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A recent study in Advanced Healthcare Materials reports a novel method for regenerating tooth enamel using water-based films made from keratin, a protein abundant in sources like wool. Researchers found that these keratin films can self-assemble into organized scaffolds that guide the growth of aligned apatite nanocrystals, mimicking natural enamel formation. When applied to artificially created early enamel lesions (white spot lesions), the keratin-based system was able to repair the damage, restoring both the tooth's optical appearance and its mechanical properties. Notably, the mechanical recovery was significant; nanoindentation tests showed the elastic modulus of damaged enamel increased from ~5 GPa back to ~53 GPa, and hardness recovered from ~0.1 GPa to over 1.0 GPa after treatment. These findings present a promising, simple, and potentially low-cost strategy for the clinical treatment of early dental caries. Disclaimers:• This information is for educational purposes only and should not be interpreted as medical or dental advice.• The study discussed was conducted in vitro (on extracted human teeth in a laboratory setting). Further research and human clinical trials are necessary to confirm these findings and evaluate safety and efficacy.• Always consult with a qualified dental professional before making any changes to your oral healthcare routine or treatment plan.• This channel does not provide medical advice.#Keratin #EnamelRegeneration #Biomineralization #DentalResearch #RegenerativeDentistryS. Gamea, E. Radvar, D. Athanasiadou, et al. “ Biomimetic Mineralization of Keratin Scaffolds for Enamel Regeneration.” Adv. Healthcare Mater. (2025): e02465. https://doi.org/10.1002/adhm.202502465Alchepharma,Ralph Turchiano,citation,research,study,Keratin,enamel regeneration,biomimetic mineralization,apatite nanocrystals,hard tissue regeneration,dental caries,white spot lesion repair,protein scaffolds,self-assembly,spherulites,nanoindentation,Knoop microhardness,tooth decay treatment,regenerative dentistry,biomaterials,apatite nucleation,hierarchical structure,dental tissue engineering,keratin films,in vitro study,restorative dentistry,tooth repair

A study in the journal Nature has uncovered a significant link between the brain's natural lithium levels and Alzheimer's disease (AD). After analyzing 27 different metals in post-mortem human brain tissue, researchers found lithium was the only one significantly reduced in individuals with both mild cognitive impairment (MCI) and AD. The research also showed that amyloid-β plaques, a key marker of AD, trap lithium, which further lowers its availability for use by brain cells.To confirm this link, scientists conducted experiments on mouse models. They found that reducing the brain's lithium levels by roughly 50% caused an acceleration of AD-like pathology, including increased amyloid-β and phospho-tau deposits, greater neuroinflammation, and a more rapid decline in cognitive function. These effects appear to be driven, at least in part, by the over-activity of a kinase known as GSK3β.As a potential therapeutic strategy, the team tested a specific salt, lithium orotate (LiO), which is less likely to be sequestered by amyloid plaques. In AD mouse models, low-dose treatment with LiO successfully prevented memory loss and the accumulation of amyloid and tau pathology. The therapy was highly effective, reducing the Aβ plaque burden by about 70% in one model. Furthermore, LiO even reversed age-related memory decline in normal aging mice, pointing to a broader role for lithium in maintaining cognitive health. The findings suggest that a disruption of lithium balance may be a treatable early event in the development of Alzheimer's disease.Disclaimers"This information is for educational purposes only and should not be interpreted as medical advice.""The study discussed was conducted on human post-mortem brain samples and mouse models. Further research may be needed to confirm these findings in human clinical trials.""Always consult with a qualified healthcare professional before making any changes to your diet, supplement regimen, or treatment plan, especially if you have a medical condition or are taking medications. Lithium can be toxic at high doses and should only be used under medical supervision.""This channel does not provide medical advice."#Lithium #AlzheimersDisease #NeuroscienceResearch #CognitiveHealth #LithiumOrotateAron, L., Ngian, Z.K., Qiu, C., et al. "Lithium deficiency and the onset of Alzheimer's disease." Nature (2025).

