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Howie and Harlan react to President Joe Biden’s declaration that the pandemic is over. Then they’re joined by Jonathan Rothberg, a Yale-trained scientist who has created new methods for sequencing DNA and founded a series of successful biotech companies. Disclosure: Harlan Krumholz is a consultant to Tesseract, a portfolio company of 4 Catalyzer, which was founded by Jonathan Rothberg. Links: “Biden: ‘The pandemic is over’” Eric Topol: “To boost or not to boost” “An integrated semiconductor device enabling non-optical genome sequencing” ”Butterfly Network Distributes 500 Butterfly iQ+ Devices to Healthcare Workers in Kenya to Transform Maternal and Fetal Health” ”AI Estimation of Gestational Age from Blind Ultrasound Sweeps in Low-Resource Settings” Butterfly Network Protein Evolution Hyperfine ”Uncovered Medical Bills after Sexual Assault” Learn more about the MBA for Executives program at Yale SOM. Email Howie and Harlan comments or questions.
Howie and Harlan discuss the confusion over COVID therapeutics, even among professionals. Then they're joined by Dr. Jeremy Faust, a researcher, emergency physician, and public voice on COVID and other issues—as well as an active choral conductor. They discuss his unusual path, the state of the pandemic, and the importance of understanding “excess mortality.” Links: “Coronavirus (COVID-19) Update: FDA Authorizes New Monoclonal Antibody for Treatment of COVID-19 that Retains Activity Against Omicron Variant” Overview of Bebtelovimab COVID-19 Therapeutics Locator Jeremy Faust: Inside Medicine Robert T. Sataloff: “The Human Voice” Jeremy Faust: “Excess Mortality in Massachusetts During the Delta and Omicron Waves of COVID-19: All-Cause Excess Mortality and COVID-19–Related Mortality Among US Adults Aged 25-44 Years, March-July 2020 Longwood Symphony and World Doctors Orchestra at Symphony Hall “Out-of-pocket spending on insulin among people with private insurance” Learn more about the MBA for Executives program at Yale SOM. Email Howie and Harlan comments or questions.
Harlan outlines his new study tracking excess mortality over the course of the pandemic in the highly vaccinated state of Massachusetts; Howie discusses how the Inflation Reduction Act will tackle drug prices. They're joined by Dr. Esther Choo to talk about life as a doctor on social media and the crisis facing emergency departments. Links: Esther Choo: “Covid-19 is pushing doctors to the brink. Medicine needs to recognize they’re human and need help.” “Uncoupling of all-cause excess mortality from COVID-19 cases in a highly vaccinated state” “New York Governor Lifts Mask Mandate for NYC Subways” White House Fact Sheet: The Inflation Reduction Act Supports Workers and Families Learn more about the MBA for Executives program at Yale SOM. Learn more about the MD-MBA program at Yale. Email Howie and Harlan comments or questions.
Beating the Outbreaks

Beating the Outbreaks


Monkeypox, polio, and COVID-19 have all received the World Health Organization’s rarely used global health emergency designation. Howie and Harlan offer a needed sense of proportion alongside health information, updates on research, and policy developments for the grim trio of diseases.
Howie and Harlan talk with Dr. James Hamblin, a journalist and a lecturer at the Yale School of Public Health. They discuss his approach to communicating about public health, his prescient February 2020 article on COVID-19, and why he’s quit taking showers. Links: James Hamblin: The Body “You’re Likely to Get the Coronavirus” Learn more about the MBA for Executives program at Yale SOM. Email Howie and Harlan comments or questions.
Howie and Harlan are joined by Teresa Chahine, the Sheila and Ron ’92 B.A. Marcelo Senior Lecturer in Social Entrepreneurship at Yale SOM. They discuss how social entrepreneurs use an interdisciplinary, iterative, community-centric approach to innovation to create self-sustaining solutions to problems in public health and other areas. Links: “Tirzepatide Once Weekly for the Treatment of Obesity” Teresa Chahine: “Toward an Understanding of Public Health Entrepreneurship and Intrapreneurship” Teresa Chahine: Social Entrepreneurship: Building Impact Step by Step, 2nd Edition (December 2022) Learn more about the MBA for Executives program at Yale SOM. Email Howie and Harlan comments or questions.
