The Next Experiment

In this episode, we delve into Markus’ experiences with doing multidimensional biological experiments manually—from the exhilarating progress he made, to the definitive results he produced. Plus, we touch on how automation can scale multidimensional experimentation, and when is the right time to bring it into the mix. Conversation highlights 00:00 - Introduction01:24 - Markus’ early manual, multidimensional experiments, and their definitive results06:07 - The overwhelming number of combinations you explore in biology vs chemistry11:39 - What happens when you don’t use multidimensional methods20:37 - When you should automate multidimensional experiments23:02 - The exciting, uncharted territory that automation brings

It’s easy to say that the tried-and-tested way of doing biology isn’t helping us progress. It’s quite another to embrace new approaches.  That’s what we’re covering in this second episode. We talk about communicating the power of multidimensional experimentation for biology, the insights they unlock—and how often, it takes some time to entertain new-and-improved ways of working. Conversation highlights 00:00 Introduction 01:36 Phil’s tale of Dr Stevie vs Dr Charlie, or traditional vs multidimensional methods 10:40 Multidimensional? Design of Experiments? DOE? It’s all one in the same  12:19 How Markus got to a 7-fold increase in 3 weeks using multidimensional methods 15:55 The magic of multidimensional experiments lies in the statistics 16:49 Markus’ envelope-pushing multidimensional experiment with 27 factors 20:00 Markus admits that at first, he dismissed multidimensional experiments

In our first episode of The Next Experiment, we start by unpacking that all-important question:  Why is biology so hard?  In order to answer it, we get into the fundamentals. The nature of nature.  We talk about how biology’s interconnectedness makes experimentation in biology so uncertain; why the standard method of varying one parameter at a time isn’t cutting it; and how switching to a multidimensional approach is more important for biology than any other scientific discipline. Conversation highlights 00:00 Introduction 00:45 Why biology is different from other scientific disciplines 03:40 What emergence means, and how it relates to biological systems 06:03 Chemistry is a “solved problem”, and biological systems are “black boxes” 12:18 How multidimensional methods helped Markus make definitive progress 16:50 The counter-intuitive science lessons Phil remembers from primary school

We’re Markus and Phil, a biologist and statistician. We decided to come together and discuss the best experiments to cut through biological complexity. If you have this sense that there might be a better way of making progress in biology, subscribe and join us. Stay tuned for our very first episode, launching on November 6th.