A recent network meta-analysis published in the journal Nutrients systematically compared the effectiveness of seven common nutritional supplements for treating knee osteoarthritis (KOA). The analysis included 39 randomized controlled trials (RCTs) with a total of 4,599 patients. Researchers evaluated the impact of eggshell membrane, vitamin D, Boswellia, curcumin, ginger, krill oil, and collagen against a placebo for improving pain, stiffness, and function. The results showed that compared to a placebo, Boswellia provided statistically significant improvements across all measures, including WOMAC pain (mean difference [MD] = -10.58), stiffness (MD = -9.47), function (MD = -14.00), and VAS pain (MD = -17.26). Bayesian analysis consistently ranked Boswellia as the most likely to be the best option for pain and stiffness relief. Other supplements also showed benefits; krill oil, curcumin, and collagen significantly improved function, while collagen, curcumin, and ginger significantly reduced VAS pain scores. Importantly, no supplement was associated with an increase in adverse events compared to the placebo. The authors conclude that certain supplements, particularly Boswellia, appear to be effective and well-tolerated for managing KOA symptoms.Disclaimers:• "This information is for educational purposes only and should not be interpreted as medical advice." • "The study discussed is a network meta-analysis of randomized controlled trials conducted on humans. Further research may be needed to confirm these findings." • "Always consult with a qualified healthcare professional before making any changes to your diet, supplement regimen, or treatment plan, especially if you have a medical condition or are taking medications." #Boswellia #Curcumin #Collagen #KrillOil #GingerZhang Y, Gui Y, Adams R, Farragher J, Itsiopoulos C, Bow K, Cai M, Han J. Comparative Effectiveness of Nutritional Supplements in the Treatment of Knee Osteoarthritis: A Network Meta-Analysis. Nutrients. 2025; 17(15):2547. https://doi.org/10.3390/nu17152547Alchepharma,Ralph Turchiano,citation,research,study,Knee osteoarthritis,nutritional supplements,Boswellia,curcumin,collagen,ginger,krill oil,eggshell membrane,vitamin D,network meta-analysis,randomized controlled trials,WOMAC pain,WOMAC stiffness,WOMAC function,VAS pain,joint pain relief,osteoarthritis treatment,supplement efficacy,anti-inflammatory supplements

Vitamin A5 is a fascinating "new" vitamin that acts as a vital key in your body. It helps activate something called the Retinoid X Receptor (RXR), which is like a central control panel or "master switch" for many important functions. This crucial vitamin comes from certain foods, especially leafy green vegetables. Research suggests that many people in Western countries aren't consuming enough of these foods, leading to a potential Vitamin A5 deficiency. This lack could be a contributing factor to the rising rates of poor mental health and neurological issues. By making sure you get enough Vitamin A5 through your diet, you're essentially providing your body with the right tool to keep these vital systems running smoothly, offering a plausible explanation for why a diet rich in vegetables is so protective against many common diseases.Disclaimers"This video shares information for learning only and isn't medical advice." "The science on Vitamin A5 is still growing, and we need more studies in people to fully understand all its effects, especially on the brain.""Always talk to your doctor or a health expert before changing your diet or taking any new supplements, especially if you have health concerns or take medications." "This channel does not make money from videos and does not give medical advice."#VitaminA5 #BrainHealth #HealthyEating #MentalWellness #EatYourGreensBohn T, Rohn S, Böhm V, Despotovic M, de Lera AR, Krezel W, Kucuk O, Bánáti D, Rühl R. Vitamin A5: Evidence, Definitions, Gaps, and Future Directions. Nutrients. 2025; 17(14):2317. https://doi.org/10.3390/nu17142317Alchepharma,Ralph Turchiano,citation,research,study,Vitamin A5 benefits,new vitamin discovery,leafy greens brain,healthy diet mental health,RXR activation,retinoid X receptor,neurodegenerative disease prevention,cognitive function diet,what is Vitamin A5,natural brain boost,dietary supplements science,mental clarity food,immune system vitamin,cellular differentiation,chronic disease diet,carotenoids health,future of vitamins,9-cis-beta-carotene

