Arjun Khemani Podcast

My conversation with Aubrey de Grey, a biomedical gerontologist, founder of the LEV Foundation, and author of Ending Aging.Watch on YouTube or X. Listen on Apple Podcasts, Spotify, or any other podcast platform. Follow me on X for updates on future episodes.Timestamps0:00 - SENS vs. the Hallmarks of Aging2:47 - The Robust Mouse Rejuvenation experiment5:48 - Is SENS falsifiable?7:12 - CMLase and extracellular matrix damage10:28 - VEGF and extending lifespan in mice11:37 - Why longevity studies rarely get replicated13:05 - Michael Levin, bioelectricity & aging as information loss15:03 - Is partial reprogramming overhyped?17:32 - The most neglected areas of longevity research18:56 - Longevity escape velocity explained20:28 - Will people alive today live long enough?23:42 - How far are we from dramatically extending mouse lifespan?24:54 - What happens to society if we solve aging?27:20 - How longevity could reshape the global economy28:44 - Does mortality give life meaning?30:00 - Aubrey on the “pro-aging trance”31:34 - What Aubrey would do after solving aging This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit www.arjunkhemani.com

My conversation with Michael Levin, a biologist at Tufts University whose research explores bioelectricity, regeneration, morphogenesis, and how cells collectively process information to build and repair bodies.Topics we discuss are well captured by the timestamps below.Watch on YouTube or X. Listen on Apple Podcasts, Spotify, or any other podcast platform. Follow me on X for updates on future episodes.Timestamps0:00 - Causes and downstream effects of aging3:31 - Bioelectric patterns and memory in regeneration9:30 - Cracking the bioelectric code12:10 - The boredom theory of aging23:11 - The germline is ageless25:45 - Bioelectricity and epigenetic reprogramming27:15 - What experiment could falsify Mike’s ideas?29:13 - The role of aging clocks and biological age31:06 - Top-down control in biological systems39:09 - Consciousness and its implications48:25 - Changing human goals and preferences51:30 - The future of medicine This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit www.arjunkhemani.com

Karl Pfleger is the founder of agingbiotech.info and an investor in several rejuvenation startups.Topics we discuss are well captured by the timestamps below.Watch on YouTube or X. Listen on Apple Podcasts, Spotify, or any other podcast platform. Follow me on X for updates on future episodes.Timestamps0:00 - Why lifespan is the wrong metric for aging progress7:28 - Is the hallmarks of aging expanding a problem?11:36 - Structures vs. processes: the key distinction in aging targets16:14 - Why Karl favors divide-and-conquer rejuvenation over slowing aging22:07 - Whole-body replacement and organ/cell-level rejuvenation26:56 - Is partial epigenetic reprogramming the kill-shot for aging? 35:24 - CMLase and reversing crosslink damage40:57 - Can AI just solve aging automatically?46:57 - Funding misallocation and the case for more aging biotech companies/VC57:28 - Objections to eliminating aging — and why none hold up1:01:27 - Karl critiques Bryan Johnson’s “Don’t Die” This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit www.arjunkhemani.com

David D. Friedman is an anarcho-capitalist economist. He is the author of The Machinery of Freedom, Future Imperfect, and several other books. Topics we discuss are well captured by the timestamps below.Watch on YouTube or X. Listen on Apple Podcasts, Spotify, or any other podcast platform. Follow me on X for updates on future episodes.Timestamps0:00 – The economics of longevity8:05 – Epigenetic reprogramming12:37 – Overpopulation and the “ultimate resource”16:33 – Fluid vs. crystallized intelligence, aging and political power20:46 – Cryonics24:35 – AI, open source, and the surveillance state28:29 – Zcash, privacy, and cryptocurrency41:12 – Taxes, government, and money supply50:27 – A poem about tyranny and benevolence56:42 – Education and its resistance to change1:05:42 – Argentina, Milei, and planning for an uncertain future This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit www.arjunkhemani.com

Sean Bowe is a core cryptographer and engineer who played a major role in building Zcash’s technology.Dev Ojha, also a cryptographer, is the founder of Osmosis. He is now working on helping Zcash scale and go post quantum.Topics we discuss are well captured by the timestamps below.Watch on YouTube or X. Listen on Apple Podcasts, Spotify, or any other podcast platform. Follow me on X for updates on future episodes.Timestamps0:00 - Why Dev’s working on Zcash12:24 - AI is surveillance’s ultimate weapon13:33 - Encrypted money must scale15:49 - Compliant “privacy” is an oxymoron19:25 - PIR for scaling Zcash36:35 - How Tachyon and PIR work hand in hand43:47 - Quantum recoverability47:18 - Is quantum the last cryptography problem?51:41 - Easier coinholder voting process1:03:15 - Zcash roadmap1:17:34 - What Zcash looks like at scale This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit www.arjunkhemani.com