Ep. 274: “Brain Organoids” Featuring Dr. Ziyuan Guo
Description
Guest:
Dr. Ziyuan Guo is an Assistant Professor of Pediatrics at the Center for Stem Cell & Organoid Medicine at Cincinnati Children’s Hospital. He talks about in vivo reprogramming and cell and gene therapy in neurodevelopmental and neurodegenerative disorders. He also discusses assembloids to model the blood-brain barrier and strategies for organoid vascularization.
Featured Products and Resources:
- Use STEMdiff Cerebral Organoid Kits to mimic early brain development.
- Get a free wallchart showing how neural organoids are generated and can be used to better understand brain development.
The Stem Cell Science Round Up
Modeling Celiac Disease – Scientists generated air–liquid interface duodenal organoids from celiac disease patients.
Intestinal Immuno-Organoids – Intestinal immuno-organoids can be used to study tissue-resident immune responses in tumorigenesis and other diseases.
Naive PSCs in the Blastocyst – A blastocyst motif substrate reverts mouse and human PSCs to a naive state in vitro.
Sensory Neuron Excitability – Schwann cell-secreted PGE2 promotes neuronal maturation and normal sensory function.
Image courtesy of Dr. Ziyuan Guo
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