A randomized, double-blind, placebo-controlled trial investigated the sleep-promoting effects of Heukharang lettuce (Lactuca sativa L.) extract in Korean adults aged 30-65 with poor sleep quality (Pittsburgh Sleep Quality Index (PSQI) score > 5). Over four weeks, participants received two capsules daily of either the test extract or a placebo. The study found that the test group showed a greater improvement in global PSQI scores compared to the placebo group (6.48 ± 0.63 vs. 7.41 ± 0.57, p=0.0462). Objective measurements from actigraphy revealed significant improvements in total sleep time (TST) (421.68 ± 13.29 min vs. 386.57 ± 12.27 min, p=0.0023) and sleep efficiency (SE) (83.90 ± 1.60% vs. 81.01 ± 1.50%, p=0.0342) in the test group. Polysomnography (PSG) results also favored the test group, demonstrating higher TST (358.90 ± 19.75 min vs. 322.11 ± 17.66 min, p=0.0457), higher SE (86.86 ± 3.31% vs. 79.60 ± 2.99%, p=0.0182), and lower wake after sleep onset (WASO) (39.26 ± 10.57 min vs. 68.15 ± 9.60 min, p=0.0042). These findings suggest that Heukharang extract can enhance both sleep quality and quantity and is considered safe, indicating its potential as a functional food for improving sleep.3. Disclaimers:• This information is for educational purposes only and should not be interpreted as medical advice.• The study discussed was conducted on Korean adults aged 30-65 with poor sleep quality. Further research may be needed to confirm these findings in other populations.• Always consult with a qualified healthcare professional before making any changes to your diet, supplement regimen, or treatment plan, especially if you have a medical condition or are taking medications.• This channel is not monetized and does not provide medical advice.• (Remember to include a verbal disclaimer in the video itself.)#LettuceSleep #HeukharangExtract #SleepQualityImprovement #SleepResearch #FunctionalFoodSon K, Lee M, Bok MK, Hwang KJ, Lim H. Sleep Promoting Effects of Lettuce (Lactuca sativa L.) Extracts in Korean Adults with Poor Sleep Quality: A Randomized, Double-Blind Placebo-Controlled Trial. Nutrients. 2025; 17(13):2172. https://doi.org/10.3390/nu17132172Alchepharma,Ralph Turchiano,citation,research,study,Pittsburgh Sleep Quality Index (PSQI),total sleep time (TST),sleep efficiency (SE),wake after sleep onset (WASO),Heukharang extract efficacy,sleep disorder natural remedies,sesquiterpene lactones (BSLs),lactucin sleep,lactucopicrin sleep,GABA receptors sleep,subjective sleep quality assessment,objective sleep measures,Korean adults health,sleep duration improvement,non-pharmacological sleep aids

A recent study published in LabMed Discovery investigated the effectiveness of a vitamin D3-loaded nanoemulsion in improving core manifestations of autism spectrum disorder (ASD) in children, compared to a widely available vitamin D3 product. The research involved 80 children with ASD, aged 3 to 6 years, divided into two groups over six months. Group I received an oral vitamin D3-loaded nanoemulsion, while Group II received a marketed oral vitamin D3 product.Results showed that supplementation with the vitamin D3-loaded nanoemulsion in Group I led to significant elevations in both 25(OH) and 1,25(OH)2 forms of vitamin D3 (P < 0.0001). This group also experienced behavioral improvements, including a reduction in ASD severity (P = 0.0002), an increase in social IQ (P = 0.04), and a rise in total language age (P = 0.0009). In contrast, Group II, receiving the marketed vitamin D3 product, did not show significant adaptive behavioral improvements, despite elevated vitamin D3 levels. The study concludes that the vitamin D3-loaded nanoemulsion offered superior bioavailability and a tangible positive influence on ASD severity, adaptive behavior, fine motor abilities, and language performance.3. Disclaimers:"This information is for educational purposes only and should not be interpreted as medical advice.""The study discussed was conducted on human participants (children with ASD). While promising, further research may be needed to confirm these findings across broader populations.""Always consult with a qualified healthcare professional before making any changes to your diet, supplement regimen, or treatment plan, especially if you have a medical condition or are taking medications.""This channel does not provide medical advice."#AutismResearch #VitaminD3Nanoemulsion #ASDTreatment #Neurodevelopment #ChildhoodAutismStudy Citation:Meguid, N. A., et al. (2025). Improved core manifestations of autism following supplementation with vitamin D3-loaded nanoemulsion. LabMed Discovery. doi.org/10.1016/j.lmd.2025.100071.Alchepharma,Ralph Turchiano,Autism spectrum disorder,vitamin D3 nanoemulsion,core manifestations autism,language performance autism,social IQ autism,adaptive behavior ASD,vitamin D bioavailability,ASD intervention,childhood autism rating scale,Vineland adaptive behavior scale,preschool language scale,25-hydroxycholecalciferol,25-dihydroxycholecalciferol,vitamin D deficiency autism,clinical trial vitamin D,cognitive function autism,motor skills autism

