This podcast episode offers an extensive overview of Atul Butte's pioneering contributions to translational bioinformatics and data-driven medicine. They highlight his early work leveraging big data for biological discovery, including coining "translational bioinformatics." Much of the text focuses on his breakthroughs in AI-driven drug repositioning, demonstrating how computational methods could uncover new uses for existing drugs and validating these findings experimentally. Furthermore, the sources chronicle his entrepreneurial ventures, detailing the founding of companies like Personalis, NuMedii, and Carmenta Bioscience, which aimed to translate academic research into practical healthcare applications. Finally, the text explores Butte's core philosophies, emphasizing his advocacy for open data, the scalability of computational science, academic-industry synergy, and a patient-centered approach in biomedical research, positioning him as a pivotal figure in the evolution of AI in drug discovery. Produced by Dr. Jake Chen.