The Human Upgrade with Dave Asprey

Fear is quietly running your life—and it’s holding you back from the purpose and success you deserve. In this episode, we revisit Dave chatting with one of the keynote speakers for the Biohacking Conference 2025, Ryan Holiday, the bestselling author of Courage Is Calling, to tackle the one thing standing between you and your potential: fear. Why should you listen? Because fear is the root cause of procrastination, self-doubt, and the endless excuses that keep you stuck. Ryan reveals why courage isn’t just about bravery—it’s about making the hard choices that align with your purpose, even when the stakes are high. Drawing on powerful examples from history and modern life, Ryan explains how fear can be transformed into a catalyst for action and why embracing discomfort is the key to unlocking true freedom. If you’ve ever felt paralyzed by uncertainty, this episode will give you the tools and perspective to take control, face your fears, and create the life you’re meant to live. Why This Episode Matters:  • You’ll discover how fear sneaks into your decisions—and how to stop it  • Learn why courage is the ultimate skill for success and fulfillment  • Get actionable advice to break through self-imposed limits  • Understand the psychology of fear and how to use it as fuel  • Hear real-life stories of people who overcame fear to achieve greatness Resources:  2025 Biohacking Conference – https://biohackingconference.com/2025 Ryan Holiday’s Website – https://ryanholiday.net Daily Stoic Website – https://dailystoic.com/ Ryan Holiday’s Book: Courage Is Calling – https://a.co/d/czEfCXC Ryan Holiday’s Instagram – https://www.instagram.com/ryanholiday Danger Coffee – https://dangercoffee.com Dave Asprey’s Website – https://daveasprey.com Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books Dave Asprey’s Linktree – https://linktr.ee/daveasprey Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com Own an Upgrade Labs – https://ownanupgradelabs.com Upgrade Labs – https://upgradelabs.com 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement – https://40yearsofzen.com Sponsors -Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order. -Pendulum | Go to https://pendulumlife.com/ and use code Asprey20 for your first month of GLP-1 or any Pendulum formula. Timestamps:  • 00:00 – Intro  • 00:44 – Discussing Ryan Holiday’s Work  • 02:37 – The Concept of Courage  • 08:09 – Fear and Courage in History  • 12:41 – Stoic Philosophy and Modern Applications  • 21:50 – The Four Virtues and Their Interrelation  • 28:39 – Challenges in Admitting Mistakes  • 35:21 – Navigating Business Risks During a Pandemic  • 36:44 – The Essence of Courage in Business and Life  • 37:03 – Reed Hastings and the Duality of Courage  • 40:06 – Moral Courage: Lessons from History  • 43:35 – The Debate on Mandates and Personal Freedom  • 45:22 – Balancing Public Health and Individual Rights  • 58:29 – The Role of Responsibility in Society  • 01:09:01 – The Importance of Intellectual Courage  • 01:12:04 – Reaching Audiences in a Noisy World  • 01:13:27 – Final Thoughts and Encouragement See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Today we are bringing back one of our all-time favorite episodes with James Altucher. Dave sits down with James, an entrepreneur, bestselling author, and master experimenter, to uncover why the 10,000-hour rule might just be holding you back. Instead of grinding your way to expertise, James reveals his 10,000 Experiment Rule—a game-changing approach to mastering any skill faster than you thought possible. From comedy stages to boardrooms, James has redefined success through relentless experimentation and bold pivots. In this electrifying conversation, he exposes the toxic allure of “failure porn” and why glorifying failure might be sabotaging your growth. You’ll learn why skipping the line isn’t just possible—it’s essential for thriving in a world obsessed with rigid rules. This episode dives deep into the power of curiosity, the art of experimentation, and the strategies James uses to crush the myth of conventional wisdom. Whether you’re stuck in a career rut, looking to start something new, or just want to optimize your life, James delivers unfiltered insights to help you rewrite the rules. What You’ll Learn: • Why the 10,000-hour rule is outdated—and what actually works • How “failure porn” is dragging you down (and how to escape it) • The 10,000 Experiment Rule that accelerates skill mastery • Bold strategies to break through limits and skip the line in any industry • Why curiosity is the ultimate superpower for growth and success • Practical steps to monetize your passion and build a life you love Resources:  2025 Biohacking Conference – https://biohackingconference.com/2025 James Altucher’s Website – https://www.jamesaltucher.com The James Altucher Show Podcast – https://podcasts.apple.com/us/podcast/the-james-altucher-show/id794030859 Danger Coffee – https://dangercoffee.com Dave Asprey’s Website – https://daveasprey.com Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books Dave Asprey’s Linktree – https://linktr.ee/daveasprey Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com Own an Upgrade Labs – https://ownanupgradelabs.com Upgrade Labs – https://upgradelabs.com 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement – https://40yearsofzen.com Sponsors -Calroy | Head to https://calroy.com/dave for an exclusive discount. -Viome | Go to https://viome.com/dave to save $110 on the Full Body Intelligence Test.  Timestamps: 00:00 Introduction to The Human Upgrade Podcast 00:38 Meet James Altucher: Entrepreneur and Author 01:02 The Comedy Journey: From Advice to Stage 02:06 The Controversial New York Article 03:42 Facing Backlash and Public Reaction 10:46 The 10,000 Experiment Rule 15:44 Skipping the Line: Challenging Conventional Wisdom 23:35 The Importance of Loving What You Do 31:30 A Chance Encounter with Howard Schultz 32:11 The Plus Minus Equals Technique 33:26 Applying Techniques to Chess Mastery 34:43 The Importance of Curiosity 36:30 Experimenting with Comedy 38:44 The Concept of Failure Porn 40:39 The Hero’s Journey in Business 44:42 Living an Experimental Life 47:10 Frame Control in High-Stakes Situations 53:43 Advice for Parents and Kids 55:29 Conclusion and Book Promotion See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Can you use hate to make the world a better place?  Daryl Davis, a world-class jazz musician, didn’t just confront hate—he dismantled it. By sitting down with over 200 Ku Klux Klan members, he inspired them to leave their robes behind. But this isn’t just a story about racism or redemption; it’s a story about the incredible power of human connection and the lessons it holds for all of us. In this special episode, Dave explores how Daryl turned impossible conversations into transformative breakthroughs. Together, they unpack the mindset shifts, emotional intelligence, and fearless curiosity that can break down barriers of all kinds—whether they’re rooted in bias, fear, or misunderstanding. Daryl’s approach to erasing hate is so unique, so impactful, that it may just change how you view conflict, compassion, and even your own health. What You’ll Learn:  • How Daryl’s global upbringing shaped his fearless approach to conflict  • Why eliminating hate starts with understanding, not opposition  • The neuroscience of compassion and how it rewires your brain  • How forgiveness can transform your health and happiness  • A step-by-step framework for tackling impossible conversations Resources:  2025 Biohacking Conference – https://biohackingconference.com/2025 Daryl Davis's Book: Klan-destine Relationships (Go read it for free at your local library instead of buying on Amazon :)) Daryl Davis's Website – https://www.daryldavis.com Daryl Davis on Instagram – https://www.instagram.com/realdaryldavis/ Danger Coffee – https://dangercoffee.com Dave Asprey’s Website – https://daveasprey.com Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books Dave Asprey’s Linktree – https://linktr.ee/daveasprey Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com Own an Upgrade Labs – https://ownanupgradelabs.com Upgrade Labs – https://upgradelabs.com 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement – https://40yearsofzen.com Sponsors: -Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial. -Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. Timestamps:  • 00:00 A Shocking Parade Experience  • 00:38 Meeting the KKK: First Impressions  • 01:06 Introducing Daryl Davis  • 03:46 Daryl’s Unique Upbringing  • 09:52 Confronting Racism: A Lifelong Quest  • 14:16 The Power of Travel and Perspective  • 18:25 A High School Encounter with Nazis  • 21:12 Confronting the Klan Leader  • 30:57 Changing Minds: A Personal Approach  • 36:30 The Illusion of Latent Genes  • 42:08 Collecting Klan Robes: A Symbolic Victory  • 46:17 Facing the Klan: Staying Grounded  • 48:27 Challenging Beliefs: Confronting Hate  • 49:15 The Journey to Writing ‘Clandestine’  • 50:26 Introducing ‘The Klan Whisperer’  • 51:35 Reflections on Racism and History  • 57:29 The Power of Forgiveness  • 59:28 Freedom of Speech and Its Limits  • 01:02:21 Personal Stories of Racism  • 01:13:16 Cultural Understanding and Misunderstandings  • 01:25:16 The Impact of Music on Memory  • 01:29:02 Final Thoughts and Upcoming Events See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Is AI About to Replace Your Doctor? Or Save Your Life? The tools that are reshaping healthcare will redefine medicine—and your life—in ways you’ve never imagined. Will artificial intelligence and regenerative therapies like stem cells and exosomes make doctors obsolete? Or will they finally unlock the secrets to living to 180? In this episode, Dave sits down with Dr. Pradeep Albert, a leader in regenerative medicine and AI-driven imaging, to explore the intersection of technology, longevity, and healing.  Dr. Albert shares groundbreaking insights on how AI is revolutionizing medical diagnostics, replacing outdated systems, and empowering patients to take control of THEIR OWN health. He also dives deep into regenerative therapies—how PRP, exosomes, and stem cells are changing the game for injuries, inflammation, and aging.  Can AI improve patient-doctor relationships? Are doctors becoming coaches instead of gatekeepers? And most importantly, how can you leverage these tools to outlive your peers and enhance every aspect of your health? What You’ll Learn:  • Why 50% of people won’t make it past 76—and how to beat the odds  • How AI is already better than doctors at diagnosing certain conditions  • The truth about PRP, exosomes, and stem cells—and when to use each  • The three rules of longevity every person needs to know  • How your mindset and epigenetics can help you live longer and healthier Resources:  2025 Biohacking Conference – https://biohackingconference.com/2025 Dr. Pradeep Albert’s Book: Exosomes, PRP, and Stem Cells…Medicine – https://www.amazon.com/Exosomes-Stem-Cells-Musculoskeletal-Medicine/dp/B0C2S59S8K Dr. Pradeep Albert’s Book: Lifespan Decoded –https://lifespandecoded.com/ Dr Pradeep Albert’s Website – https://drpradeepalbert.com/ Danger Coffee – https://dangercoffee.com Dave Asprey’s Website – https://daveasprey.com Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books Dave Asprey’s Linktree – https://linktr.ee/daveasprey Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com Own an Upgrade Labs – https://ownanupgradelabs.com Upgrade Labs – https://upgradelabs.com 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement – https://40yearsofzen.com  Sponsors: ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order.  OneSkin | Go to https://oneskin.co/ and use code ASPREY15 for 15% off your purchase. Timestamps:  • 00:00 – Introduction to AI in Medicine  • 00:36 – The Role of AI in Longevity  • 00:51 – Meet Dr. Pradeep Alpert  • 01:11 – AI’s Impact on Healthcare  • 02:07 – Changing Role of Doctors  • 05:01 – AI in Medical Imaging  • 06:37 – Orthopedics and AI  • 09:19 – Longevity and Epigenetics  • 14:16 – The Importance of Mindset  • 29:08 – Trust in the Medical System  • 43:18 – DIY Health and Longevity  • 44:21 – The Future of Insurance and Medical Costs  • 45:45 – Advancements in Imaging Technology  • 47:26 – The Art of Physical Examination  • 50:21 – Regenerative Medicine: PRP, Exosomes, and Stem Cells  • 01:00:23 – Challenges in the US Medical System  • 01:07:54 – The Role of AI in Medicine  • 01:18:14 – Final Thoughts and Book Promotion See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Most people don’t think about their liver until it’s too late. In this episode, Dave sits down with Siggi Clavien, founder of de-liver-ance® & The Liver Clinic, to uncover the hidden superpowers of the body’s most underrated organ: the liver. This is a deep dive into why your liver is the ultimate game-changer for your energy, brain power, and longevity. Siggi reveals groundbreaking insights on reversing fatty liver disease, boosting detoxification, and harnessing the liver’s regenerative capabilities. From fighting brain fog to protecting against toxins, this episode will have you rethinking everything about how you treat your body. And yes, your liver could be the key to living a healthier, happier life. Siggi also shares the science and innovation behind de-liver-ance®, his groundbreaking herbal product designed to deliver the most powerful results in a safe, natural way. Backed by millions of dollars and years of research, de-liver-ance® is setting a new standard in liver health. Use code: DAVE at https://us.loveyourliver.com/discount/DAVE to get a discount! Dave and Siggi also explore cutting-edge strategies to supercharge your liver health using natural herbs, breakthrough science, and biohacking tools. What You’ll Learn: • Why your liver holds the key to longevity, energy, and mental clarity • How to reverse fatty liver disease—even if you’ve been told it’s irreversible • The truth about common liver-destroying habits you need to ditch now • Groundbreaking ways to protect and regenerate your liver for optimal health • The science behind de-liver-ance® and how it’s changing liver health forever • Simple, actionable strategies to boost detoxification and supercharge your body Resources:  2025 Biohacking Conference – https://biohackingconference.com/2025 de-liver-ance® – https://us.loveyourliver.com/discount/DAVE (Use code DAVE at checkout for a discount!) The Liver Clinic – https://theliverclinic.com Danger Coffee – https://dangercoffee.com Dave Asprey’s Website – https://daveasprey.com Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books Dave Asprey’s Linktree – https://linktr.ee/daveasprey Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com Own an Upgrade Labs – https://ownanupgradelabs.com Upgrade Labs – https://upgradelabs.com 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement – https://40yearsofzen.com Timestamps: • 00:00 Intro • 00:00 Introduction and Liver Basics • 01:46 Guest Introduction and Liver Health Insights • 02:16 Understanding Liver Scans and Lab Panels • 05:13 Fatty Liver Disease: Causes and Consequences • 07:07 Diet and Liver Health • 09:47 Supplements and Liver Function • 11:53 Advanced Liver Health Strategies • 14:05 Biohacking and Liver Health • 17:41 Deliverance Supplement and Its Benefits • 23:12 Liver Health and Longevity • 31:12 Biohacking: The Path to Consciousness and Longevity • 32:29 The Liver: The Body’s Regenerative Powerhouse • 34:48 Gut Microbiome and Liver Health Connection • 35:59 Lipopolysaccharides: The Hidden Toxins • 40:44 Coffee: A Surprising Ally for Liver Health • 43:16 Mold Toxins: The Silent Liver Destroyers • 48:43 Hormone Health and the Liver • 52:19 Type 2 Diabetes, Menopause, and Liver Health • 52:43 The Impact of Lifestyle on Liver Health • 54:57 The Importance of Bile and Gallbladder Health • 58:06 Genetics, Toxins, and Liver Resilience • 01:06:25 Conclusion: Investing in Liver Health for a Better Life See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Will the next nuclear bomb be AI Superintelligence? The intelligence we’re building will reshape the world in ways we never imagined—for better or worse? But more importantly, what side will humanity take? In this episode, Mo Gawdat, bestselling author of Scary Smart and former Chief Business Officer of Google X, joins Dave to tackle the profound challenges and opportunities artificial intelligence presents. This isn’t about dystopian robots or tech hype—it’s about redefining what it means to be human in the age of machines. There’s hope, don’t worry!  