A recent systematic review in the journal Nutrients analyzed 146 studies to evaluate the safety and efficacy of glucosamine and chondroitin in humans. Researchers found that for conditions like osteoarthritis and joint pain, the supplements are generally effective and well-tolerated. Over 90% of the efficacy studies included in the review reported positive outcomes for patients. Similarly, a majority of safety studies (80 out of 107) concluded that the supplements have minimal to no adverse effects, with the most common being mild gastrointestinal complaints. The most frequently studied and effective daily dosages were 1500 mg for glucosamine and 1200 mg for chondroitin, typically taken together in two or three divided doses.Disclaimers:"This information is for educational purposes only and should not be interpreted as medical advice.""The information presented is from a systematic review of 146 human studies, the majority of which were randomized controlled trials.""Always consult with a qualified healthcare professional before making any changes to your diet, supplement regimen, or treatment plan, especially if you have a medical condition or are taking medications.""This channel does not provide medical advice."#Glucosamine #Chondroitin #Osteoarthritis #JointPain #SystematicReviewBaden KER, Hoeksema SL, Gibson N, Gadi DN, Craig E, Draime JA, Tubb SM, Chen AMH. The Safety and Efficacy of Glucosamine and/or Chondroitin in Humans: A Systematic Review. Nutrients. 2025; 17(13):2093. https://doi.org/10.3390/nu17132093Glucosamine, Chondroitin, Glucosamine Chondroitin, Osteoarthritis, Joint Pain, Knee Osteoarthritis, Hip Osteoarthritis, Temporomandibular Disorder, Cartilage, Joint Health, Supplement Efficacy, Supplement Safety, WOMAC score, Lequesne Index, Visual Analog Scale, Joint Pain Relief, Anti-inflammatory supplements, Systematic Review, Human Studies, Clinical Trial, Glucosamine d

A recent 6-month study looked at whether taking hawthorn fruit (HF) supplements could improve facial skin and a biological marker of aging called telomere length. They had 36 adults, aged 25 to 75, participate, with some taking a hawthorn fruit powder supplement (900 mg/day) and others taking a dummy pill (placebo). The exciting news is that the group taking hawthorn fruit saw a significant boost in their skin's hydration (how moist and plump it was) compared to the placebo group. Specifically, the hawthorn group's hydration scores went up by 1.71 points on average, while the placebo group's went down by 3.00 points. While there wasn't a big change in overall telomere length, the study found that the improvements in skin hydration were particularly noticeable in people with a specific genetic makeup (those with the "CC" genotype of rs7705526). What's more, the hawthorn group also saw a reduction in wrinkles, while the control group's wrinkles actually increased, especially for those with another specific genetic makeup (the "AA" genotype of rs2853669). These results suggest that adding hawthorn fruit to your routine might help fight skin aging, and it might even work better for some people depending on their genes. Disclaimers:"This information is just for learning and shouldn't be taken as medical advice.""This study was done on adults. More research might be needed to see if these results apply to everyone or if different amounts of hawthorn fruit would have the same effect." "Always talk to a doctor or healthcare professional before changing your diet, taking new supplements, or changing any treatment plans, especially if you have health issues or are on medication.""This channel isn't monetized, and we don't give medical advice." (Remember to say these disclaimers in your video.)Hashtags:#HawthornForSkin #YouthfulSkin #NaturalBeauty #SkinScience #HealthyAgingKim M, Baik I. Effects of Hawthorn Fruit Supplementation on Facial Skin Phenotypes and Leukocyte Telomere Length Stratified by TERT Polymorphisms. Nutrients. 2025; 17(12):1983. https://doi.org/10.3390/nu17121983Search Terms:Alchepharma,Ralph Turchiano,citation,research,study,Hawthorn skin benefits,younger looking skin,natural wrinkle reduction,anti-aging supplements,hawthorn fruit extract skin,healthy skin diet,genetic factors skin aging,telomeres and skin,what helps wrinkles,best supplements for skin,clear skin tips,natural remedies for dry skin,hawthorn berries benefits,skin health research,how to get glowing skin,research on natural anti-aging,improve skin elasticity

