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Authentic Biochemistry

Author: Dr Daniel J. Guerra

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You have wisely landed upon Authentic Biochemistry, with Dr. Daniel J Guerra, where published biochemical, physiological, genetic and immunological research along with biomedical and pharmaceutical science are interrogated.
1077 Episodes
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Professor Guerra begins an arc of lectures on the molecular events that describe the covalent modification and temporal variation of gene expression collectively called epigenetics.
T Lymphocyte communication with antigen presenting innate immune cells coupled with B cell activation may be regulated by a glycoprotein that links to discrete glycosylation patterns on membrane polypeptide domains
In this Authentic Biochemistry episode Dr Guerra unfolds the complex transcription factor and membrane & nuclear- receptor repertoire associated cytokine and chemokine axis activating and maintaining Treg cell differentiation to mediate the Th pro- inflammatory response
This is the first part of a diaeventontological framing of lipid peroxidative mechanisms for CNS neurodegeneration. Dr Guerra describes recent published research  (JLR 2018 .59:312pp.) and develops some of the key elements of the ferroptosis programmed cell death mechanism leading to  oligodendrocyte and neuronal degeneration that will participate in a grander understanding of injury-induced  and idiotypic age-associated disease in the CNS. 25 March 2019.
In this podcast, Dr Daniel Guerra of Authentic Biochemistry and VerEvMed endeavours to examine the  bioenergetic and pro-inflammatory prodromal  patho-biochemistry of age-onset Alzheimer's Disease using his diaeventontological toolkit.
Dr. Daniel J.  Guerra introduces his paradigmatic shift for understanding biochemical phenomena as prolegomena to understanding Alzheimer's Disease.
Dr Daniel Guerra of Authentic Biochemistry in his initial podcast introducing the show and starting off with initial content on current  Alzheimer's Disease research
ReferencesPLOS One 2014ovember25, https://doi.org/10.1371/journal.pone.0113939Int J Mol Sci. 2019 Mar; 20(5): 1223.Front Endocrinol (Lausanne). 2023 Feb 7;14:1085041Biomolecules.2021 Dec31;12(1):56. Lake, G. 1972. From The Beginning ELPhttps://music.youtube.com/watch?v=hsJ9YXHqnr8&si=jOAgixfiDxqknPVS
ReferencesGuerra, DJ.2025. Unpublished LecturesHepatology.2023 Apr 17;77(5):1654–1669Comprehensive Gut Microbiota2022, Pages 201-219Dylan, B. 1964. My Back Pages. Byrdshttps://music.youtube.com/watch?v=OADlrLHfYW4&si=Q63xZIE_33GXVYv4
ReferencesMol Immunol. 2017 Apr 1;87:1–11Guerra, DJ 2025 Unpublished LecturesHayward/Pinder/Lodge/Thomas. 1967. Days of Future Passed. Moody Blues.https://music.youtube.com/playlist?list=OLAK5uy_l2x8IxcSnnBm21QUI3aKwu7Sz8thfM-1w&si=9tsIhVrSdLrMn7vG
ReferencesGuerra, DJ.2025 Unpublished LecturesHepatology.2023 Feb 9;78(3):878–895.Mozart, WA. Mass in C Minor, K, 427https://music.youtube.com/watch?v=Ez0kqVShFEs&si=D1MUVoXZIbPxRyM4
ReferencesHepatology.2023 Feb 9;78(3):878–895.Mozart, WA. 1791. Ave Verum Corpus. K618https://music.youtube.com/watch?v=Z-xMjO0d-pc&si=g1TpOohQQt9forf0Murray, J. 1874 Jolly Old St Nicholas. Instrumentalhttps://music.youtube.com/watch?v=eTHdEA5zh2Q&si=0v0ADs7LhtIu7zqd
ReferencesPharmacological Reviews.2011.NOV.64(1):166-87Hepatology.2023 Feb 9;78(3):878–895.Sci Rep. 2015 Sep 30;5:14692Bach, JS. 1734. Christmas Oratories BV 248.https://music.youtube.com/watch?v=98UjjwzJBFE&si=kd45twdzgpXtJuWL