Mo dives into the reality of how AI is already shaping our behavior, our ethics, and even our potential for happiness. He reveals the critical need for aligning intelligence—human or artificial—with values that promote global abundance and collaboration. Dave and Mo mix data, philosophy, and bold visions, to show why our future depends on shifting from competition to cooperation. But most importantly, why all of this is going to make you a better YOU. What You’ll Learn:  • The real reason AI is reshaping human behavior—and how to take back control  • Why intelligence without ethics could lead to catastrophe  • How abundance thinking can unlock limitless possibilities for humanity  • The crucial mindset shifts leaders need to adopt before it’s too late  • Practical insights for ensuring AI supports human flourishing, not destruction Resources:  2025 Biohacking Conference – https://biohackingconference.com/2025 Mo Gawdat’s Book: Scary Smart – https://a.co/d/6DukqyW Mo Gawdat’s Book: Unstressable – https://a.co/d/hrbpY9O Follow Mo Gawdat on Instagram – https://www.instagram.com/mo_gawdat/ Danger Coffee – https://dangercoffee.com Dave Asprey’s Website – https://daveasprey.com Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books Dave Asprey’s Linktree – https://linktr.ee/daveasprey Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com Own an Upgrade Labs – https://ownanupgradelabs.com Upgrade Labs – https://upgradelabs.com 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement – https://40yearsofzen.com Sponsors: - Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order.  - fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. Timestamps:  • 00:00 The Ethical Dilemma of AI in Warfare  • 00:31 Introduction to Part Two with Mo Gawdat  • 00:58 AI and Human Happiness: A Complex Relationship  • 03:18 The Power and Responsibility of Technology  • 05:08 The Rise of AI and Its Impact on Society  • 08:31 The Future of AI: Abundance or Destruction?  • 19:53 The Role of Ethics in AI Development  • 22:39 Conclusion and Final Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Can Happiness Really Be Engineered? Mo Gawdat Says Yes—And Here’s How.  I know what you’re thinking… ANOTHER episode on happiness? Haven’t we heard it all before? This one’s different. The code is cracked, and you’re about to learn exactly how it works. Joining us today is Mo Gawdat, bestselling author of Unstressable and former Chief Business Officer of Google X. Mo sits down with Dave to deliver a practical, science-backed approach to hacking your mind and body for lasting joy. Mo dives into the raw science behind happiness and stress—revealing how your brain runs on algorithms that you can actually reprogram. Discover why dopamine might be sabotaging your joy, how to decode the four types of stress, and biohacks that can flip the script on your mental and physical resilience. He also shares the deeply personal story of how he turned unimaginable tragedy into a global mission for happiness and purpose. Mo’s insights will challenge everything you thought you knew about living a fulfilled life. What You’ll Learn:  • The happiness algorithm—and how to make it work for you  • Why dopamine addiction is robbing you of joy (and how to fix it)  • The four stress modalities and how to regain control  • Biohacks that build resilience—like cold plunges, gratitude, and micro-habits  • How small mindset shifts can create major life transformations And don’t miss Part 2, dropping in two days! Dave and Mo explore the intersection of happiness and AI, revealing how to get them both working FOR you instead of against you. Resources:  2025 Biohacking Conference – https://biohackingconference.com/2025 Mo Gawdat’s Book: Scary Smart – https://a.co/d/6DukqyW Mo Gawdat’s Book: Unstressable – https://a.co/d/hrbpY9O Follow Mo Gawdat on Instagram – https://www.instagram.com/mo_gawdat/ Danger Coffee – https://dangercoffee.com Dave Asprey’s Website – https://daveasprey.com Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books Dave Asprey’s Linktree – https://linktr.ee/daveasprey Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com Own an Upgrade Labs – https://ownanupgradelabs.com Upgrade Labs – https://upgradelabs.com 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement – https://40yearsofzen.com Sponsors: Neurohacker | Go to https://qualialife.com/dave and use code Dave for 15% off. Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial. Timestamps: 00:00 – Intro 00:31 – Introduction to The Human Upgrade 00:45 – Dave Asprey’s AI Background 01:13 – Introducing Mo Gawdat and His Work 01:51 – From Scary Smart to Unstressable 02:40 – The Journey to Happiness 13:10 – Understanding Stress and Its Mechanisms 17:26 – The Four Modalities of Stress 24:16 – Mental Stress and the Happiness Flowchart 31:34 – Sources of Stress: Trauma, Obsessions, Noise, and Nuisances 33:27 – Understanding Modern PTSD 34:09 – The Role of Obsessions and Noise 36:24 – Biohacking for Resilience 37:58 – The Power of Gratitude 40:12 – The Happiness Equation 54:37 – Dopamine vs. Serotonin 01:03:00 – The Benefits of Cold Therapy See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Does Calorie Restriction Even Work? What About the Carnivore Diet AND Fruit?  Today we are excited to have Paul Saladino join us for a masterclass on food and diets. Dr. Saladino dives into the evolution of keto and carnivore diets, cutting through trends to focus on lasting health impacts. Dr. Saladino, widely recognized as CarnivoreMD, shares how his own diet shifted to include fruit and honey alongside animal-based nutrition, and why metabolic flexibility—not rigid rules—leads to better outcomes. Together, he and Dave challenge assumptions about long-term ketosis, examine its potential downsides, and explore how to optimize diets for energy, gut health, and longevity. They also tackle controversial topics like the risks of seed oils, the overhyped reputation of “health foods” like quinoa, and the critical roles insulin and nutrient density play in overall wellness. With insights on balancing mTOR, managing omega fats, and incorporating organ meats, this episode offers a nuanced perspective for anyone interested in biohacking, nutrition science, or simply eating smarter. What you’ll learn:  • Why metabolic flexibility matters more than strict diet rules  • The science behind long-term ketosis and insulin’s broader role in health  • How common “health foods” could be doing more harm than good  • The importance of nutrient-dense animal-based foods for gut and immune health  • How to achieve optimal balance between fat types, mTOR, and longevity markers Resources:  2025 Biohacking Conference – https://biohackingconference.com/2025 Shop Paul Saladino’s Products – https://heartandsoil.co Follow Paul Saladino on Instagram – https://www.instagram.com/paulsaladinomd/ Paul Saladino’s Book: The Carnivore Code – https://www.amazon.com/Carnivore-Code-Unlocking-Returning-Ancestral/dp/035846997X Lineage Provisions – 100% Grass-Fed Beef Tallow – https://lineageprovisions.com/products/100-grass-fed-beef-tallow Danger Coffee – https://dangercoffee.com Danger Coffee Instagram – https://www.instagram.com/dangercoffeeofficial/ Dave Asprey’s Website – https://daveasprey.com Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books Dave Asprey’s Linktree – https://linktr.ee/daveasprey Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com Own an Upgrade Labs – https://ownanupgradelabs.com Upgrade Labs – https://upgradelabs.com 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement – https://40yearsofzen.com Sponsors: - Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. - LMNT | Free LMNT Sample Pack with any drink mix purchase by going to https://drinklmnt.com/dave. Timestamps: • 00:00 Intro • 00:40 Paul Saladino’s Evolution in Diet • 01:21 Challenges of a Strict Carnivore Diet • 03:36 Reintroducing Carbohydrates • 05:32 Debunking Common Diet Myths • 13:49 The Problem with Calorie Restriction • 18:30 The Importance of Food Quality • 24:08 The Veganism Debate • 34:15 The Benefits of Organ Meats • 37:27 Foot Surgery and Bone Density • 39:23 Mineral Deficiency and Plant-Based Diets • 40:00 The Truth About Seed Oils • 41:10 Historical Studies on Seed Oils • 47:26 Mechanisms and Effects of Seed Oils • 52:33 Nicotine and Neuroprotection • 54:12 Oleic Acid and Longevity • 01:01:44 The Benefits of Animal Fats• 01:02:32 Odd Chain Fatty Acids and Health • 01:11:07 Cheese and Dairy Considerations • 01:13:11 The Impact of Cheese on Health • 01:14:03 Protein Intake and Longevity • 01:14:54 Understanding mTOR and Its Effects • 01:17:35 Ideal Body Fat and Metabolic Health • 01:24:38 The Role of Omega Fatty Acids • 01:32:46 ApoB, Insulin Sensitivity, and Longevity • 01:43:09 Final Thoughts and Product Recommendations  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What are the oral hygiene tips that could save your life?  Dave Asprey sits down with one of the most popular guests on the show, Naveen Jain, founder and CEO of Viome Life Sciences, to explore how your oral microbiome influences not just your dental health but your entire body. Naveen reveals groundbreaking insights into how imbalances in oral bacteria can trigger chronic inflammation, heart disease, and even cancer—and how understanding your unique microbiome can help prevent these risks. Discover why oral health goes far beyond brushing and flossing, how to optimize your oral microbiome for longevity, and why common mouthwashes may be doing more harm than good. Naveen also introduces cutting-edge solutions from Viome, including personalized oral lozenges and postbiotics, to elevate both your oral and overall health. In this episode, you’ll also uncover the exact foods to eat and avoid to live a longer, healthier, and more vibrant life. What you’ll learn in this episode:  • The surprising link between your oral microbiome and chronic disease  • Why bacterial diversity in your mouth is essential for overall health  • How leaky gums drive systemic inflammation and increase health risks  • The dangers of over-sterilizing your mouth and eliminating beneficial bacteria  • Personalized solutions to improve oral and gut health with Viome  • Actionable tips to optimize your oral microbiome for better longevity Resources:   • 2025 Biohacking Conference – https://biohackingconference.com/2025  • Viome Full Body Intelligence Test (Save $110) – https://www.viome.com/dave  • Viome Instagram – https://www.instagram.com/viome  • Learn More About Viome – https://viome.com  • Danger Coffee – https://dangercoffee.com  • Danger Coffee Instagram – https://www.instagram.com/dangercoffeeofficial/  • Dave Asprey’s Website – https://daveasprey.com  • Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books  • Dave Asprey’s Linktree – https://linktr.ee/daveasprey  • Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com  • Own an Upgrade Labs – https://ownanupgradelabs.com  • Upgrade Labs – https://upgradelabs.com  • 40 Years of Zen – Neurofeedback training for advanced cognitive enhancement – https://40yearsofzen.com Sponsors: -Leela Quantum | Head to https://leelaq.com/DAVE for 10% off. -ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order. Timestamps:  • 00:00 Introduction to Viome and Its Impact on Health  • 00:53 Meet Naveen Jain: Visionary Behind Viome  • 02:41 Understanding the Microbiome and Its Role in Health  • 05:54 The Power of RNA Analysis in Personalized Health  • 12:19 Diet, Microbiome, and Personalized Nutrition  • 29:50 The Importance of Oral and Gut Health  • 39:20 Debating the Benefits of Intermittent Fasting  • 40:08 The Role of Gut Bacteria in Fasting and Diet  • 42:12 Understanding Chronic Inflammation and Diet  • 44:13 The Keto Diet Myths and Realities  • 45:44 Oxalates and Superfoods What You Need to Know  • 49:25 The Concept of Holobiont and Human Health  • 56:21 The Five Pillars of Longevity  • 01:02:04 The Importance of Quality Sleep  • 01:05:18 Purpose and Community for a Longer Life  • 01:09:48 Upcoming Topics and Final Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Is this the missing link in fertility? The vaginal microbiome could be the most overlooked factor in optimizing women’s health, from fertility and hormonal balance to preventing infections and improving quality of life. In this groundbreaking episode, Dave Asprey talks to Priyanka Jain, co-founder and CEO of Evvy, about how understanding and improving the vaginal microbiome can transform women’s health outcomes. Priyanka shares how Evvy is advancing women’s health through cutting-edge genomic research and AI-powered insights, offering solutions to challenges like bacterial vaginosis, yeast infections, recurrent UTIs, and even infertility. You’ll learn why this critical microbiome plays such a vital role, how hormonal changes and lifestyle impact it, and how personalized approaches can improve reproductive and overall health. This episode explores not just women’s health but also how understanding the vaginal microbiome can influence relationships, biohacking, and even groundbreaking fertility research. Don’t miss this deep dive into the science and solutions shaping the future of health. Here’s what you’ll learn in this episode:  • The critical role the vaginal microbiome plays in women’s health and fertility  • How hormonal changes affect vaginal health and microbiome balance  • The link between vaginal microbiome imbalances and conditions like bacterial vaginosis, yeast infections, and UTIs  • Evvy’s innovative approach to using AI and genomics for personalized health insights  • Practical tips for maintaining microbiome health, including probiotics, hydration, and hormone balance  • The connection between the vaginal microbiome and overall quality of life  Resources:   • 2025 Biohacking Conference – https://biohackingconference.com/2025  • Shop at Evvy (Use coupon code DAVE for $10 off!) – https://shareasale.com/r.cfm?b=1862577&u=2810239&m=116251&urllink=&afftrack= (Use coupon code DAVE for $10 off!)  • Follow Evvy on Instagram – https://www.instagram.com/evvy  • Danger Coffee – https://dangercoffee.com  • Danger Coffee Instagram – https://www.instagram.com/dangercoffeeofficial/  • Dave Asprey’s Website – https://daveasprey.com  • Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books  • Dave Asprey’s Linktree – https://linktr.ee/daveasprey  • Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com  • Own an Upgrade Labs – https://ownanupgradelabs.com  • Upgrade Labs – https://upgradelabs.com  • 40 Years of Zen – Neurofeedback training for advanced cognitive enhancement – https://40yearsofzen.com Sponsors: - Calroy | Head to https://calroy.com/dave for an exclusive discount. Timestamps:  • 00:00 Trailer  • 00:35 Introduction to Vaginal Microbiome  • 01:12 Meet Priyanka Jain of Evvy  • 02:03 Understanding the Vaginal Microbiome  • 04:37 Challenges in Women’s Health  • 09:55 Impact of Lifestyle on Vaginal Health  • 11:22 The Role of Diet and Supplements  • 15:24 Sexual Health and Vaginal Microbiome  • 27:25 Menopause and Vaginal Health  • 31:23 Optimizing Vaginal Health  • 39:31 Exploring Women’s Health Data  • 41:17 The Role of Vaginal Microbiome in Fertility  • 43:44 Affordable Testing and Discount Offers  • 45:31 The Impact of Lubricants on Vaginal Health  • 46:20 Innovative Ideas for Probiotic Products  • 47:29 Audience Questions and Precision Medicine  • 48:04 The Importance of Data in Women’s Health  • 54:31 Marketing and Misinformation in Vaginal Health  • 01:06:34 The Connection Between Diet