The Liver & Weight Connection: New Curcumin Research Ep. 1246 JUN 2025SummaryA 12-month, double-blind, placebo-controlled trial has revealed that daily supplementation with 1500 mg of curcumin offers significant benefits for both liver health and weight management in individuals with Type 2 Diabetes and Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). The study demonstrated remarkable improvements in liver health markers for the curcumin group compared to the placebo group. Specifically, after 12 months, participants taking curcumin had significantly lower liver stiffness (4.2 kPa vs 6.9 kPa) and significantly less liver fat, as measured by the Controlled Attenuation Parameter (223 dB/m vs 292 dB/m). Fatty liver-associated indicators such as the Fatty Liver Index (FLI) and Hepatic Steatosis Index (HSI) also showed significant reductions.In addition to these direct liver benefits, the curcumin group also experienced significant improvements in body composition. Body Mass Index (BMI) was significantly reduced from the 6-month mark onward. At the end of the study, the median BMI for the curcumin group was 25.97 kg/m², notably lower than the placebo group's 27.70 kg/m². Furthermore, significant decreases in total body fat and waist circumference were observed. The researchers suggest that curcumin's anti-inflammatory and antioxidant properties may underlie these combined benefits, making it a promising adjunctive therapy for managing both liver health and weight.DisclaimersThis information is for educational purposes only and should not be interpreted as medical advice. The study discussed was conducted on humans with Type 2 Diabetes and MASLD. Further research may be needed to confirm these findings in other populations.Always consult with a qualified healthcare professional before making any changes to your diet, supplement regimen, or treatment plan, especially if you have a medical condition or are taking medications. This channel does not provide medical advice. #Curcumin #LiverHealth #WeightLoss #MASLD #BMIYaikwawong M, Jansarikit L, Jirawatnotai S, Chuengsamarn S. Curcumin for Inflammation Control in Individuals with Type 2 Diabetes Mellitus and Metabolic Dysfunction-Associated Steatotic Liver Disease: A Randomized Controlled Trial. Nutrients. 2025; 17(12):1972. https://doi.org/10.3390/nu17121972Alchepharma,Ralph Turchiano,citation,research,study,Curcumin liver health,Curcumin weight loss,MASLD treatment,hepatic steatosis curcumin,curcumin liver stiffness,curcumin BMI reduction,fatty liver index,FibroScan curcumin,supplements for liver fat,curcumin body fat,clinical trial curcumin liver,antioxidant supplements liver,non-alcoholic fatty liver disease,weight management supplements,liver enzyme improvement,curcumin for metabolic syndrome

This video explores the significant potential of bergamot, particularly its Bergamot Polyphenolic Fraction (BPF), in managing cholesterol levels, based on a review in Nutrients. Bergamot primarily lowers cholesterol by inhibiting HMG-CoA reductase, the same enzyme targeted by statins, with compounds like brutieridin and melitidin playing a key role ; in vitro studies have shown up to a 30-40% reduction in cholesterol synthesis in liver cells. Clinical trials demonstrate notable LDL-C reductions, for example, 500 mg/day of BPF decreased LDL-C by 24.1% in 30 days , while 1000 mg/day lowered LDL-C by 40.8%. Doses up to 1300 mg/day have resulted in LDL-C reductions of 37.7% over 120 days in patients with metabolic syndrome.Regarding safety, bergamot has generally been well-tolerated in human trials lasting up to 120 days, with no significant adverse effects reported. Animal studies also indicate a good safety profile, with doses up to 150 mg/kg/day of BPF showing no liver, kidney, or blood toxicity. Even in statin-intolerant patients, 1500 mg/day of bergamot extract showed favorable results without adverse effects in one study. However, it's important to note that data on long-term safety and use at higher doses are still limited. Caution is advised for individuals on multiple medications due to the potential for drug-nutraceutical interactions, which are not yet fully understood.Disclaimers:"This information is for educational purposes only and should not be interpreted as medical advice.""The review discusses findings