The Newcomer Podcast

On this episode of the Newcomer podcast, host Eric Newcomer is joined by co-host Nayeema Raza for conversations with some of the most influential voices in healthcare and venture capital. Bob Kocher, Partner at Venrock, and Annie Lamont, Founder and Managing Partner of Oak HC/FT, share their perspectives on business models in healthcare, the rise of AI applications, the promise and pitfalls of longevity drugs like GLP-1s, and the future of Medicare Advantage. Later, Vinod Khosla, Founder of Khosla Ventures, brings his trademark candor to a wide-ranging discussion about AI’s role in healthcare, regulatory challenges, global competition, and how startups can reimagine the system from the ground up

Journalist Nayeema Raza—host of Smart Girl Dumb Questions—joins Eric Newcomer to preview Deus Ex Medicina, their AI–health–longevity summit happening Tuesday, Sept 9 (San Francisco). They discuss the big themes going into the conference: how longevity went mainstream, why precision medicine and novel bio are finally feeling real, and who wins the race to own the patient. Eric and Nayeema get into the policy whiplash in D.C., HIPAA’s fraying edges in a wearables world, and whether or not AI will actually discover something novel, like a new drug or cure for Alzheimer's? Plus, what they’re most excited to ask on stage at Deus Ex Medicina.Timecodes:00:00 — The story behind the creation of Deus Ex Medicina08:39 — Longevity goes mainstream (the GLP-1 moment)12:42 — Precision medicine gets practical (targeted therapies & trials)17:11 — Bundles, frenemies, and who owns the patient22:31 — D.C. shake-ups, privacy stakes… and can AI invent a drug?

Former CIA officer and three-term Congressman Will Hurd joins Eric Newcomer, Tom Dotan, and Madeline Renbarger to break down Washington's defense tech boom and tackle the burning question: Is this all just hype? Hurd explains how Ukraine has changed the face of warfare and opened the door for new companies to break into the fold. However, it's one thing to build a prototype, but it's another to actually earn recurring revenue.We discuss how to really sell to the Pentagon, LA's role as a hub for the new defense tech wave, and Hurd's own Chaos Industries and their modular counter-drone systems.00:00 — Meet Will Hurd from CIA to Congress to Chaos06:00 — How Hurd would solve partisan redistricting13:24 — The defense-tech moment24:20 — Air superiority isn’t dead36:32— How to sell to DoD

Is the AI bubble popping—or just catching its breath? Eric Newcomer and Tom Dotan spar over Nvidia jitters, Sam Altman’s “bubble” dinner, the MIT “95% fail” headline, app-vs-model margins (Cursor, Claude Code), and Chamath’s SPAC-as-casino shtick. Then Eric sits down with Vercel founder/CEO Guillermo Rauch for a fast, idea-dense jam: assistants → agents → multi-agent teams, why GPT-5’s real story is coding, “vibe coding” and code-last workflows, who gets paid in the era of AI factory-builders, whether to study CS, why taste beats code, and Guillermo’s six-month prediction for a breakout vertical agent.00:00 Did the AI “bubble” pop? Altman dinner & sell-off vibes01:16 MIT survey “95%” headline vs reality09:04 Capitalism, incentives & Chamath’s SPAC “casino”18:17 Interview starts — Guillermo Rauch (Vercel)22:07 GPT-5 reality check & the “Einstein-in-a-box” test37:37 Future of engineering + should you study CS?48:36 6-month prediction: a breakout vertical agent; underestimating GPT-50

For this episode, we brought on Ed Zitron to make the bear case against large language models and walk us through his “Hater’s Guide To The AI Bubble.” In this fiery debate with Eric Newcomer, Tom Dotan, and Madeline Renbarger, we dig into whether generative AI is the next platform shift or a $500B mirage. From the viral TaskRabbit CAPTCHA myth to SoftBank’s high-stakes bets, we debate the hype, shaky economics, and media spin driving the AI boom.

GPT-5 has landed! Is it the leap forward OpenAI promised or just an incremental upgrade? Eric Newcomer and Tom Dotan discuss this, how AI capex might be propping up the entire economy, and what Apple’s golden gifts to Trump say about Big Tech’s political bets.

