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Drs. Spencer and Karl Nadolsky talk about nutrition, medicine, and fitness through the lens of two physicians who lift weights. Both doctors are former NCAA division 1 wrestlers who have gone into medicine. Dr. Spencer Nadolsky is a board certified family physician specialized in obesity medicine and lipidology. Dr. Karl Nadolsky is a board certified endocrinologist also specialized in obesity medicine.
107 Episodes
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Drs. Karl and Spencer discuss the concept of "microdosing" GLP-1 receptor agonists along with talk about the new top line results from REDEFINE which studied the new drug CagriSema.
Drs. Karl and Spencer chat with Dr. Lauren Colenso-Semple all about how the menstrual cycle and how it should affect your workout programming. Should you change your workouts around your menstrual cycle? Find out by listening! Check out her instagramRead her paper on exercise and menstrual cyclesRead her paper on protein synthesis throughout the menstrual cycle
Drs. Karl and Spencer discuss the topline results from Surmount 5 which put Zepbound (tirzepatide) against Wegovy (semaglutide) for weight loss. They also discuss some news around compounded GLP-1s.Learn:Weight loss and glycemic differences between tirzepatide and semaglutideWhat the FDA is thinking for compounded GLP-1sIf you're not on Dr. Spencer's virtual clinic waitlist, click here
Drs. Karl and Spencer chat with Dr. Shivani Misra, a metabolic specialist physician researcher from the UK, all about the various forms of diabetes mellitus.Learn:The types of diabetes mellitusThe monogenic forms (some what refer to as MODY)The differences within type 2 diabetesWhether CGMs (continuous glucose monitors) are usefulIf low carb could help someFollow Dr. Misra on X/Twitter
Drs. Karl and Spencer chat with AtlasMD - Dr. Josh Umbehr all about making healthcare cheaper using direct primary care.Learn:How cheap labs and and meds should beHow cutting out the middlemen can help healthcare and decrease costsFind AtlasMD here
Drs. Karl and Spencer discuss the brand new 3 year study of tirzepatide in those with prediabetes along with a discussion on semaglutide treating osteoarthritis.Learn:If people lose weight and keep it off with tirzepatideHow many people regain weight after stopping the medicineLong-term side effectsIf semaglutide helps with osteoarthritisClick here to read the tirzepatide studyClick here to read the semaglutide study
Drs. Karl and Spencer invite Dr. Andrea Love back to the podcast to discuss a recent Joe Rogan podcast with Calley and Casey Means along with the concept of Make America Healthy Again and RFK jr.Learn:What the docs agree with.What they don't agree with.Is raw milk okay?Are cancer rates rising?and moreFollow Dr. Andrea here https://www.instagram.com/dr.andrealove
Drs. Karl and Spencer discuss all things cortisol and poke fun at the influencers who try to fear monger exercise due to cortisol increases.Learn:What is cortisol and what does it do?Is cortisol bad?Should you worry about cortisol increases with exercise?Should you take supplements to lower cortisol?and more
Drs. Karl and Spencer discuss their ideal healthcare delivery system.Learn:Spencer's journey building and selling Sequence and what he wants to do next.How Dr. Karl believes healthcare should be and what he's doing next.Click here to get on Dr. Spencer's waitlist
Drs. Karl and Spencer discuss BS supplements claiming to be like Ozempic along with discuss some new obesity drugs coming down the pipeline that were announced in phase 1 and 2 trials.Are there any supplements that can mimic Ozempic?What is amylin and how does it help with weight and sugars?What is this new oral drug "amycretin" in phase 1 trials?and more
Drs. Karl and Spencer chat with Dr. Jen Gunter all about menopause.Learn:How it's diagnosed.When and when not to treat.The various treatment.If it is indicated for cardiovascular disease prevention or body composition.Whether or not you should get labs.See more at Dr. Gunter's website
Drs. Karl and Spencer talk about the top line results from study showing liraglutide may have some benefit in Alzheimer's along with top line results from the Summit trial showing heart failure benefits with tirzepatide.They also discuss the women's boxing controversy and BMI in athletes.
Drs. Karl and Spencer chat with return guest and bone expert endocrinologist Dr. Rachel Pessah-Pollack all about the new Vitamin D guidelines.Should healthy people even check a vitamin D level?Should they supplement with vitamin D?What people should check or supplement?Click here for the new guidelines
Does semaglutide cause blindness?What is NAION (nonarteritic anterio ischemic optic neuropathy)?What about worsening of diabetic retinopathy with semaglutide?What can you do to minimize the risk of NAION and retinopathy?Get the full study hereRead Dr. Brugger's blog
Tirzepatide may be a good option if you have obesity and obstructive sleep apnea.Click here to read the study
Click here to read about the gastric ablation and trial.Click here to see Dr. McGowan's clinic
Drs. Karl and Spencer discuss the recent FLOW trial where semaglutide was found to be kidney protective. They also go off about the costs of these medicines and what to do (including compounding considerations).
Click here to see the study
Drs. Karl and Spencer discuss the most recent South Park episode where GLP-1 medicines are discussed along with the dysfunctions of our healthcare system among other issues.
Drs. Karl and Spencer discuss the fallacies of functional medicine.
You'll learn what functional medicine is and whether you should seek it out.
Drs. Karl and Spencer respond to Jillian Michaels on the Bill Maher show
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