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Peter Attia, MD is a highly respected expert in preventive medicine, focused on the crucial subject of longevity and cardiovascular health. He's also the author of the NY Times best selling book Outlive - which I highly recommend if you have not read it already. Peter's philosophy transcends the conventional goal of merely extending lifespan; it's about enriching the quality of every year, ensuring that each stage of life is lived with optimal health and vitality.

In this episode, we discuss:

• (00:00 ) Introduction
• (07:36 ) Defining cardiovascular disease
• (09:43 ) Coronary plaque and fatality risk
• (13:34 ) How ApoB predicts heart disease
• (21:34 ) Factors elevating ApoB
• (27:23 ) Does high ApoB cause cardiovascular disease
• (37:01 ) ApoB thresholds for ASCVD prevention
• (40:27 ) Dietary factors raising ApoB
• (49:33 ) Genetics of ApoB and LDL
• (53:24 ) Does low LDL increase cancer?
• (56:19 ) Cholesterol-lowering drugs
• (59:59 ) Statins, uses, and side effects
• (1:03:12 ) Are statins toxic to mitochondria?
• (1:09:56 ) Ubiquinol for statin-induced muscle soreness
• (1:11:09 ) How to train in zone 2
• (1:17:09 ) Statins and neurodegenerative disease risk
• (1:21:54 ) Cholesterol synthesis in the brain (desmosterol role)
• (1:25:58 ) Statin alternatives
• (1:36:49 ) Berberine for CVD Risk Reduction?
• (1:39:36 ) Muscle as a glucose sink
• (1:51:38 ) Hemoglobin A1C Levels and Mortality Data
• (1:55:35 ) 80/20 Zone 2/VO2 Max Training Protocol
• (2:02:12 ) Insights from VO2 max testing data
• (2:12:17 ) How obesity increases cancer risk
• (2:15:03 ) Cancer screening
• (2:40:32 ) Menopause – hormonal shifts and health effects
• (2:45:13 ) Hormone replacement therapy (HRT)
• (2:58:57 ) Perimenopause diagnosis with hormone levels
• (3:02:04 ) HRT's impact on dementia, cancer, and heart disease risk
• (3:07:42 ) Vitamin D
• (3:16:24 ) Testosterone replacement for women's sexual function
• (3:18:47 ) HRT safety 10 years post-menopause
• (3:23:05 ) Testosterone & TRT
• (3:32:33 ) Blood pressure
• (3:45:30 ) Peter's longevity optimization routines

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