from preclinical studies and clinical trials. While short-term human studies (up to 120 days) suggest bergamot is generally well-tolerated , comprehensive long-term safety data, especially at higher doses, is still emerging. The effects of bergamot can vary based on the individual, the formulation, and dosage.""Always consult with a qualified healthcare professional before making any changes to your diet, supplement regimen, or treatment plan, particularly if you have a medical condition, are taking medications (especially for cholesterol or other cardiovascular issues), or are considering bergamot supplementation. Discuss potential interactions if you are on polypharmacy.""This channel does not provide medical advice."#BergamotCholesterol #NutraceuticalSafety #LipidManagement #HeartHealthSupplements #BergamotCarpenito M, Coletti F, Muscoli S, Guarino L, Di Cristo A, Cammalleri V, Mega S, Emerenziani S, Cicala M, Fanali C, et al. Unveiling the Power of Bergamot: Beyond Lipid-Lowering Effects. Nutrients. 2025; 17(11):1871. https://doi.org/10.3390/nu17111871Alchepharma,Ralph Turchiano,Bergamot cholesterol reduction,bergamot safety profile,bergamot side effects,bergamot HMG-CoA reductase,bergamot triglycerides,bergamot clinical trials cholesterol,safe cholesterol supplements,natural cholesterol lowering,bergamot long-term use,bergamot dosage for cholesterol,bergamot vascular benefits,bergamot antioxidant heart,bergamot and statins,small dense LDL reduction,dyslipidemia nutraceuticals,bergamot mechanisms of action

Vitamin D Slows Biological Aging? New 4-Year Study on Telomeres! Ep. 1244 JUN 2025A recent sub-study of the large-scale VITamin D and OmegA-3 TriaL (VITAL), published in The American Journal of Clinical Nutrition, has revealed significant findings regarding vitamin D and cellular aging. Researchers analyzed leukocyte telomere length (LTL) in 1,054 participants over four years. The results showed that daily supplementation with 2,000 IU of vitamin D3 significantly reduced telomere shortening compared to a placebo. Specifically, vitamin D3 supplementation decreased LTL attrition by 0.14 kilobase pairs over the four years (p=0.039), an effect described as equivalent to preventing nearly three years of biological aging. This is the first large-scale, long-term randomized trial to show this protective effect on telomeres, which are caps at the ends of chromosomes linked to aging. Interestingly, marine omega-3 fatty acid supplementation did not show a significant effect on telomere length in this sub-study. These findings add to previous VITAL results showing vitamin D's role in reducing inflammation and risks of certain age-related diseases.Disclaimers:"This information is for educational purposes only and should not be interpreted as medical advice.""The study discussed was conducted on U.S. females aged 55 years and older and males aged 50 years and older. Findings may not apply to other populations.""Always consult with a qualified healthcare professional before making any changes to your diet, supplement regimen, or treatment plan, especially if you have a medical condition or are taking medications. Do not exceed recommended dosages of Vitamin D without medical supervision.""This channel does not provide medical advice."#VitaminD #Telomeres #AntiAgingResearch #VITALStudy #CellularHealthHaidong Zhu, JoAnn E. Manson, Nancy R. Cook, Bayu B. Bekele, Li Chen, Kevin J. Kane, Ying Huang, Wenjun Li, William Christen, I-Min Lee, Yanbin Dong. Vitamin D3 and Marine Omega-3 Fatty Acids Supplementation and Leukocyte Telomere Length: 4-Year Findings from the VITAL Randomized Controlled Trial. The American Journal of Clinical Nutrition, 2025; DOI: 10.1016/j.ajcnut.2025.05.003Alchepharma,Ralph Turchiano,citation,research,study,Vitamin D3 supplementation,leukocyte telomere length,LTL attrition,VITAL trial,biological aging,cellular aging,chromosome protection,anti-aging supplements,vitamin D benefits,telomere shortening reduction,2000 IU vitamin D,chronic disease prevention,inflammation reduction,advanced cancer risk,autoimmune disease risk,Mass General Brigham,genetic aging markers,DNA protection,long-term vitamin D effects

