Claim OwnershipThe Stem Cell Podcast
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Join Drs. Daylon James and Arun Sharma as they discuss the latest stem cell research, and interview some of the brightest minds in the field.
275 Episodes
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Dr. Bas Trietsch is the Chief Technology Officer and Co-Founder at Mimetas, a company working to contribute to groundbreaking therapies with their screenable, physiologically relevant 3D human disease models. He talks about tissue-relevant models for drug discovery, and how organ-on-a-chip technology can help address scalability and reproducibility.
Dr. Thorold Theunissen is an Assistant Professor of Developmental Biology at Washington University in St. Louis investigating the molecular basis of pluripotency, the mechanisms of trophoblast development, and the generation of stem cell-based embryo models.
Dr. Nicolas Rivron is a Principal Investigator at the Institute of Molecular Biotechnology of the Austrian Academy of Sciences in Vienna. His group recreates embryonic development using mammalian stem cells in a dish to better understand the encoded principles of self-organization. He talks about building human blastoid models and using them to study implantation. He also discusses differences in development between mice and humans, trophectoderm stem cells, and an ethical framework for embryo models.
Dr. Laura Andres-Martin is a Research Investigator, Oncology, Dr. Daniel Paul is the Senior VP, Discovery & Platform Development, and Dr. Raeka Aiyar is the VP, Scientific & DEIB Outreach at the New York Stem Cell Foundation (NYSCF). This episode was recorded live and in-person at the NYSCF Research Institute. The panelists talk about NYSCF's approach to automation, their women's reproductive cancer initiative, and promoting inclusion and belonging in science. They also talk about Founder Susan Solomon's legacy and future plans to break down barriers in stem cell research.
1Dr. Nathaniel Huebsch is an Assistant Professor of Biomedical Engineering at Washington University in St. Louis. His lab focuses on understanding how mechanical cues originating at cell-cell and cell-extracellular matrix contacts influence signaling and fate. They are especially interested in how those cues affect heart development and disease. He talks about cardiac models and cardiomyocyte maturity.
Dr. Thomas Durcan is an Associate Professor and Director of the Early Drug Discovery Unit at the Montreal Neurological Institute. He oversees a team of 40+ research staff and students, committed to applying patient-derived stem cells towards the development of phenotypic discovery assays and 3D neuronal organoid models for neurodegenerative and neurodevelopmental disorders. He talks about modeling sporadic ALS in a dish, partnering with the Michael J. Fox Foundation, and promoting open science.
In June 2023, we attended ISSCR 2023, the annual meeting of the International Society for Stem Cell Research, in Boston. We spoke with delegates about their research and impressions of the meeting, including their reasons for attending, what they were most looking forward to, and the most memorable research presented.
Dr. Thomas Zwaka is the Director of the Huffington Center for Cell-Based Research in Parkinson's Disease and a Professor of Regenerative and Developmental Biology at the Icahn School of Medicine at Mount Sinai. His research focuses on fundamental questions surrounding stem cell biology, including how to reverse the process of differentiation and “re-program” any given cell type into a pluripotent stem cell.
In June 2023, Daylon and Arun attended the International for Stem Cell Research's (ISSCR) annual meeting in Boston, Massachusetts, and recorded daily episodes discussing highlights of the final day of the meeting.
In June 2023, Daylon and Arun attended the International Society for Stem Cell Research's (ISSCR) annual meeting in Boston, Massachusetts, and recorded daily episodes discussing highlights of the third day of the meeting.
In June 2023, Daylon and Arun attended the International Society for Stem Cell Research’s (ISSCR) annual meeting in Boston, Massachusetts, and recorded daily episodes discussing highlights of the second day of the meeting.
In June 2023, Daylon and Arun attended the International Society for Stem Cell Research's (ISSCR) annual meeting in Boston, Massachusetts, and recorded daily episodes discussing highlights of the first day of the meeting. They discuss the pre-meeting workshops, including Arun's own talk on stem cell research in space, as well as highlights from the morning's focus sessions and innovation showcases. They also dive into the Presidential Symposium and the new technologies presented in Plenary II.
Dr. Emma Rawlins is a Senior Group Leader at the Gurdon Institute in the Department of Physiology, Development, and Neuroscience at the University of Cambridge. She talks about modeling fetal lung development using organoids, using single-cell RNA sequencing to create a human lung fetal atlas, and her advice to trainees to follow their hearts.
Dr. Insoo Hyun is the Director of the Center for Life Sciences and Public Learning at the Museum of Science in Boston, and a Member of the Harvard Medical School Center for Bioethics. He talks about embryo models for early development, his work on the ISSCR's guidelines for stem cell research, and advances in reproductive medicine.
Dr. Aileen Anderson is the Director of the Sue and Bill Gross Stem Cell Research Center at the University of California, Irvine. Her lab investigates the role of inflammatory mechanisms in degeneration and regeneration in the injured central nervous system. She talks about cell therapy for spinal cord injury and how academic labs can collaborate with companies to move toward the clinic. She also discusses biomaterials to support axon regeneration.
Dr. Shannon McKinney-Freeman is a Principal Investigator and Member at St. Jude Children's Research Hospital. Her lab focuses on the fundamental biology of hematopoietic stem cells (HSCs). She talks about the role of HSCs in sickle cell disease and the state of HSC transplantation research. She also discusses her work on hematopoietic progenitor expansion.
Dr. Sergiu Pașca is the Kenneth T. Norris, Jr. Professor of Psychiatry and Behavioral Sciences at Stanford University and the Bonnie Uytengsu and Family Director of the Stanford Brain Organogenesis Program. His lab has pioneered and applied neural organoid and assembloid technologies to make discoveries in fundamental and clinical neuroscience. He talks about the response to his viral TED Talk and the importance of names for nervous system models. He also discusses CRISPR screening in assembloids to study autism, transplanting cortical organoids into rats, and biocompatible polymers for neural organoids.
Dr. Stylianos Lefkopoulos is an Associate Editor of Nature Cell Biology. He talks about a day in the life of an editor and what he looks for in a manuscript. He also discusses the role of preprints in publishing and promoting diversity in STEM.
Dr. Noriaki Ono is an Associate Professor at the University of Texas Health Center at Houston. His research focuses on bone development and regeneration. He talks about in vivo lineage tracing techniques and how early perichondrial cells contribute to developing bones. He also discusses the art and science of dentistry, mentorship, and moving his lab across the country.
Dr. Ryan Conder is the Director of Epithelial and Organoid Systems at STEMCELL Technologies. He talks about the next phase in organoid research and what questions organoids can help answer. He also discusses his experience doing a postdoc in Vienna, and Vancouver as a growing biotech hub.
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