This week on the Newcomer Podcast, we're joined by a very special guest: Danny Rimer, seasoned investor and longtime partner at Index Ventures, for a timely conversation around Figma’s highly anticipated IPO.Danny takes us behind the scenes of Index’s early bet on Figma and its visionary CEO Dylan Field, sharing how the deal came together and what made the design platform stand out in a crowded startup landscape. From there, we zoom out to talk about the current venture capital climate — what’s changed, what’s stayed the same, and what the smartest investors are watching right now.We also dig into AI’s evolving role in the startup ecosystem, the tension between hype and real value, and where Danny sees the next big opportunities emerging. Whether you're a founder, investor, or just love a good origin story, this is an episode you won’t want to miss.Timecodes:00:00 Introduction to Danny Rimer02:29 How Rimer met Figma and the beginnings of design as a category16:42 Figma's failed Adobe deal and comeback25:39 How Index approaches AI deals 31:00 AI's iPhone moment and looking beyond the chatbot39:10 Shifts in the venture capital industry

Tech leaders unveiled the American AI Action Plan on Wednesday and President Trump signed 3 executive orders with big handouts to AI companies. Madeline returns fresh off of a trip to Washington DC and gives Tom and Eric the lowdown on tech's victory lap at the nation's capital. Plus, even the altruists at Anthropic feel the need to raise Middle East money.Timecodes:01:45 - The All-In podcast might as well be state-run media05:16 - The vibes at the All-In Hill and Valley event08:50 - The coming AI abundance12:29 - Woke AI and the ministry of truth15:30 - America's strategic advantage is President Trump22:36 - The AI copyright kerfuffle32:36 - Dario faces the harsh reality of capitalism

Fresh back from London! In this episode, Eric Newcomer reunites with co-hosts James Wilsterman and Max Child of Volley to dive into the best moments from the Cerebral Valley AI Summit.From buzzy startup founders to incumbent innovators, the London event showcased a rapidly evolving AI landscape. But what stood out most? Eric, James, and Max break down their favorite clips and debate the key questions driving the industry right now:Models vs. Applications: Are we back in a “models win” moment?The Uber Dilemma: Why did Uber spin off its self-driving technology instead of competing with Waymo? Dara Khosrowshahi’s reasoning sparks a heated debate about platform dynamics, marketplace power, and whether Uber made the right call.Figma’s IPO Moment: With their S-1 filing just days after the summit, Dylan Field defended Figma’s AI strategy and new product launches.The Science of Discovery: Can AI models trained on “boring rule followers” actually make Nobel Prize-worthy breakthroughs?The End of Reading?: Synthesia’s CEO made the boldest prediction yet — that kids won’t read anymore, and video will replace text entirely. The hosts wrestle with what this means for human intelligence and whether writing really is thinking.The next Cerebral Valley AI Summit returns to San Francisco on November 12th!Timestamps08:21 Uber’s Self-Driving Strategy and Market Positioning16:56 Figma’s IPO Bear and Bull case26:17 Harry Stebbings’ Interview Insights with Granola’s CEO32:11 Exploring AI’s Role in Scientific Discovery38:26 The Impact of AI on Reading and Writing

The Newcomer Podcast returns just in time to have Eric, Tom, and Madeline weigh in on Meta's audacious AI hiring spree. The tech giant has enticed researchers from OpenAI, Google DeepMind, and Anthropic with huge paydays in the hopes it can bring its Llama models up to par with the competition. Next up, Ramp's report that companies have stopped purchasing AI tools made a lot of buzz this week, but it's still too early to call an AI peak.Later on in the episode, Grok's offensive replies aren't enough to slow down xAI's latest model launch. We close out the episode rehashing Sequoia partner Shaun Maguire's latest inflammatory tweets over New York mayoral candidate Zohran Mamdani.00:35 — Meta poaches top researchers to ail its flailing models11:13 — XAI outperforms despite Grok's offensive replies18:27 — It's too early to call the AI bubble28:50 — Shaun Maguire's tweets bring attention to Sequoia

Today on the pod, we're bringing you two of the liveliest panels from the 2025 Cerebral Valley AI Summit, held this week in London.Both panels — “The Autonomous Vehicle Rollout” and “Investing in 2030” — explore one of the major themes from the event: where AI is poised to show up next in our everyday lives, beyond the chatbot. Think voice, devices, and even your car.First up, we'll hear from Uber CEO, Dara Khosrowshahi, and Alex Kendall, Co-founder and CEO of Wayve, who are teaming up to bring self-driving cars to the UK.Then we turn to the investor perspective, with top European VCs — Philippe Botteri of Accel, Tom Hulme of Google Ventures, and Jan Hammer of Index Ventures — on where they see the biggest AI opportunities for founders in the years ahead.

