*This content is never meant to serve as medical advice.#language #consciousness #evolution #biology #AI #artificialintelligence #cognition #anthropologySupport the showAll episodes (audio & video), show notes, transcripts, and more at the M&M Substack Try Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase.Try SiPhox Health—Affordable, at-home bloodwork w/ a comprehensive set of key health marker. Use code TRIKOMES for a 10% discount.Try the Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for $50 off.Learn all the ways you can support my efforts
About the guest: Robert Lustig, MD is a physician-researcher and expert of metabolic health. He is Professor emeritus of Pediatrics, Division of Endocrinology at the University of California, San Francisco (UCSF), specializing in neuroendocrinology with an emphasis on the regulation of energy balance by the central nervous system. His research and clinical practice has focused on childhood obesity and diabetes.Episode summary: Nick and Dr. Lustig discuss the true causes of obesity and metabolic discussion; how the in utero environment during pregnancy leads to multigenerational effects on health; different forms of sugar like fructose vs. glucose; different dietary fats like omega-6 and omega-3 PUFAs, and saturated fat; oxidative stress & mitochondria biology; how temperature, altitude & oxygen affect obesity; processed foods and how industry influences public perception; body positivity & public education; insulin, diabetes & fatty liver disease; statins & cardiovascular health; and more.*This content is never meant to serve as medical advice.Support the Show.All episodes (audio & video), show notes, transcripts, and more at the M&M Substack Try Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase.Try SiPhox Health—Affordable, at-home bloodwork w/ a comprehensive set of key health marker. Use code TRIKOMES for a 10% discount.Try the Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for $50 off.Learn all the ways you can support my efforts
Mark Mattson, PhD is a semi-retired neuroscientist at Johns Hopkins who ran a research lab at the NIH for many years. He wrote the book, "The Intermittent Fasting Revolution." Nick and Dr. Mattson discussed: intermittent fasting & diet; ketosis & metabolic switching; aging & neurodegenerative disease; exercise, stress, and neuroplasticity; and more.Support the showAll episodes (audio & video), show notes, transcripts, and more at the M&M Substack Try Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase.Try SiPhox Health—Affordable, at-home bloodwork w/ a comprehensive set of key health marker. Use code TRIKOMES for a 10% discount.Try the Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for $50 off.Learn all the ways you can support my efforts
Sean B. Carroll, PhD is an evolutionary developmental biologist at the University of Maryland, who recently stepped down as VP of Education at the Howard Hughes Medical Institute. He is the author of many popular science books, such as "Endless Forms Most Beautiful." They discuss: developmental biology & genetics; evolutionary biology; genetics, genome size & genetic mutation; animal diversity; snake venom; human brain evolution; and more.Support the showAll episodes (audio & video), show notes, transcripts, and more at the M&M Substack Try Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase.Try SiPhox Health—Affordable, at-home bloodwork w/ a comprehensive set of key health marker. Use code TRIKOMES for a 10% discount.Try the Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for $50 off.Learn all the ways you can support my efforts
Dr. David Nichols is a retired chemist and father of Dr. Charles Nichols, a researcher studying psychedelics at Louisiana State University. They discussed: the history of psychedelics science from the 1970s to the present; DMT & 5-MeO-DMT; serotonin, inflammation, and psychedelics & anti-inflammatory drugs; psilocybin, ketamine, and other psychoactive drugs; and moreMore M&M content about psychedelic science: https://substack.com/search/psychedelics?focusedPublicationId=513528&searching=focused_postsSupport the Show.All episodes (audio & video), show notes, transcripts, and more at the M&M Substack Try Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase.Try SiPhox Health—Affordable, at-home bloodwork w/ a comprehensive set of key health marker. Use code TRIKOMES for a 10% discount.Try the Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for $50 off.Learn all the ways you can support my efforts
Dr. Chris Knobbe is a physician, diet & nutrition researchers, and author of, "The Ancestral Diet Revolution." He discusses: seed oils & their health consequences; different types of seed oils (soybean, corn, sunflower, etc.); omega-6 fats like linoleic acid; fatty acid metabolism and oxidation; obesity, diabetes & metabolic health; processed foods vs. whole foods; mitochondria & oxidative stress; and more.Click here for more M&M content about diet & metabolism: https://substack.com/search/diet%20metabolism?focusedPublicationId=513528&searching=focused_postsSupport the Show.All episodes (audio & video), show notes, transcripts, and more at the M&M Substack Try Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase.Try SiPhox Health—Affordable, at-home bloodwork w/ a comprehensive set of key health marker. Use code TRIKOMES for a 10% discount.Try the Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for $50 off.Learn all the ways you can support my efforts
Dr. Orrin Devinsky is a neurologist and Professor at the New York University School of Medicine. They discuss: dietary consumption trends in the US; processed vs. whole foods; vegetable oils & polyunsaturated fats; relationship between saturated fat, dietary cholesterol & heart disease; history of medicine in the US; obesity & diabetes; sugars, fructose, and metabolic health; ketogenic diet & ketosis; whether or not we can trust our public health institutions; and more.More M&M content on diet & metabolism: https://substack.com/search/diet%20metabolism?focusedPublicationId=513528&searching=focused_postsSupport the Show.All episodes (audio & video), show notes, transcripts, and more at the M&M Substack Try Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase.Try SiPhox Health—Affordable, at-home bloodwork w/ a comprehensive set of key health marker. Use code TRIKOMES for a 10% discount.Try the Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for $50 off.Learn all the ways you can support my efforts
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