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The Big Experiment

Author: Mark Davison

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Ever wondered how technology start-ups, well,  start-up? For most founder entrepreneurs, it is the biggest experiment they'll ever run. Like most experiments, the result isn't known beforehand and it often doesn't work first time. On a bigger scale, how do big tech companies turn innovative science into profit?

Mark Davison interviews founder scientists, executives, investors, communicators, and others in the technology start-up and corporate science ecosystems. 

Learn how great ideas turned into thriving businesses (or not) from those who made it happen (or didn't).  Get business tips, lessons learned, and life lessons straight from the people who know. 

Inspiring, disastrous, funny: hear what life in a science-driven company is really like.

Straight-talking, no nonsense, but conversational style.  All technical content is explained for the non-specialist - you don't need a PhD or fluency in jargon and technobabble. 

8 Episodes
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Would you have the guts to pitch directly to the customer to sell your idea?You need to be prepared to hear no a lot, and learn from the experience to adapt for the next time, to get the yes you need.This was the reality faced by my guest in this episode, Ruchi Sharma, CEO & Founder of Stemnovate Limited. She used that customer-first approach and eventually got the funding needed to start her company that focuses on stem cell research.Ruchi’s work at Stemonovate creates a unique platform ...
It is a guilty secret that the pharma and biotech industry has a big carbon footprint. Single-use plastics are a huge problem. Sensitive experiments need clean, sterile labware. This has often meant using virgin plastic with little or no recycling or reuse. Innovative approaches are needed to reduce plastic consumption in the lab.How bad is bad? On average, cell biologists produce several kg of plastic waste, each, per day. These include pipettes, plastic trays for cell growth, various ...
Imagine being able to internalise the pharmaceutical factory into the human.You could avoid the contamination risks and need for purification in biologic production.In this episode I am joined by Dr James Dooley who is doing just this with his work at Aila Biotech. James and his team developed technology to drive the production of immune-regulating biologics at the exact site of disease. Through precise spatial and temporal control over biologic expression, Aila Biotech can prevent neuroinfla...
The global population is getting older and with that comes more disease.What if we could delay ageing as a way of treating those diseases?My guest in this episode is Janette Thomas, CEO of Five Alarm Bio Ltd., a drug discovery company focusing on novel approaches to anti-aging, with broad potential therapeutic applications.She discusses the applications of this approach and where the idea came from. She also shares how they put together the information to secure investors and the art of paten...
Imagine having to climb a mountain every day just to get to school. This was the childhood of my guest George Adjabeng.George Adjabeng grew up in Ghana, the son of subsistence farmers. He excelled at chemistry in school and college, and emigrated to the USA to pursue a pharmaceutical career before turning entrepreneur. His successful company Ecodyst is now giving back to Ghana by donating equipment to universities there.In this episode George shares his experiences from that life on the farm ...
What is the future of DNA and gene synthesis?Before the covid pandemic, nucleic acids were mostly research tools. Terms like mRNA vaccines (nucleic acids as clinical agents) were relatively unknown. But since then, RNA and DNA have been thrust into the limelight for both the public and investors alike. How will the field evolve?My guest in this episode, Steve Harvey, is working at the forefront of DNA synthesis, so who better to talk us through its evolution and future.Steve is the CEO of Cam...
What are the biggest challenges facing scientific innovation?The path from science ideation to business execution is not an easy one. You will eventually need to translate great ideas into well-positioned products or services, and bring investment into the business from what can be a complex ecosystem of stakeholders.Knowing how to overcome these challenges is key to any innovation’s success.In this episode I am joined by Dr Darrin Disley OBE. Darrin is a seasoned veteran of UK life sciences....
Welcome to The Big Experiment, where we explore the scientific business world, and find out how great ideas turn into great companies.I'm Mark Davison CEO of Grant Instruments, a scientific insurance (instruments) company based in Cambridge, UK. But I'm also a veteran of pharmaceutical and biotech roles from drug discovery, right through to medicine supply chains.Amazing science impacts our lives every day, but lab breakthroughs are just the first stage in a very long journey, we're going to ...
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