We’re officially one week out from the Cerebral Valley AI Summit! On today’s episode, co-hosts James Wilsterman and Max Child of Volley join host Eric Newcomer to preview what’s ahead — from standout speakers to can’t-miss panels and the big ideas that will shape the conversations next week.To kick things off, Eric poses a timely question: What themes are starting to take shape across the participants and topics at this year’s summit? What’s really driving the energy in AI right now?Here are a few of the themes that emerged from the discussion:Designers are moving closer to engineering, not just prototyping but launching internal tools and shaping product development in deeper ways.The war for context is just beginning — expect fierce competition over who owns the layers that make AI actually useful.Vibe coding: is it a real paradigm shift, or just a fun phase? And how big could it get?Is there a Microsoft Office Suite for the AI era?Distribution vs. product: what do the strategies of Uber and Waymo reveal about the future of AI deployment? Who wins self-driving cars?Text box solution vs. product: should everyone be copying ChatGPT, or is that a mistake?The growing appetite for data is fueling a new surveillance state.And finally, Eric's "Sprinting Toward the End of History" — companies face competition from every direction, but is there an end point? It’s all building toward what promises to be a packed, thought-provoking week in Cerebral Valley. Let’s dive in!Timestamps:1:40: Eric poses the question1:55: Evolution of the role of the designer8:00: Text box vs product14:15: Unbundling ChatGPT19:19: Is there a Microsoft Office Suite for the AI era?22:10: Who owns the context26:02: Surveillance state36:57: Distribution vs product42:00: Sprinting until the end of history

In this second installment of the Cerebral Valley podcast series, co-hosts James Wilsterman and Max Child of Volley join Eric Newcomer for a thought-provoking conversation about the future of AI-generated voice and video — and what it means for our sense of reality.From TikTok trends to the future of Hollywood and podcasting, the trio explores where generative video might take us over the next five years. Will AI content dominate our feeds? Will we even be able to tell the difference?To put these predictions to the test, the hosts play The AI Video Turing Test — a game where they watch viral AI-generated videos from 2018 to today, ending with the latest clips made with Veo 3. Can they spot what’s real and what’s fake? And what makes some fakes feel too real?This episode dives deep into the shifting boundaries between synthetic and human-made content — and makes one thing clear: we’re no longer at the bottom of the uncanny valley. AI is climbing fast.The 2025 Cerebral Valley AI Summit will be held in London on June 25thTimestamps:02:50 — Predictions: AI in 5 years15:00 — Hollywood perceptions of AI18:55 — AI generated video games23:05 — AI Video Turing Test

The Cerebral Valley AI Summit is right around the corner! To help you navigate the fast-evolving AI landscape ahead of the event, Newcomer Podcast is launching a special four-part series — co-hosted by James Wilsterman and Max Child of Volley. Get insider insights, expert analysis, and fresh perspectives on the trends shaping the future of artificial intelligence.In this first episode, James, Max, and host Eric Newcomer dive into what it really means to be an AI agent — and explore how agentic AI could reshape the future of work and everyday life. From picking wedding outfits to writing code, they share personal experiences of agents in action and reflect on where this technology is headed next.So — where is AI headed? In the second half of the episode, the trio revisits market predictions made by AI last November and puts them to the test using fresh data pulled by Deep Research. After a spirited round of forecasting, they return to their 2024 AI Fantasy Drafts to see whose lineup is raising, exiting, and, ultimately, leading in the race for AI dominance.Our next episode focuses on AI's impact in voice and video, and may include a few more surprise games... The 2025 Cerebral Valley AI Summit will be held in London on June 25thTimestamps:00:39 - Intro & the scaling wall reversal06:13 — How we use Claude and Deep Research08:45 — Agents are here for the web search14:44 — Coding agents as the breakout tool24:24 — Update on last year's AI predictions36:51 — AI Fantasy Draft