ReferencesJCI Insight .2023. May 22;8(10):e164921.J Diabetes Investig . 2024 Mar;15(3):282-284Mozart WA. 1788. Divertimento Trio in E flat Major. K 563https://music.youtube.com/watch?v=E8c83bpOVXo&si=no6hE0__w7tx5lVH
ReferencesJ Diabetes Investig.2019 Nov; 10(6): 1430–1437J Diabetes Investig. 2010 Apr 22;1(1-2):8–23J Diabetes Investig. 2016 Mar 14;7(Suppl 1):20–26EMBO Rep(2025)26: 5154 - 5171Davies, D.1970 Strangers. Kinkshttps://music.youtube.com/watch?v=p9TD5qn3fm4&si=csVw0acg0WfDyEbiJoel, B. 1977 The Strangerhttps://music.youtube.com/watch?v=X3kpaSJtaDE&si=ljQxauyI721yFs8qMorrison/ Krieger/Densmore 1967. Strange Days lphttps://music.youtube.com/playlist?list=OLAK5uy_nQKdoZqyfOqKrkHKvBqOYBm4m1YpWyKY4&si=KkLFoDVXGhfoV05s
ReferencesJ Neurophysiol. 1993 Aug;70(2):742–757.J Clin Immunol. 2025 Oct 1;45(1):141. Front Immunol. 2025 Sep 4;16:1660161.Guerra, DJ.2025.Unpublished LecturesJ Physiol. 2016 May 29;594(20):5791–5815Bach, JS 1717- 1723. Violin Concerti E, D A and Ghttps://music.youtube.com/playlist?list=OLAK5uy_lmUKX_Xp0OkaA5DCja6iviqbI7z28pW68&si=6rqmiT-6Ng64Tb7M
ReferencesExp Mol Med. 2018 Oct 10;50(10):133.Cancer Biomark. 2014 Jan 1;14(1):63-81.Blood. 1979 Jul;54(1):30-4HLA. 2016 Dec;88(6):275-286Hunter/Garcia. 1970. Dire Wolf. Grateful Dead Workingman's Dead lphttps://music.youtube.com/watch?v=VWY4hyIlsqQ&si=JTn9U0nG5UlGNT02Mozart, WA. 1778. Flute Concerto 1. G major K,313.https://music.youtube.com/watch?v=1syDCEn_XOw&si=gf0puAPtK-ezqsJn
ReferencesWorld J Gastroenterol. 2013 Nov 14; 19(42): 7258–7266.Guerra. DJ 2025. Unpublished LecturesExp Mol Med. 2018 Oct 10;50(10):133.Petty, and Lynne 1989. I Wont Back Downhttps://music.youtube.com/watch?v=3efKaFVBcMU&si=8Q4ZlOvRE7FlGpeVJagger/Richards. 1964. Jumpin' Jack Flash. Rolling Stoneshttps://music.youtube.com/watch?v=KXUJMaYzh6U&si=xhRy7yetsYUHr-oyBruce and Brown, 1968. White Room. Creamhttps://music.youtube.com/watch?v=xGxhECBbw08&si=9qfog8nk0Kn9pKg2
ReferencesGuerra, DJ. 2025 Unpublished Lectures Accounts of Chemical Research2025 FEB Vol 58/Issue 5:714-731UBMB Life, 2011. 63(3): 175–182, MarchTelemann, GP. 1715. Various Career Sonatashttps://music.youtube.com/watch?v=C7lV9c0-C3k&si=qVZmMWNmbKliH_JDWilson et al. 1966 Pet Sounds LP Beach Boys.https://music.youtube.com/playlist?list=OLAK5uy_kSxA3IV3xpP1jCo4iNFKPLcaA8trAJGf0&si=6efnAJJyGdOrhg_P
ReferencesGuerra, DJ. 2025. Unpublished lecturesEuropean Journal of Immunology1996v. 26, Issue 8. Aug pages1675-1978 Series of papers by various authorsBiochem J (2021) 478 (24): 4187–4202.Allman, G. 1972. Aint Wasting Time No More. Eat a Peach lphttps://music.youtube.com/watch?v=4uWQszeuX2A&si=MSNzbSBz9t1MteB7Miller/McCarty. 1976. Serenade. From Fly Like an Eagle LP. https://music.youtube.com/watch?v=PBnks1DTiFg&si=LKkjiX2mkmPvcXfiHendrix. J. 1971. Angelhttps://music.youtube.com/watch?v=GYZ8ofg9qKc&si=yIRyE7ABnVdtGgiDMayall, J.1970. USA Union lphttps://music.youtube.com/watch?v=weU6JgaYdqk&si=W-pFwHi2Y2MSbkJR
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Comments (1)

Robert Bristow

listening to episode one from 2019 in which Doctor Guerra was talking about insulin and Alzheimer's disease. I googled it. now 12/12/2025 some are starting to call AD type 3 diabetes. BRAVO DR. DANIEL J. GUERRA!!!! . It seems to me that diabetes screws with everything in the body. . Robert Bristow LVN.

Dec 12th
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