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Tune up with Mike and Mani: Brain Science Step by Step
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Tune up with Mike and Mani: Brain Science Step by Step

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Each week Dr. Mani Pavuluri talks with host Mike Knezovich to explain brain health issues, the science behind them and treatments. Dr. Pavuluri draws on experience treating thousands of patients for bi-polar disorder, substance abuse, depression, and other brain and mental health issues.
19 Episodes
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Tune up with Mike and Mani: Brain Science and Wellness, EPISODE 2: Life Skills Brain health explained in lay terms by leading psychiatrist Dr. Mani Pavuluri EPISODE 2: Life Skills Each week, Dr. Mani Pavuluri talks with host Mike Knezovich to explain brain health issues, the science behind them, treatments–with a focus on brain and wellness. This is the second […] The post Podcast: Maintaining the Wheel of Life, part 2 first appeared on Dr. Mani Pavuluri.
Tune up with Mike and Mani: Brain Science and Wellness, EPISODE 1- Life Principles Brain health explained in lay terms by leading psychiatrist Dr. Mani Pavuluri EPISODE 1 Principles: Each week, Dr. Mani Pavuluri talks with host Mike Knezovich to explain brain health issues, the science behind them, treatments–with a focus on brain and wellness. We will do three episodes […] The post Podcast: Maintaining the Wheel of Life first appeared on Dr. Mani Pavuluri.
Podcast: Tune up with Mike and Mani: Brain Science Step by Step  In this episode, Dr. Pavuluri explains collective research that used functional MRI (fMRI) to shed light on how focusing on tasks can help kids with pediatric bipolar disorder regulate their emotional brain circuitry regions such as the amygdala. The post Focusing Attention Calms the Emotional Brain Regions first appeared on Dr. Mani Pavuluri.
Dr. Mani Pavuluri talks with host Mike Knezovich to explain brain health issues, the science behind them, and treatments. In this episode, Dr. Pavuluri explains the complexities and emotional pain of eating disorders, and how treatment offers hope to those with eating disorders–and their loved ones. The post Podcast: A Glimpse into Eating Disorders–Walk Out of Artificial Structure first appeared on Dr. Mani Pavuluri.
Podcast: Tune up with Mike and Mani: Brain Science Step by Step Brain health explained in lay terms by leading psychiatrist Dr. Mani Pavuluri Dr. Mani Pavuluri talks with host Mike Knezovich to explain brain health issues, the science behind them and treatments. In this episode, Dr. Pavuluri explains that ADHD varies in nuanced ways for each individual, and how […] The post Personalized Treatment for ADHD- Gifted or Not first appeared on Dr. Mani Pavuluri.
Brain health explained in lay terms by leading psychiatrist Dr. Mani Pavuluri Each week, Dr. Mani Pavuluri talks with host Mike Knezovich to explain brain health issues, the science behind them, and treatments. In this episode, Dr. Pavuluri has advice for parents of adult children who are struggling with mental health issues and often with associated substance abuse. We address how […] The post Guidance for Parents of Young Adults with Mental Health Problems first appeared on Dr. Mani Pavuluri.
Tune up with Mike and Mani: Brain Science Step by Step Brain health explained in lay terms by leading psychiatrist Dr. Mani Pavuluri Each week, Dr. Mani Pavuluri talks with host Mike Knezovich to explain brain health issues, the science behind them and treatments. In this episode, Dr. Pavuluri offers cautionary advice regarding young people and the use of marijuana. […] The post Podcast: Words of caution regarding cannabis first appeared on Dr. Mani Pavuluri.
Tune up with Mike and Mani: Brain Science Step by Step  Verbal Memory Dr. Pavuluri explains the role of verbal memory and visuospatial memory in learning. This is closely connected to dyslexia and related learning difficulties. The post Podcast: Verbal Memory and Learning first appeared on Dr. Mani Pavuluri.
Tune up with Mike and Mani: Brain Science Step by Step In the previous podcast, Dr. Mani Pavuluri introduced the concept of perspective taking. In this followup, Dr. Pavuluri and Mike delve further into the subject, explaining the difference between perspective taking, empathy and theory of mind, and expanding on the brain science behind perspective taking. Mike and Mani also […] The post Podcast: Perspective Taking, Part II first appeared on Dr. Mani Pavuluri.
Tune up with Mike and Mani: Brain Science Step by Step The ability to step into someone else’s shoes–to see things from their point of view–is another remarkable feature the human brain provides. In this episode, Mike and Dr. Mani Pavuluri explore how our minds enable us to take perspectives other than our own.   The post Podcast: The Brain Function behind Perspective Taking: Part 1 first appeared on Dr. Mani Pavuluri.
Tune Up with Mike and Mani: Brain Science Step by Step Brain Changes with Mindfulness You’ve likely read or heard about the wonders of mindfulness and meditation. Are they for real? Mike talks to Mani about what research has taught us on brain at work during mindfulness.
Tune up with Mike and Mani: Brain Science Step by Step Emotion Processing Mike and Dr. Pavuluri discuss brain mechanisms of emotion processing that include how emotions are captured, stored, retrieved and experienced in day to day life.
Tune up with Mike and Mani: Thinking and Feeling Good  Brain Science Step by Step: Executive Function Mike and Dr. Pavuluri discuss executive function–our ability to operate in goal-directed behavior with flexibility and adjusting action strategy with changing environmental demands.
Tune up with Mike and Mani: Thinking and Feeling Good  Brain Science Step by Step: Cognitive Flexibility Domain In this episode, we explore how the brain works to adapt to multiple changing circumstances–how to “think on our feet” and shift.
Tune up with Mike and Mani: Thinking and Feeling Good Brain Science Step by Step: Impulse Control In this episode, Dr. Pavuluri talks with Mike about the brain science behind impulses, and what goes wrong in the circuitry of someone who lacks impulse control.
Tune up with Mike and Mani: Thinking and Feeling Good In this episode, Dr. Pavuluri talks with Mike about rumination, which she terms “hamster wheel thinking.” It’s a repetitive self-critical thought process that is also known as toxic brooding.  Program note regarding discussion that begins at 12:20 and ends at  13:00: The amygdala has a strong connection with the medial prefrontal cortex […]
Tune up with Mike and Mani: Thinking and Feeling Good In this episode, Dr. Pavuluri talks with Mike about how reward circuitry and the emotion circuitry are linked in a region called the nucleus accumbens–and what happens when the circuit goes haywire. Related Post Reward and Emotion Circuits are Linked in the Brain: A Hot Mess If Things Go Wrong
Host Mike Knezovich and Dr. Mani Pavuluri introduce the start of periodic podcasts that translate science and knowledge into techniques for thinking and feeling good.
Staying Connected–Using Storytelling and Other Techniques to Maintain Communication Dr. Pavuluri talks to Mike about the real-world challenges — and solutions — to staying connected with family and friends. Related topics: Scaffolding Conversations: Verbal Comprehension and Expression Feather Dusting Difficult Communication    
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