We're welcoming Bloomberg's Kate Clark to the show this week and diving into her reporting on the rough fundraising environment for any VC that isn't an a16z or GC-style megafund. The only emerging funds that can raise, it seems, are ones that are started by investors who leave these brands. If it weren't for the AI funding bonanza, the situation would look even worse.We each make our predictions for how rosy or dreary the venture market will be 2 years from now. And, of course, take a moment to comment on Elon's DOGE departure.Timestamps:00:00 Intro and welcome to Kate Clark00:57 Emerging managers struggle to raise14:34 The X factor, sovereign wealth22:07 Venture market predictions32:51 Elon Musk out in Washington

In this special episode, we feature two interviews recorded live during Newcomer’s Breaking the Bank Summit, a financial technology summit held this week in San Francisco.We’re including two of the most dynamic discussions here, beginning with Gabriel Stengel of Rogo and Jeff Seibert of Digits, followed by an interview with Josh Reeves, CEO of Gusto.The episode kicks off with a breakdown of the event, highlighting the key debates that emerged between Rogo and Digits around the trustworthiness of LLMs in fintech, as well as Reeves’ perspective on the service intensive business and going shoeless in the office. After getting our hosts’ reactions, we dive in to live-recorded audio from the event.For a full selection of discussions from the summit, including video of each talk, visit the Newcomer Youtube at youtube.com/@newcomerpodTimecodes00:00 - Intro09:43 - Rogo + Digits Discussion28:13 - Josh Reeves, Gusto Interview

Eric relays his dispatch from Dimension Capital’s biotech summit in Park City, where the crowd was much more academic than the conferences we usually attend. Biotech stocks aren’t doing great, meanwhile university funding cuts could spell trouble for drug research. Still, people were rosy about AI tools. We also took a temperature check on the state of fintech, which investors tell us is mixed. Everyone’s hopeful about IPOs and streamlined stablecoins, but the dollar getting destabilized by the tariffs has some investors skittish. Later in the episode, Madeline explains how Trump’s crackdown on immigration is spooking startup founders and employees. Timestamps: 00:42 Lineup of our upcoming fintech summit02:02 Eric's dispatch from Dimension Capital and Recursion's biotech summit09:22 Fintech IPOs and stablecoins en vogue18:50 Heightened immigration enforcement spooks startup employees

How does the AI gold rush look from the helm of a $40-billion software giant? Salesforce co-founder, chair, and CEO Marc Benioff joins Eric Newcomer and Tom Dotan for a tour of the next tech boom cycle. The conversation opens with Benioff’s sweeping vision of “Agent Force 2.0,” where large language models paired with reasoning engines mint whole new classes of digital labor, and brands from Gucci to Disney are already swapping call-center scripts for autonomous agents.The episode closes on politics and philanthropy: Prop C, homelessness, the 2024 electoral tightrope, and how Benioff plans to work with any administration and still sleep at night.

This week, we kick off by discussing Ben Smith’s bombshell post ”The group chats that changed America,” that exposed the private chats that nudged Silicon Valley’s money crowd into Trump’s orbit. Then we hop to DC’s Hill-and-Valley Forum, where the mantra was industrial renaissance or bust. The race with China, AI’s essential energy demands, and the need to reshore American manufacturing were the talk of the forum. Fear of China loomed over the entire forum and only whispers of tariffs crossed the lips of attendees and speakers alike. In the back half, Eric and Madeline are joined by Lux Capital’s Josh Wolfe, fresh off his on-stage appearance at the Hill and Valley Forum. Wolfe predicts two flashpoints the commentariat is ignoring: a terror-fertile Sahel and a China-courting Latin America. He spars with Eric Newcomer and Madeline Renbargner over Trump’s tariffs, friend-shoring versus reshoring, and whether founder-led startups like Anduril can out-maneuver bloated primes. If you think that the only great power game is Taiwan, Wolfe widens the aperture to central Africa and the Americas. Timecodes00:00 - Intro01:10 - Silicon Valley’s Most Important Group Chats 08:18 - Hill and Valley’s “America First” Victory Lap 16:20 - Josh Wolfe on America’s Next War

We’re back to opining on the state of tech media! A16z has aqui-hired Erik Torenberg and his newsletter Turpentine, while the Technology Brothers with ties to Founders Fund have created a podcasting empire. Eric and Tom reminisce about the original wave of “going direct,” why it failed, and what’s different this time around. Later on, Madeline shares that crypto VCs are growing frustrated with President Trump’s meme coin grifts, and how hosting a private dinner for top coin holders doesn’t help legitimize the industry.