A recent randomized, double-blind, crossover trial published in Nutrients investigated the effects of short-term beetroot juice (BJ) supplementation on resistance-trained males. Eleven healthy men (average age 21.3±1.9 years) consumed either beetroot juice, providing 450 mg of nitrate per day, or a nitrate-free placebo. The study found that BJ supplementation significantly enhanced high-intensity resistance performance. Specifically, participants completed more repetitions at 80% of their one-repetition maximum (1RM) in both bench press and back squat exercises when taking beetroot juice compared to the placebo. Peak movement velocity also improved across all tested intensities (60-80% 1RM) with BJ supplementation. Furthermore, beetroot juice led to higher muscle oxygenation (SmO2 ) particularly at 70-80% 1RM and this effect was even more pronounced after 72 hours of supplementation. The study also noted reduced cardiovascular strain, evidenced by lower peak heart rates during exercise with BJ. Post-exercise recovery favored beetroot juice, with participants showing faster recovery in jump performance (both countermovement and squat jumps) at 24 hours and experiencing reduced upper-limb delayed-onset muscle soreness (DOMS) at 24-48 hours. These findings suggest that short-term BJ supplementation can be a practical strategy for physically active individuals looking to optimize training performance and accelerate recovery.Disclaimers:"This information is for educational purposes only and should not be interpreted as medical advice.""The study discussed was conducted on healthy, physically active young men. Further research may be needed to confirm these findings in other populations, including women, older adults, or individuals with medical conditions.""Always consult with a qualified healthcare professional before making any changes to your diet, supplement regimen, or treatment plan, especially if you have a medical condition or are taking medications.""This channel does not provide medical advice."#BeetrootJuice #NitrateSupplementation #ResistanceTraining #ExercisePerformance #MuscleRecoverySalem A, Ammar A, Kerkeni M, Boujelbane MA, Uyar AM, Köbel LM, Selvaraj S, Zare R, Heinrich KM, Jahrami H, et al. Short-Term Beetroot Juice Supplementation Enhances Strength, Reduces Fatigue, and Promotes Recovery in Physically Active Individuals: A Randomized, Double-Blind, Crossover Trial. Nutrients. 2025; 17(10):1720. https://doi.org/10.3390/nu17101720

A recent study in mice explored how a combination of two supplements, lactoferrin and creatine, might help with age-related muscle loss, a condition called sarcopenia. Scientists induced sarcopenia in mice, causing their muscle mass and function to decline. For 8 weeks, these mice were given lactoferrin, creatine, or a mixture of both. The results were promising: the group of mice receiving both lactoferrin and creatine showed the most significant improvements. For example, the lean body content in the sarcopenia model group dropped to around 47-48%, while the group receiving the combination treatment saw their lean body content increase to about 51-52%, bringing them above the levels of the healthy control group (around 50%). In terms of muscle function, the combination group's endurance on a treadmill test was approximately 1200 seconds, a significant improvement compared to the sarcopenia model group (around 600 seconds) and even surpassing the healthy control group (around 900 seconds). Their grip strength also increased to roughly 180g with the combination, compared to about 130g in the model group and 150g in controls. These findings suggest that combining lactoferrin and creatine could be a beneficial nutritional strategy to combat muscle decay associated with aging, potentially by improving how muscles use energy and build protein. 3. Disclaimers:• "This information is for educational purposes only and should not be interpreted as medical advice."• "The study discussed was conducted on mice. Further research is needed to confirm these findings in humans."• "Always consult with a qualified healthcare professional before making any changes to your diet, supplement regimen, or treatment plan, especially if you have a medical condition or are taking medications."• "This Channel does not provide medical advice."#Sarcopenia #MuscleHealth #Lactoferrin #Creatine #AgingWellWu W, Guo X, Qu T, Huang Y, Tao J, He J, Wang X, Luo J, An P, Zhu Y, et al. The Combination of Lactoferrin and Creatine Ameliorates Muscle Decay in a Sarcopenia Murine Model. Nutrients. 2024; 16(12):1958. https://doi.org/10.3390/nu16121958Sarcopenia, creatine, lactoferrin, muscle mass, muscle function, aging, muscle decay, D-galactose, C57BL/6 mice, muscle strength, endurance, grip strength, lean body mass, nutritional intervention, muscle protein synthesis, energy metabolism, myogenic factors, RNA-seq, mTOR signaling, PI3K-Akt signaling, longevity regulating pathway, muscle atrophy, animal model, skeletal muscle, nutritional supplements