Howie and Harlan discuss Harlan's large new study tracking the trajectory of patient safety in hospitals, and consider how individuals should respond to the latest COVID-19 variants. They're joined by Jennifer Miller, a Yale bioethicist and the director of the Good Pharma Scorecard, which evaluates the performance of pharmaceutical companies on measures like the transparency of clinical trials and the accessibility of medicines.  Links: “New Federal Study Evaluates the Safety of US Hospitals and the Answer Is…” “Trends in Adverse Event Rates in Hospitalized Patients, 2010-2019” Good Pharma Scorecard Learn more about the MBA for Executives program at Yale SOM. Email Howie and Harlan comments or questions.
Rethinking Research

Rethinking Research


Howie and Harlan discuss a concerning new COVID-19 variant, the discovery casting doubt on a major fish-oil study, and the need for new models of funding research. Links: “New Omicron subvariant Centaurus could be the most immune-evasive yet, expert warns” “Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia” “Effects of Randomized Treatment With Icosapent Ethyl and a Mineral Oil Comparator on Interleukin-1β, Interleukin-6, C-Reactive Protein, Oxidized Low-Density Lipoprotein Cholesterol, Homocysteine, Lipoprotein(a), and Lipoprotein-Associated Phospholipase A2: A REDUCE-IT Biomarker Substudy” Learn more about the MBA for Executives program at Yale SOM. Email Howie and Harlan comments or questions. 
Harlan reviews the latest COVID-19 research, and Howie reflects on the vast ramifications of the Dobbs decision overturning Roe v. Wade. They’re joined by Dr. Rebekah Gee, an ob-gyn and the CEO of Nest Health, which aims to deliver care to vulnerable children and their parents at home. She also describes her experience as a pro-choice physician serving as secretary of the Louisiana Department of Health. Links: Rebekah Gee discusses letters from her late mother on This American Life.  About Nest Health “The War On Abortion Could Turn The US Into A Police State” “The dynamics of SARS-CoV-2 infectivity with changes in aerosol microenvironment” Learn more about the MBA for Executives program at Yale SOM.
Howie and Harlan are joined by Yale epidemiologist and MacArthur ‘genius’ Gregg Gonsalves to discuss his non-traditional route to improving responses to global public health challenges. Links: Eric Topol on COVID reinfections Harlan’s Twitter thread on insurance debt “Health Savings Accounts No Longer Promote Consumer Cost-Consciousness” Sherry Glied in Health Affairs The Best Little Boy in the World Learn more about the MBA for Executives program at the Yale School of Management.
Harlan interviews Howie about his life as a doctor and teacher, including how a radiologist without a PhD got to teach economics at Yale, why he engages in the daily battles that come with speaking out on Twitter, and the extraordinary return on investment from time spent mentoring young people. Links: Arnold Schwarzenegger on deaths attributable to pollution “Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit” “Climate Change, Fossil-Fuel Pollution, and Children’s Health“ Merriam-Webster on the origin of the word “doctor” Learn more about the MBA for Executives program at the Yale School of Management.  
