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Why do antihistamines cause weight gain? And how does hormonal birth control affect metabolism?In this episode, Lara looks at:how common medications affect metabolismwhy birth control that is *androgenic* is more likely to cause weight gain, andwhether natural progesterone is more likely to cause weight gain or weight loss.Links:The histaminergic system as a target for the prevention of obesity and metabolic syndromeHigh H1-affinity antidepressants and risk of metabolic syndrome in bipolar disorderNatural treatment of menstrual migrainesWeight change among women using intramuscular depot medroxyprogesterone acetate, a copper intrauterine device, or a levonorgestrel implant for contraceptionImpact of micronized progesterone on body weight, body mass index, and glucose metabolism: a systematic reviewCyclic progesterone therapy for PCOS
Are you a morning person or an evening person? And could that affect your ability to lose weight?In this episode, Lara looks at chronotype, which is your individual disposition to be awake or asleep at certain times. And how that might affect your overall health and metabolism.
The supplement inositol is a superstar for treating polycystic ovary syndrome. It’s also been clinically trialled for weight loss, thyroid disease, anxiety, insomnia, and premenstrual mood symptoms. In this episode, Lara looks at:"what is inositol?" and how to get it from dietmyo-inositol versus D-chiro-inositol, and why it's all a little confusing.One thing Lara forgot to mention is that to get results with inositol, you need to commit to it for at least three months. And if it works, you’ll probably want to stay on it for years. Luckily, inositol can be quite inexpensive, especially if you choose straight myo-inositol powder.Links:Myo-inositol for insulin resistance, metabolic syndrome, polycystic ovary syndrome and gestational diabetesInositol treatment for PCOS should be science-based and not arbitraryCyclic progesterone therapy for PCOS
What do post-pill acne, hair loss, and weight gain all have in common? They can all be the result of a temporary surge in androgens when trying to come off certain types of hormonal birth control.In this episode, Lara discusses post-pill androgen symptoms including:why pills like Yasmin are the hardest to come offhow androgens can cause weight gain, andnatural treatments such as zinc, berberine, and cyclic progesterone therapy.Links:Ovulation is the main event of the menstrual cycleThe central role of ovulatory disturbances in the etiology of androgenic polycystic ovary syndrome (PCOS)—Evidence for treatment with cyclic progesteroneBeyond the label: A patient-centred approach to polycystic ovary syndromeCyclic progesterone therapy for PCOS
Are premenstrual mood symptoms caused by progesterone or helped by progesterone? And why do antihistamines give such relief?In this episode, Lara discusses premenstrual mood symptoms including:the role of histamine and mast cell activationprogesterone sensitivity, andeffective natural treatments such as magnesium, iodine, and body-identical progesterone.Links:Lara Briden's mailing listMagnesium in the gynecological practice: a literature review8 Ways magnesium rescues hormones Taurine: 5 benefits for women's health
There can be a strong hormonal component to abdominal weight gain. And in most people, that hormone is insulin. In this episode, Lara discusses insulin resistance including:why you could have insulin resistance even if your blood sugar is normalthe role of mitochondria, andall the ways to lower insulin and improve metabolism.Links:Online workshop: Metabolic health and vitality for women over 40Insulin resistance is a cellular antioxidant defense mechanismHigh-dose fructose can cause or worsen insulin resistance (but fruit is okay)
If you're going to take hormone therapy, it's safer to take hormones that are identical to human hormones. In other words, hormones that are body-identical or bioidentical. The concept of bioidentical used to be controversial but is now conventional and mainstream.In this episode, Lara discusses hormone therapy including:why the concept of bioidentical was controversial when it didn't need to beoral micronized progesterone for heavy periods, mood, sleep, and perimenopausal migraines, andsome facts about body-identical estrogen (four uncontroversial things and one controversial).Links:The crucial difference between progesterone and progestinsCyclic progesterone therapy for PCOSThe central role of ovulatory disturbances in the etiology of androgenic polycystic ovary syndrome (PCOS)—Evidence for treatment with cyclic progesteroneBlog post with a list of body-identical brand namesOnline workshop: Metabolic health and vitality for women over 40
Endometriosis is an inflammatory disease that’s affected by hormones but is not caused by hormones. Instead, endometriosis is, at least in part, a disease of immune dysfunction. In this episode, Lara discusses some of the new endometriosis research including:the link with genes that increase the risk of autoimmune diseasethe role of a bacterial toxin called lipopolysaccharide or LPS, andnew targets for natural immune-modulating treatment.Links to:Blog post: Immune treatment for endometriosis Blog post: Why I prescribe iodine for breast pain, ovarian cysts, and PMDD
Were you told you have polycystic ovary syndrome or PCOS based on a pelvic ultrasound? That may or may not be an accurate diagnosis because PCOS cannot actually be diagnosed or ruled out with ultrasound.In this episode, Lara discusses PCOS including:why PCOS is an umbrella termthe difference between polycystic ovaries and ovarian cysts, andwhy some women with undereating and endometriosis are being mistakenly told they have PCOS.Links to:Blog post: PCOS cannot be diagnosed (or ruled out) by ultrasoundBlog post about the 4 types of PCOS.Citation for the quote about polycystic ovaries: Diagnosis of Polycystic Ovary Syndrome: Which Criteria to Use and When?Lara's forum where you can post a comment or suggest a topic for a future episode. 
In a normal period, you should not lose more than about 80 mL of menstrual fluid over all the days of the bleed. That’s equivalent to about five tablespoons spread over all the days of the bleed. In this episode, Lara discusses heavy periods including:the role of hormone imbalance, mast cell activation, and insulin resistance,simple period-lightening strategies such as iron, zinc, and a dairy-free diet, andusing body-identical progesterone to lighten periods. Links to:Blog post about heavy periods.Blog post about testing for insulin resistance.Blog post with a list of brand names of body-identical progesterone. Professor Prior's document: Managing menorrhagia without surgery. Lara's forum where you can post a comment or suggest a topic for a future episode. 
The pill is commonly prescribed to "regulate periods," but it can't actually do that because withdrawal bleeds from contraceptive drugs are not real menstrual cycles. In episode one of The Lara Briden Podcast, Dr Lara covers:what is a real menstrual cyclewhy there's no medical reason to bleed monthly on the pill, and the difference between contraceptive drugs and real hormones. Links to:Blog post about cyclic progesterone therapy for PCOS.Lara's forum where you can post a comment or suggest a topic for a future episode. 
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