Monk Fruit Extract: Zero-Calorie Sweetener, Surprising Benefits? Ep. 1241 MAY 2025A recent PRISMA-guided systematic review published in Nutrients synthesized findings from randomized controlled trials (RCTs) to assess the impact of monk fruit extract (MFE) on metabolic health, lipid profiles, inflammation, and regulatory considerations. The review included a number of RCTs (note: while some search results indicated 10, others mentioned 5 included studies; refer to the final published article for the definitive number). The findings indicate that MFE may help reduce postprandial glucose levels (by 10–18% in included studies) and insulin responses (by 12–22%). Some studies also reported reductions in inflammatory markers such as IL-6 and TNF-α. No severe adverse effects were observed in the reviewed trials. The review also notes that MFE is approved for use in the United States and China, with its status under review in the European Union. The authors suggest MFE shows potential as a functional food ingredient for metabolic health, though they highlight the need for long-term clinical trials and a harmonized regulatory framework to confirm its long-term safety and efficacy within sustainable health strategies. Disclaimers:"This information is for educational purposes only and should not be interpreted as medical advice.""This video discusses a systematic review of randomized controlled trials. While this represents a high level of evidence, individual results may vary, and further research is always ongoing.""Always consult with a qualified healthcare professional before making any changes to your diet, supplement regimen, or treatment plan, especially if you have a medical condition or are taking medications.""This channel does not provide medical advice."#MonkFruitExtract #MetabolicHealth #SystematicReview #RandomizedControlledTrials #SustainableHealthKaim U, Labus K. Monk Fruit Extract and Sustainable Health: A PRISMA-Guided Systematic Review of Randomized Controlled Trials. Nutrients. 2025; 17(9):1433. https://doi.org/10.3390/nu17091433Alchepharma,Ralph Turchiano,citation,research,study,Monk fruit extract,Siraitia grosvenorii,mogrosides,metabolic health,glycemic control,insulin response,inflammation,blood glucose,type 2 diabetes,natural sweeteners,low-calorie sweeteners,functional foods,dietary supplements,clinical trials,systematic review,PRISMA,nutritional science,dietary interventions,sugar substitutes,glucose metabolism,insulin sensitivity,inflammatory markers,regulatory status

Unlock the science behind Ashwagandha and stress! A pivotal 2023 systematic review published in Nutrients meticulously analyzed the current evidence on Withania somnifera's effect on the primary stress hormone, cortisol. By synthesizing data from nine clinical studies involving stressed human subjects, researchers investigated Ashwagandha's potential to modulate the hypothalamic-pituitary-adrenal (HPA) axis. The compelling finding? Supplementation with Ashwagandha for periods ranging from 30 to 112 days was consistently associated with significant reductions in cortisol levels, ranging from 11% to as much as 32.6%, compared to placebo groups. This review strongly suggests that short-term Ashwagandha use holds promise for buffering the physiological stress response in humans. However, the authors caution that dosages and formulations varied, and the long-term effects on adrenal function require further investigation.3. Disclaimers:"This information is for educational purposes only and should not be interpreted as medical advice.""This video discusses findings from a systematic review of studies conducted on stressed human subjects over short durations (30-112 days). Individual results can vary significantly based on dosage, formulation, duration of use, and individual health status. Long-term effects are not well established.""Always consult with a qualified healthcare professional before making any changes to your diet, supplement regimen, or treatment plan, especially if you have a medical condition (like thyroid disorders, autoimmune diseases, or hormone-sensitive conditions), are pregnant or breastfeeding, or are taking medications (such as immunosuppressants, sedatives, thyroid hormone, or medications for diabetes or high blood pressure).""This channel does not provide medical advice."#Ashwagandha #Cortisol #StressResponse #SystematicReview #AdaptogensDella Porta M, Maier JA, Cazzola R. Effects of Withania somnifera on Cortisol Levels in Stressed Human Subjects: A Systematic Review. Nutrients. 2023; 15(24):5015.