and Vaginal Health  • 01:12:49 Conclusion and Final Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Is alcohol losing its grip as the go-to social drink? Enter kava—a centuries-old Polynesian plant that’s gaining global recognition for its ability to relax the mind, elevate mood, and enhance social connection without the toxic effects of alcohol. Kava, particularly in the form of TRU KAVA, is a psychoactive yet non-intoxicating drink that offers the perfect balance of calm focus and mental clarity. In this episode, Dave Asprey welcomes Cameron George, founder of TRU KAVA, to discuss why kava is becoming the drink of choice for those seeking a healthier, more connected lifestyle. Learn how kava impacts neurotransmitters like GABA and dopamine, enhances creativity and emotional grounding, and even helps the body recover from stress and trauma. Discover why kava is taking center stage in the biohacking and sober-curious movements as a new tool for wellness and connection. Here’s what you’ll learn in this episode:  • Why 41% of Americans and 61% of Gen Z are drinking less alcohol  • What kava is, how it works, and its history as a ceremonial and social beverage  • The science behind kava’s calming and neuroprotective effects  • How kava supports creativity, emotional resilience, and authentic social connection  • Practical uses for kava, including stress relief, sleep enhancement, and travel recovery  Resources:  • 2025 Biohacking Conference – https://biohackingconference.com/2025 • TRU KAVA – https://www.trukava.com • TRU KAVA Instagram – https://www.instagram.com/trukava • Danger Coffee – https://dangercoffee.com • Danger Coffee Instagram – https://www.instagram.com/dangercoffeeofficial/ • Dave Asprey’s Website – https://daveasprey.com • Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books • Dave Asprey’s Linktree – https://linktr.ee/daveasprey • Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com • Own an Upgrade Labs – https://ownanupgradelabs.com • Upgrade Labs – https://upgradelabs.com • 40 Years of Zen – Neurofeedback training for advanced cognitive enhancement – https://40yearsofzen.com Sponsors: -Quantum Upgrade |Go to https://quantumupgrade.io/Dave for a free trial. -Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. Timestamps:  • 00:00 Intro  • 00:37 Introduction to Alcohol Trends  • 01:57 Meet Cameron George and TRU KAVA  • 02:29 What is Kava?  • 05:03 Kava’s Effects on the Brain  • 06:53 Kava vs. Alcohol  • 08:54 Active Compounds in Kava  • 10:10 Kava’s Safety and Standardization  • 16:17 Kava in Social Settings  • 21:28 Kava and Psychedelics  • 31:26 Kava for Public Speaking and Anxiety  • 34:04 Kava in the Workplace: Enhancing Team Creativity  • 35:22 Kava and Libido: The Unexpected Benefits  • 36:06 Biohacking with Kava: Energy Allocation and Community  • 39:00 Kava’s Role in Meditation and Emotional Awareness  • 42:04 Kava During Pregnancy: Safety and Traditions  • 44:37 Kava’s Neuroprotective Properties: A Deep Dive  • 45:49 Kava and EMF Sensitivity: A Surprising Connection  • 48:39 Kava for Frequent Travelers: Enhancing Mitochondrial Health  • 52:46 Kava and Metabolic Health: Fasting and Fat Burning  • 57:14 Kava Products: Oils, Beverages, and Their Uses  • 01:01:27 The Future of Kava: Social Impact and Cultural Integration  • 01:05:28 Conclusion: The Potential of Kava in Modern Society See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Have we finally discovered the key to youthful energy, longevity, and cellular health? In this episode, Dave Asprey sits down with Dr. Anurag Singh, Chief Medical Officer at Timeline Nutrition and a leading expert on mitochondrial health, cellular regeneration, and anti-aging science. With over 20 years of research, 50 clinical trials, and 15 patents under his belt, Dr. Singh unpacks the groundbreaking science behind Urolithin A, a revolutionary postbiotic that boosts mitochondrial function, enhances immune system resilience, and combats chronic inflammation. This episode goes beyond cutting-edge science. Dr. Singh reveals practical, real-world strategies to combat “inflammaging”—the chronic, low-grade inflammation that accelerates aging. Learn how fasting, gut health, and mitochondrial boosters like Urolithin A can rejuvenate your cells, fight fatigue, and supercharge your energy, vitality, and longevity. Here’s what you’ll learn in this episode:  • What Urolithin A is and its role in mitochondrial health and cellular energy production  • How to reverse “inflammaging” and reduce inflammation through nutrition, fasting, and biohacking  • The connection between mitochondrial dysfunction and immune system aging  • Real-life benefits of Urolithin A for energy levels, athletic recovery, skin health, and longevity  • Why mitochondrial support is critical for combating aging and improving overall performance  Resources:   • 2025 Biohacking Conference – https://biohackingconference.com/2025   • Timeline Nutrition -  https://www.timeline.com/dave to get 10% off your first order   • Timeline Instagram – https://www.instagram.com/timeline_longevity/   • Dave Asprey’s Website – https://daveasprey.com   • Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books   • Danger Coffee – https://dangercoffee.com   • Danger Coffee Instagram – https://www.instagram.com/dangercoffeeofficial/   • Dave Asprey’s Linktree – https://linktr.ee/daveasprey   • Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com   • Own an Upgrade Labs – https://ownanupgradelabs.com   • Upgrade Labs – https://upgradelabs.com   • 40 Years of Zen – Neurofeedback training for advanced cognitive enhancement – https://40yearsofzen.com  Timestamps:  • 00:00 Introduction to Longevity and Mitochondria  • 01:28 The Role of Mitochondria in Immune Health  • 03:36 Understanding Inflammaging and Immune Aging  • 07:47 Measuring Immune Health and Inflammation  • 13:33 Urolithin A: A Mitochondrial Booster  • 16:46 Dosage and Effects of Urolithin A  • 26:11 Urolithin A and Exercise Performance  • 28:31 Urolithin A for Skin Health  • 31:34 Collagen and Aging: The Role of MMPs  • 33:27 Personal Experience with MMPs and Recovery  • 35:04 Measuring MMPs and Their Impact on Longevity  • 36:18 Skin Health and Urolithin A  • 38:39 Exploring Urolithin A’s Broader Benefits  • 40:33 Brain Health and Urolithin A  • 43:33 Combining Supplements for Optimal Health  • 45:54 Omega-3s and Mitochondrial Health  • 46:51 Ketones, MCTs, and Urolithin A  • 54:30 Final Thoughts on MitoPure and Supplementation See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Are exosomes the planet’s ultimate healing tool?! In this episode, Dave Asprey sits down with Harvard-trained physician Dr. Edward Park to explore the groundbreaking science of exosomes. Dr. Park, a pioneer in regenerative medicine and author of Exosomes: Songs of Healing, explains how these tiny cellular messengers are revolutionizing health and longevity by bypassing the limitations of stem cells. BUT this episode isn’t just about cutting-edge science. Dr. Park also shares profound insights into life, resilience, and emotional well-being, offering advice that goes far beyond medicine. From the power of forgiveness to breaking free of limiting beliefs, his perspective blends science, spirituality, and practical wisdom for living a better life. Here’s what you’ll learn in this episode:  • How exosomes work and why they’re being called the future of regenerative medicine  • The key differences between exosomes and stem cells—and which is better for healing  • Real-life applications of exosome therapy for injuries, anti-aging, and overall health  • The potential of exosomes to enhance brain function, reduce inflammation, and promote recovery  • Dr. Park’s advice on emotional resilience, gratitude, and creating lasting change With over a decade of experience, Dr. Park shares compelling case studies, cutting-edge insights, and practical advice for anyone looking to upgrade their body, mind, and life. Whether you’re managing chronic pain, exploring anti-aging therapies, or seeking wisdom