Howie and Harlan are joined by Dr. Seth Trueger of Northwestern University, who was diagnosed with a rare autoimmune disorder in 2020. They discuss his experience navigating the healthcare system as a patient and what he’s learned about the challenges facing people with complex medical issues. Links: 2022 Medicare Trustees Report  “A Cancer Trial’s Unexpected Result: Remission in Every Patient” “PD-1 Blockade in Mismatch Repair–Deficient, Locally Advanced Rectal Cancer” Seth Trueger: “The Best Bad News” “Public Finance Balance of Smoking in the Czech Republic” Learn more about the MBA for Executives program at the Yale School of Management
Harlan explains what the research says about the immunity acquired from a COVID-19 infection, and suggests a framework for thinking about exposure risk. Then Howie and Harlan are joined by Thomas Balcezak, chief clinical officer at the Yale New Haven Health System. They discuss the financial and human capital challenges faced by hospitals in the wake of the pandemic. Links: “Protection and Waning of Natural and Hybrid Immunity to SARS-CoV-2” “Medical Education in the United States and Canada” (The Flexner Report) About Yale New Haven Health “Mass General Brigham says it will reduce spending by $70m annually” “US Mass Shootings, 1982–2022: Data From Mother Jones’ Investigation”
Howie and Harlan are joined by Dr. Amy Justice, a Yale clinical epidemiologist. They discuss the influential long-running studies she has conducted using the electronic medical record from the Veterans Administration Healthcare System.  Links: Basketball coach Steve Kerr on the shooting in Uvalde, Texas The Veteran Aging Cohort Study  “Comparison of Risk and Age at Diagnosis of Myocardial Infarction, End-Stage Renal Disease, and Non-AIDS-Defining Cancer in HIV-Infected Versus Uninfected Adults”  “Covid-19 Testing, Hospital Admission, and Intensive Care Among 2,026,227 United States Veterans Aged 54–75 Years”  “At Yale, Arya Singh overcame her fears — and found a new side of herself”  Arya Singh's Class Day address  Student Spotlight: Hil Moss  Learn more about the MBA for Executives program at the Yale School of Management
Howie and Harlan are joined by Jason Schwartz of the Yale School of Public Health. They discuss what went wrong with the COVID-19 vaccine rollout and how Schwartz’s background in history and ethics informs his research on vaccine policy. Links: ”Effect of Sleep Extension on Objectively Assessed Energy Intake Among Adults With Overweight in Real-life Settings” “Effects of Experimental Sleep Restriction on Energy Intake, Energy Expenditure, and Visceral Obesity” “Impact of sleep duration on executive function and brain structure” “Mass General Brigham posts $867M quarterly net loss” Howie's Twitter exchange with Elon Musk  
Howie and Harlan are joined by Dr. Cecelia Calhoun ’21, a Yale sickle cell disease specialist and a recipient of Yale SOM's Pozen-Commonwealth Fund Fellowship in Health Equity Leadership. They discuss Calhoun's journey from growing up in Detroit to a clinical and research career focused on the health of the Black community. Links Pozen-Commonwealth Fund Fellowship in Health Equity Leadership “Heartstopper is dazzlingly brilliant TV – I wish my lonely younger self could have seen it” “The Secrets Ed Koch Carried”
Howie and Harlan are joined by Dr. Gail D’Onofrio, Yale's Albert E. Kent Professor of Emergency Medicine. They discuss the medications available for opioid addiction and the policy changes needed to allow those treatments to save more lives.  Links “Sex-Specific Risk Factors Associated With First Acute Myocardial Infarction in Young Adults” “Medication for Opioid Use Disorder After Nonfatal Opioid Overdose and Association With Mortality: A Cohort Study”
Howie and Harlan talk with Yale’s Melinda Irwin about her research investigating how lifestyle factors impact the prevention and treatment of cancer. Links “Intramuscular AZD7442 (Tixagevimab–Cilgavimab) for Prevention of Covid-19” “Neighborhood and Individual Socioeconomic Disadvantage and Survival Among Patients With Nonmetastatic Common Cancers” “Physical Activity and Health: A Report of the Surgeon General”
To do better in the next pandemic, Sherry Glied, dean of New York University’s Robert F. Wagner Graduate School of Public Service, argues we must ensure that policymakers get answers to their most pressing questions. She joins Howie and Harlan in a conversation about incentivizing relevant research and systematically synthesizing data into actionable information.
Howie and Harlan talk with NYU’s Lauren Taylor about the “dirty hands problem” and other ethical dilemmas inherent in efforts to improve health.
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