for navigating life’s challenges, this episode has something for everyone. Sponsors TRU KAVA | Go to https://trukava.com and enter code DAVE15 at checkout for 15% off  Resources: • 2025 Biohacking Conference – https://biohackingconference.com/2025 • Dr. Edward Park’s Website: Recharge Biomedical – https://www.rechargebiomedical.com • Dr. Edward Park’s Book: Exosomes: Songs of Healing – https://www.amazon.com/EXOSOMES-Songs-Healing-Ed-Park/dp/098260632X • Dr. Edward Park’s YouTube Channel – https://www.youtube.com/channel/UCpp9DlRArB1rKAWNwoouiTg • Dr. Edward Park on Instagram – https://www.instagram.com/dredpark/ • Dave Asprey’s Website – https://daveasprey.com • Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books • Danger Coffee – https://dangercoffee.com • Danger Coffee Instagram – https://www.instagram.com/dangercoffeeofficial/ • Dave Asprey’s Linktree – https://linktr.ee/daveasprey • Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com • Own an Upgrade Labs – https://ownanupgradelabs.com • Upgrade Labs – https://upgradelabs.com • 40 Years of Zen – Neurofeedback training for advanced cognitive enhancement – https://40yearsofzen.com  Timestamps:  • 00:00 Introduction to Exosomes and Healing  • 00:48 Understanding Exosomes: Stem Cell Communication  • 01:19 Dr. Edward Park’s Insights on Exosomes  • 02:47 Exosomes vs. Traditional Treatments  • 04:44 Exosomes in Regenerative Medicine  • 07:33 Cost-Effective Regeneration Protocols  • 12:35 Exosomes for Hair Growth  • 14:37 Stem Cells and Brain Health  • 25:33 Banking Stem Cells for Future Use  • 35:27 Epigenetic Age and Longevity Predictors  • 37:48 CRISPR and Gene Editing: Risks and Benefits  • 39:43 Basic Health Tips for Longevity  • 41:02 Spirituality, Past Lives, and Healing  • 42:50 Questioning Medical and Political Narratives  • 47:54 The Importance of Free Speech  • 01:07:40 The Role of Intuition in Medicine  • 01:09:22 Conclusion and Final Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Is biohacking your sweat the secret to vitality? Dave Asprey dives into the transformative world of infrared saunas with Connie Zack, founder of Sunlighten and a 25-year innovator in the space. Together, they uncover how targeted light and heat therapy can unlock unparalleled health benefits, from detoxing heavy metals to energizing your body at the cellular level. Here’s what you’ll learn in this episode: • Why infrared saunas excel at detoxing heavy metals and toxins • How they mimic exercise to boost cardiovascular health and recovery • The science behind infrared’s impact on mitochondrial energy and longevity • Surprising benefits for gut health, inflammation, and hormone balance • Hacks to get the most out of your infrared sauna sessions Connie shares cutting-edge research and personal insights, offering practical ways to integrate infrared therapy into your routine. Whether you’re looking to recover faster, improve your mood, or support long-term health, this episode delivers the tools you need to take your biohacking game to the next level. Special Offer: Use code “DAVE” at sunlighten.com to get up to $1,000 off until December 6th! Sponsors:-ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order. -fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. Resources: • Sunlighten Saunas Website – https://www.sunlighten.com/dave/?utm_source=DaveAsprey&utm_medium=Partner&utm_content=Podcast&leadsource=DaveAsprey&utm_campaign=DaveAsprey • Sunlighten Saunas on Instagram – https://www.instagram.com/sunlightensaunas/    • 2025 Biohacking Conference – https://biohackingconference.com/2025 • Dave Asprey’s Website – https://daveasprey.com • Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books • Danger Coffee – https://dangercoffee.com • Danger Coffee Instagram – https://www.instagram.com/dangercoffeeofficial/ • Dave Asprey’s Linktree – https://linktr.ee/daveasprey • Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com • Own an Upgrade Labs – https://ownanupgradelabs.com • Upgrade Labs – https://upgradelabs.com • 40 Years of Zen – Neurofeedback training for advanced cognitive enhancement – https://40yearsofzen.com Timestamps  • 00:00 Introduction to Infrared Saunas • 00:27 Meet Connie Zack: Leading Voice in Infrared Saunas • 00:50 The Science Behind Infrared Saunas • 02:35 Infrared Saunas vs. Traditional Saunas • 05:41 Health Benefits of Infrared Saunas • 08:14 Technological Advancements in Infrared Saunas • 17:36 The Role of LEDs in Infrared Saunas • 22:37 Practical Tips and Personal Experiences • 28:14 Detoxing and Energizing with Glutathione • 28:40 Pre and Post-Sauna Rituals • 29:05 Habit Stacking in the Sauna • 29:41 Managing Overheating Devices • 31:05 Creative Breakthroughs in the Sauna • 32:14 Scientific Method and Personal Experience • 36:05 Understanding Glucose Spikes • 38:44 Longevity Benefits of Infrared Saunas • 43:27 Infrared Saunas and Skin Health • 45:29 Extreme Detox Protocols • 48:28 Grip Strength and Longevity • 50:34 Customizing Your Sauna Experience See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What if you could command any room and set boundaries without saying a word? Dave Asprey sits down with Kasia Urbaniak, founder and CEO of The Academy—a trailblazing school where women learn the true principles of influence and authority. Kasia brings a unique and dynamic perspective, drawing on nearly two decades of experience that includes working as a professional Dominatrix, practicing Taoist alchemy in one of China’s oldest female-led monasteries, and earning certifications across disciplines like Medical Qi Gong and Systemic Constellations. Here’s what you’ll learn in this episode: • How to set clear, unbreakable boundaries in any situation • Techniques for wielding influence without sacrificing integrity • Tools to reclaim inner authority and navigate life with confidence • Practical strategies for handling power dynamics in relationships, work, and beyond Kasia’s methods have empowered over 4,000 women worldwide to step into leadership roles in every sphere, from personal relationships to professional arenas. In this episode, she shares practical insights on transforming how you’re perceived by others and, more importantly, how you perceive yourself. Whether you’re navigating complex workplace dynamics, strengthening personal boundaries, or seeking clarity in relationships, Kasia’s teachings offer a path to reclaiming the powerful, authentic authority within you. Sponsors -Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order.  -LMNT | Free LMNT Sample Pack with any drink mix purchase by going to https://drinklmnt.com/dave.  Resources: • 2025 Biohacking Conference – https://biohackingconference.com/2025 • Kasia Urbaniak’s Website – https://www.kasiaurbaniak.com • Kasia Urbaniak’s Book: Unbound: A Woman’s Guide to Power – https://www.kasiaurbaniak.com/unbound • The Academy – Practical Training for Women on Power and Influence – https://www.kasiaurbaniak.com/the-academy • Kasia Urbaniak on Instagram – https://www.instagram.com/kasiaurbaniak/ • Dave Asprey’s Website – https://daveasprey.com • Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books • Danger Coffee – https://dangercoffee.com • Danger Coffee Instagram – https://www.instagram.com/dangercoffeeofficial/ • Dave Asprey’s Linktree – https://linktr.ee/daveasprey • Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com • Own an Upgrade Labs – https://ownanupgradelabs.com • Upgrade Labs – https://upgradelabs.com • 40 Years of Zen – Neurofeedback training for advanced cognitive enhancement – https://40yearsofzen.com Timestamps: • 00:00 Introduction to the Human Upgrade • 01:07 Meet Kasia Urbaniak: Author of Unbound • 02:52 Exploring Power Dynamics • 04:46 The Role of Emotions in Power • 14:50 Embodiment and Somatic Work • 32:58 The Power of Voice and Presence • 48:22 Collective Intelligence and Intuition • 54:50 Facing Fears and Intuition • 55:15 Male vs. Female Intuition • 56:01 The Power of Erotic Energy • 57:13 Welcoming Emotions and States • 59:10 Role-Playing and Personas • 01:00:06 Teaching Women to Speak Up • 01:02:04 Energetic Dynamics in Relationships • 01:04:35 Victimhood and Healing • 01:19:54 The Power of Asking • 01:29:40 Money and Emotional Alchemy • 01:31:53 Shameless Money Conversations • 01:44:00 Final Thoughts and Upcoming Events See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Is unlocking the full potential of your brain even possible, or just a myth from the movie Limitless? In this eye-opening episode, neuroscientist and author Dr. Mithu Storoni joins Dave to dive deep into the science of brain optimization for hyper-efficient work performance. Together, they break down the surprising roles of astrocytes in supporting neurons, the influence of the brain’s “blue dot” region (the locus coeruleus) on focus and mental clarity, and how harnessing neuroplasticity can lead to improved cognitive efficiency and resilience in high-stress environments. Get ready to discover actionable science-backed hacks for enhancing work productivity and maintaining focus—even in the face of constant distractions. Dr. Storoni also explains how optimizing your breathing rhythm, managing your brain’s arousal state, and tapping into the natural flow of ultradian rhythms can dramatically improve your mental output. Whether you’re looking to elevate your workflow, supercharge your mental performance, or unlock the science of hyper-efficiency, this episode delivers essential strategies to cultivate a high-performing mind for work and beyond. Tune in to understand how the latest neuroscience can transform how you think, focus, and excel every day. Sponsors -Quantum Upgrade | Go to Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial. -Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order. Resources: • Dr. Mithu Storoni’s Website – https://www.mithustoroni.com • Hyper Efficient: Optimize Your Brain to Transform the Way You Work by Dr. Mithu Storoni – https://www.hachettebookgroup.com/titles/mithu-storoni/hyperefficient/9780316566933/ • Dr. Mithu Storoni on Facebook – https://www.facebook.com/drmithustoroni/ • Dr. Mithu Storoni’s LinkedIn – https://www.linkedin.com/in/mithu-storoni-0488872a/ • Dave Asprey’s Website – https://daveasprey.com • Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books • Danger Coffee – https://dangercoffee.com • Danger Coffee Instagram – https://www.instagram.com/dangercoffeeofficial/ • Dave Asprey’s Linktree – https://linktr.ee/daveasprey • Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com • Own an Upgrade Labs – https://ownanupgradelabs.com • Upgrade Labs – https://upgradelabs.com • 40 Years of Zen – Neurofeedback training for advanced cognitive enhancement – https://40yearsofzen.com Timestamps • 00:00 – Introduction to Brain Complexity • 00:29 – The Human Upgrade with Dave Asprey • 01:42 – Meet Dr. Mijtu Storoni • 02:16 – Understanding Brain Efficiency • 02:57 – The Role of Astrocytes • 04:37 – Brain Adaptability and Environment • 06:55 – Biohacking and Environmental Signals • 08:34 – Power vs. Efficiency Debate • 11:26 – The Importance of Glial Cells • 18:10 – The Brain as a Predictive Machine • 23:14 – Nutrition and Brain Health • 32:33 – The Gut-Brain Connection • 36:36 – Eye Health as a Proxy for Brain Health • 40:47 – Aligning the Brain: The Blue Dot Network • 41:54 – Understanding Brain Gears and Stress Management • 42:27 – Maintaining the Goldilocks Zone for Optimal Brain Function • 43:09 – The Role of Creativity and Daydreaming • 44:28 – Strategies to Stay in Optimal Mental States • 47:44 – Biohacking for Enhanced Efficiency • 51:00 – The Science Behind Flow States • 57:09 – Harnessing Innate Curiosity for Mental Efficiency • 01:03:46 – Breathing Techniques for Mental Regulation • 01:13:32 – The Importance of Ultradian Rhythms • 01:17:40 – Practical Tips for Efficient Breaks • 01:21:20 – Conclusion: Embracing Hyper Efficiency See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What if the keys to an extraordinary life lie in choices most people wouldn’t dare to make? In this iconic, unearthed episode, best-selling author and performance pioneer Tim Ferriss joins Dave Asprey to spill the unfiltered truth on smart drugs, insect protein, and the surprising links between sex, creativity, and high performance. They dig into cutting-edge topics still sparking curiosity today: the calculated risks and rewards of smart drugs, the future-forward benefits of insect protein, and how unconventional habits fuel creativity and peak performance. Tim candidly shares his personal protocols, from routine blood testing to strategic supplementation, all rooted in his philosophy that “the dose makes the poison.” As a powerful wrap-up, Tim lays out his top three life principles for real success: choosing high-caliber people, focusing on those who “get it,” and setting audacious, even wild, goals. Whether you’re biohacking or simply intrigued, this episode delivers timeless insights and bold ideas for anyone ready to unlock a high-performance life. Sponsors -Timeline | Head to https://www.timeline.com/dave to get 10% off your first order.  -Pendulum | Go to https://pendulumlife.com/ and use code Asprey20 for your first month of GLP-1 or any Pendulum formula. Resources:  • Tim Ferriss’ Website – https://tim.blog  • Tim Ferriss’ Book Club – http://fourhourbook.club/  • Tim Ferriss’ Podcast – https://tim.blog/podcast/  • Dave Asprey’s Website – https://daveasprey.com  • Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books  • Danger Coffee – https://dangercoffee.com  • Danger Coffee Instagram – https://www.instagram.com/dangercoffeeofficial/  • Dave Asprey’s Linktree – https://linktr.ee/daveasprey  • Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com  • Own an Upgrade Labs – https://ownanupgradelabs.com  • Upgrade Labs – https://upgradelabs.com  • 40 Years of Zen – Neurofeedback training for advanced cognitive enhancement – https://40yearsofzen.com Timestamps  • 00:00 Introduction to Early Episodes  • 00:57 The Human Upgrade with Tim Ferriss  • 01:58 Smart Drugs and Their Effects  • 05:09 Experimenting with Health and Performance  • 13:53 The Role of Creativity and Writing  • 17:05 Exploring Nutrition and Insect Protein  • 21:01 Handling Criticism and Audience Responsibility  • 30:04 Sex, Performance, and Longevity  • 33:21 Tim Ferriss’ Top Three Life Tips   See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What if everything you believe about happiness is wrong? In this episode, Harvard professor and world-renowned happiness expert Arthur Brooks joins Dave Asprey to unlock the secrets of real happiness, revealing the science behind joy, resilience, and lasting fulfillment. As a bestselling author and co-author with Oprah Winfrey of Build the Life You Want, Arthur has spent decades helping people rethink happiness through a blend of psychology, neuroscience, and ancient wisdom. Together, Dave and Arthur explore eye-opening topics like the “reverse bucket list,” why dopamine-driven goals often lead to disappointment, and how embracing discomfort can actually create deeper contentment. Arthur dives into why our common pursuits of fame, wealth, and success often fall short, and shares powerful strategies for mastering what’s within our control, building resilience, and finding meaning in life’s simplest moments. From managing dopamine to harnessing the power of small wins, this episode offers science-backed insights and practical tools to elevate your life with lasting joy and purpose. If you’re ready to transform your approach to happiness, tune in for strategies that truly work.  Sponsors Leela Quantum | Head to https://leelaq.com/DAVE for 10% off. ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order. Resources:  • Arthur Brooks’ Website – https://arthurbrooks.com  • Arthur Brooks’ TED Talk: A New Way to Think About Happiness – https://www.ted.com/talks/arthur_brooks_the_art_and_science_of_happiness?subtitle=en&geo=es • Arthur Brooks’ Weekly Column: How to Build a Life in The Atlantic – https://www.theatlantic.com/author/arthur-c-brooks/  • Dave Asprey’s Website – https://daveasprey.com  • Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books  • Danger Coffee – https://dangercoffee.com  • Danger Coffee Instagram – https://www.instagram.com/dangercoffeeofficial/  • Dave Asprey’s Linktree – https://linktr.ee/daveasprey  • Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com  • Own an Upgrade Labs – https://ownanupgradelabs.com  • Upgrade Labs – https://upgradelabs.com  • 40 Years of Zen – Neurofeedback training for advanced cognitive enhancement – https://40yearsofzen.com    Timestamps • 00:00 – Introduction to Reverse Bucket List • 00:35 – The Science of Happiness • 00:58 – Personal Journey to Happiness • 01:44 – Meet Arthur Brooks • 04:26 – The Role of Music in Emotions • 07:43 – Understanding Emotions and the Brain • 09:50 – Parenting and Influence • 18:06 – Public Speaking and Performance • 34:10 – Striving for Success and Happiness • 39:40 – The Struggle with Body Image and Nutrition • 40:03 – Reverse Bucket List: Assessing Attachments • 40:57 – The Science of Dopamine and Motivation • 43:09 – The Dangers of Pornography and Dopamine • 44:03 – Biohacking and Pain Management • 47:03 – The Importance of Small Wins • 48:48 – Embracing Pain and Discomfort • 53:01 – The Role of Pain in Personal Growth • 56:12 – The Concept of Non-Resistance • 57:17 – The Happiness of Strivers • 01:01:13 – The Importance of Relationships and Spiritual Life • 01:03:22 – The Role of Fame and Legacy • 01:16:31 – The Value of Truthfulness and Compassion • 01:17:59 – Conclusion and Final Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Explore the science and potential of hypnosis as Dr. David Spiegel, Stanford’s leading expert in mind-body medicine, joins Dave Asprey to reveal how hypnosis can radically enhance cognition, mental clarity, and resilience. In this episode of The Human Upgrade, you’ll learn how hypnosis influences the brain’s most vital networks, including the default mode network and executive control, to break mental barriers and amplify focus, perception, and healing. Discover how hypnosis, unlike traditional meditation or neurofeedback, accelerates response times, manages pain, and even helps alleviate PTSD. Dr. Spiegel shares stories of patients overcoming chronic pain and trauma through self-hypnosis, and details the mechanisms that make hypnosis a powerful tool for emotional and physical transformation. Dive into the fascinating brain science behind the practice, from theta brainwave induction to deep sensory modulation, and learn simple self-hypnosis techniques that can elevate mental performance, improve sleep quality, and instill lasting calm. If you’re seeking a powerful, accessible way to biohack your brain and harness the potential of your mind, this episode delivers the insights and tools you need to make hypnosis your ultimate cognitive upgrade.   Sponsors Quantum Upgrade | Go to Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial. Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order. Resources: • Dr. David Spiegel’s Website – https://med.stanford.edu/profiles/david-spiegel • Reveri Hypnosis App – https://reveri.com (available on App Store and Google Play) • Dave Asprey’s Website – https://daveasprey.com • Danger Coffee – https://dangercoffee.com • Danger Coffee Instagram – https://www.instagram.com/dangercoffeeofficial/ • Dave Asprey’s Linktree – https://linktr.ee/daveasprey • Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books • Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com • Own an Upgrade Labs – https://ownanupgradelabs.com • Upgrade Labs – https://upgradelabs.com • 40 Years of Zen – Neurofeedback training for advanced cognitive enhancement https://40yearsofzen.com Timestamps • 00:00 – Introduction to Hypnosis • 00:59 – Dave Asprey Introduces Dr. David Spiegel • 02:03 – Dr. Spiegel’s Journey into Hypnotherapy • 06:06 – The Power of Hypnosis in Medical Practice • 11:19 – Understanding Hypnosis and Brain Function • 16:14 – Hypnosis for PTSD and Trauma • 19:33 – Hypnosis vs. EMDR: Key Differences • 22:30 – Pain Management through Hypnosis • 31:06 – The Impact of Psychedelics on Cancer Patients • 33:04 – Exploring Psychedelic-Assisted Neurofeedback • 34:05 – Neuroimaging and Brain Activity in Hypnosis • 35:22 – Hypnosis and Cognitive Enhancement • 38:53 – Hypnosis for Sleep and Stress Management • 42:26 – Hypnosis and the “Manchurian Candidate” Concept • 48:21 – Hypnosis and the Immune System • 53:11 – Live Hypnosis Session with Dave Asprey • 58:46 – Conclusion and Final Thoughts  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Unlock the mastermind secrets to cognitive enhancement as Dave Asprey shares his ultimate brain-boosting biohacks in this powerful episode of The Human Upgrade. Discover how Dave elevated his IQ, reversed Asperger’s, and overcame brain fog through advanced neurofeedback, BDNF-boosting supplements, mitochondrial enhancers, and the power of the groundbreaking 40 Years of Zen program. Explore revolutionary techniques, from ancient meditation practices to modern nootropics and smart drugs, all designed to amplify memory, focus, and resilience. Learn the science behind cognitive enhancement, from ketones like C8 MCT oil to essential supplements like Vitamins D, K, A, and magnesium that fuel optimal brain function. If you’re seeking proven methods to enhance neuroplasticity, boost mental endurance, or reduce brain fog, this episode is packed with actionable insights. Whether you’re aiming to maximize mental performance or unlock the latest in brain science, Dave’s mastermind approach offers a comprehensive guide to upgrading your mind and achieving peak potential. Prepare to boost cognitive abilities, harness your mind’s true power, and achieve new levels of clarity with Dave’s most effective brain and body biohacks—culminating in the transformative experience of 40 Years of Zen. Sponsors40 Years of Zen | Neurofeedback training for advanced cognitive enhancement https://40yearsofzen.com/upgrade/Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order.Pendulum | Go to https://pendulumlife.com/ and use code Asprey20 for your first month of GLP-1 or any Pendulum formula.Resources: • Dave Asprey’s Website – https://daveasprey.com • Danger Coffee – https://dangercoffee.com • Danger Coffee Instagram – https://www.instagram.com/dangercoffeeofficial/ • Dave Asprey’s Linktree – https://linktr.ee/daveasprey • Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books • Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com • Own an Upgrade Labs – https://ownanupgradelabs.com • Upgrade Labs – https://upgradelabs.com • Mendi Neurofeedback Device – Home neurofeedback device for attention and focus improvement https://www.mendi.io • Ketone IQ by HVMN – Go to https://ketone.com/dave for 30% off your first subscription of Ketone IQ.• Qualia NAD – Support for mitochondrial function and cellular energy https://qualialife.com/dave (use code DAVE for discounts) • Vitamin DAKE – Fat-soluble vitamin complex designed by Dave Asprey https://vitamindake.com • Minerals 101 – Comprehensive mineral supplement for cognitive and metabolic support https://shopsuppgradelabs.com/products/minerals-101  Timestamps: • 00:00 Intro • 00:32 Introduction to Cognitive Enhancement • 01:41 Dave’s Personal Journey and Struggles • 04:15 Discovering Cognitive Enhancement Tools • 11:36 Exploring Neurofeedback and Brain Training • 14:22 The Power of Mitochondria and Neuroplasticity • 23:45 Supplements for Cognitive Enhancement • 32:33 The Role of NAD+ in Brain Function • 34:41 Foundational Supplements for Brain Health • 36:17 Essential Supplements for Cognitive Function • 37:29 The Importance of Magnesium and Zinc • 39:14 Meditation and Breath Work for Brain Health • 40:07 Avoiding Toxins for Better Brain Function • 42:56 The Impact of EMFs on Brain Health • 46:25 Neurofeedback and Cognitive Enhancement • 01:05:01 The Power of Ketamine in Neurofeedback • 01:09:49 Final Thoughts and Recommendations • 01:09:49 Testimonials  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.